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Neuroregenerative Effect of Oxandrolone: A Case Report.

Bianchi V, Marbini A - Am J Case Rep (2015)

Bottom Line: The brain and spinal cord neurons have gonadal steroid receptors and various studies have shown at structural and molecular levels that androgenic steroids have a significant trophic effect on the brain and spinal cord.Muscle biopsy revealed a significant increase of type grouping of muscle fibers, an expression of regeneration and reinnervation processes.Data ensuing from this single case-report suggest that anabolic androgenic steroids have a potential neuroregenerative effect, with an inherent improvement in neuromuscular efficiency through an increased myelin synthesis at peripheral nervous system site.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Physiology of Exercise and Human Performance, Stella Maris Clinical Center, Falciano, San Marino.

ABSTRACT

Background: Anabolic steroids have the clinical effect of increasing protein synthesis in muscle and other tissues. The brain and spinal cord neurons have gonadal steroid receptors and various studies have shown at structural and molecular levels that androgenic steroids have a significant trophic effect on the brain and spinal cord.

Case report: We evaluated the effect of Oxandrolone (an FDA-approved anabolic steroid) at the dose of 20 mg/day for 3 months added to concomitant exercise strength training 3 times a week in a patient affected by a demyelinating disease, Charcot-Marie-Toot 1 (CMT1). After the treatment, an increase in muscular strength and walking capacity was observed. Muscle biopsy revealed a significant increase of type grouping of muscle fibers, an expression of regeneration and reinnervation processes.

Conclusions: Data ensuing from this single case-report suggest that anabolic androgenic steroids have a potential neuroregenerative effect, with an inherent improvement in neuromuscular efficiency through an increased myelin synthesis at peripheral nervous system site.

No MeSH data available.


Related in: MedlinePlus

Same muscle biopsy. The type grouping is more evident, showing an increased clustering of muscle fibers of the same metabolic type (enlargement ×40).
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f3-amjcaserep-16-763: Same muscle biopsy. The type grouping is more evident, showing an increased clustering of muscle fibers of the same metabolic type (enlargement ×40).

Mentions: We obtained signed informed consent from the patient for nerve and muscle biopsies. Before treatment, the sural nerve biopsy showed peripheral neuropathy involving the myelinic axons (Figure 1). Onion bulbs in the nerves of patients with CMT1 are characteristic of the disease and are present in several presentations of CMT1 [11]. The name is due to their resemblance to the layers of an onion sliced in half. After the program, a muscle biopsy was obtained from the quadriceps femoris. The specimen was frozen in isopentane (BDH) and cooled to −160°C in liquid nitrogen. Serial 10-μm-thick frozen sections were prepared for histological and histochemical examination, as previously reported [12]. Stains used included hematoxylin-eosin (H&E), modified Gomori trichrome, myofibrillar adenosine triphosphatase (ATPase) at pH of 9.4, 4.6, and 4.35, NADH-tetrazolium reductase (NADH-Tr), succinic dehydrogenase (SDH), lactic dehydrogenase (LDH), cytochrome c oxidase (COX), Oil red O, myoadenylate deaminase (MAD), and periodic acid Schiff with and without diastase. NADH (in black) show aspects of type grouping: enlargement ×40 and ×100, reaction ATPase at pH 9.4×100 e ×40. It is evidence of an extensive type grouping. The fibres are hypotrophic and others are atrophic and angulate (Figures 2, 3). An extensive type-grouping consisting of cluster of type II fibres is suggestive of a reinnervation process. In histochemical stains, such motor units appear as groups of myofibers of the same histochemical type (fiber type grouping).


Neuroregenerative Effect of Oxandrolone: A Case Report.

Bianchi V, Marbini A - Am J Case Rep (2015)

Same muscle biopsy. The type grouping is more evident, showing an increased clustering of muscle fibers of the same metabolic type (enlargement ×40).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4629627&req=5

f3-amjcaserep-16-763: Same muscle biopsy. The type grouping is more evident, showing an increased clustering of muscle fibers of the same metabolic type (enlargement ×40).
Mentions: We obtained signed informed consent from the patient for nerve and muscle biopsies. Before treatment, the sural nerve biopsy showed peripheral neuropathy involving the myelinic axons (Figure 1). Onion bulbs in the nerves of patients with CMT1 are characteristic of the disease and are present in several presentations of CMT1 [11]. The name is due to their resemblance to the layers of an onion sliced in half. After the program, a muscle biopsy was obtained from the quadriceps femoris. The specimen was frozen in isopentane (BDH) and cooled to −160°C in liquid nitrogen. Serial 10-μm-thick frozen sections were prepared for histological and histochemical examination, as previously reported [12]. Stains used included hematoxylin-eosin (H&E), modified Gomori trichrome, myofibrillar adenosine triphosphatase (ATPase) at pH of 9.4, 4.6, and 4.35, NADH-tetrazolium reductase (NADH-Tr), succinic dehydrogenase (SDH), lactic dehydrogenase (LDH), cytochrome c oxidase (COX), Oil red O, myoadenylate deaminase (MAD), and periodic acid Schiff with and without diastase. NADH (in black) show aspects of type grouping: enlargement ×40 and ×100, reaction ATPase at pH 9.4×100 e ×40. It is evidence of an extensive type grouping. The fibres are hypotrophic and others are atrophic and angulate (Figures 2, 3). An extensive type-grouping consisting of cluster of type II fibres is suggestive of a reinnervation process. In histochemical stains, such motor units appear as groups of myofibers of the same histochemical type (fiber type grouping).

Bottom Line: The brain and spinal cord neurons have gonadal steroid receptors and various studies have shown at structural and molecular levels that androgenic steroids have a significant trophic effect on the brain and spinal cord.Muscle biopsy revealed a significant increase of type grouping of muscle fibers, an expression of regeneration and reinnervation processes.Data ensuing from this single case-report suggest that anabolic androgenic steroids have a potential neuroregenerative effect, with an inherent improvement in neuromuscular efficiency through an increased myelin synthesis at peripheral nervous system site.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Physiology of Exercise and Human Performance, Stella Maris Clinical Center, Falciano, San Marino.

ABSTRACT

Background: Anabolic steroids have the clinical effect of increasing protein synthesis in muscle and other tissues. The brain and spinal cord neurons have gonadal steroid receptors and various studies have shown at structural and molecular levels that androgenic steroids have a significant trophic effect on the brain and spinal cord.

Case report: We evaluated the effect of Oxandrolone (an FDA-approved anabolic steroid) at the dose of 20 mg/day for 3 months added to concomitant exercise strength training 3 times a week in a patient affected by a demyelinating disease, Charcot-Marie-Toot 1 (CMT1). After the treatment, an increase in muscular strength and walking capacity was observed. Muscle biopsy revealed a significant increase of type grouping of muscle fibers, an expression of regeneration and reinnervation processes.

Conclusions: Data ensuing from this single case-report suggest that anabolic androgenic steroids have a potential neuroregenerative effect, with an inherent improvement in neuromuscular efficiency through an increased myelin synthesis at peripheral nervous system site.

No MeSH data available.


Related in: MedlinePlus