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Radiation-induced organizing pneumonia after stereotactic body radiotherapy for lung tumor.

Ochiai S, Nomoto Y, Yamashita Y, Murashima S, Hasegawa D, Kurobe Y, Toyomasu Y, Kawamura T, Takada A, Ii N - J. Radiat. Res. (2015)

Bottom Line: A statistically significant association between G2/3 RP in the subacute phase and OP was shown ( P: = 0.040).In two of the five patients who developed OP, the symptoms and radiographic change were improved rapidly by corticosteroid administration.Three patients with minor symptoms were managed without corticosteroid administration and OP resolved without any relapse.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Matsusaka Central Hospital, 102 Kobou Kawai-machi, Matsusaka, Mie, 515-8566, Japan sochiai1981@gmail.com.

No MeSH data available.


Related in: MedlinePlus

Comparison of the cumulative incidence of organizing pneumonia (OP) of patients with or without Grade 2 or 3 radiation pneumonitis (G2/3 RP) within the subacute phase with landmark method. G2/3 RP 2 in subacute phase was shown to be a significant risk factor for development of OP, compared with those without G2/3 RP (Gray's test P = 0.040).
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RRV049F3: Comparison of the cumulative incidence of organizing pneumonia (OP) of patients with or without Grade 2 or 3 radiation pneumonitis (G2/3 RP) within the subacute phase with landmark method. G2/3 RP 2 in subacute phase was shown to be a significant risk factor for development of OP, compared with those without G2/3 RP (Gray's test P = 0.040).

Mentions: Of the 78 patients, 72 (92.3%) were followed up radiologically for at least 6 months or died within 6 months after SBRT. These patients were analyzed for OP as a late adverse event after SBRT. Among them, 7 patients (9.6%) developed Grade 2/3 OP after SBRT. Of these, Grade 3 RP occurred in 1 patient and the others had Grade 2 RP. G2/3 RP developed at 2–4 months (subacute phase) after SBRT, and the cumulative incidence of G2/3 RP was 9.7% (95% CI, 4.2–17.9) at 6 months. No statistically significant factor for developing G2/3 RP was found in Gray's test in this subgroup. G2/3 RP in the subacute phase was shown to be a statistically significant risk factor for development of OP, using a landmark method (P = 0.040) (Fig. 3). The 1-year and 2-year cumulative incidence was 14.3% and 28.6% in patients with prior G2/3 RP and 3.1% and 5.4% in patients without G2/3 RP, respectively (Fig. 3).Fig. 3.


Radiation-induced organizing pneumonia after stereotactic body radiotherapy for lung tumor.

Ochiai S, Nomoto Y, Yamashita Y, Murashima S, Hasegawa D, Kurobe Y, Toyomasu Y, Kawamura T, Takada A, Ii N - J. Radiat. Res. (2015)

Comparison of the cumulative incidence of organizing pneumonia (OP) of patients with or without Grade 2 or 3 radiation pneumonitis (G2/3 RP) within the subacute phase with landmark method. G2/3 RP 2 in subacute phase was shown to be a significant risk factor for development of OP, compared with those without G2/3 RP (Gray's test P = 0.040).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4628220&req=5

RRV049F3: Comparison of the cumulative incidence of organizing pneumonia (OP) of patients with or without Grade 2 or 3 radiation pneumonitis (G2/3 RP) within the subacute phase with landmark method. G2/3 RP 2 in subacute phase was shown to be a significant risk factor for development of OP, compared with those without G2/3 RP (Gray's test P = 0.040).
Mentions: Of the 78 patients, 72 (92.3%) were followed up radiologically for at least 6 months or died within 6 months after SBRT. These patients were analyzed for OP as a late adverse event after SBRT. Among them, 7 patients (9.6%) developed Grade 2/3 OP after SBRT. Of these, Grade 3 RP occurred in 1 patient and the others had Grade 2 RP. G2/3 RP developed at 2–4 months (subacute phase) after SBRT, and the cumulative incidence of G2/3 RP was 9.7% (95% CI, 4.2–17.9) at 6 months. No statistically significant factor for developing G2/3 RP was found in Gray's test in this subgroup. G2/3 RP in the subacute phase was shown to be a statistically significant risk factor for development of OP, using a landmark method (P = 0.040) (Fig. 3). The 1-year and 2-year cumulative incidence was 14.3% and 28.6% in patients with prior G2/3 RP and 3.1% and 5.4% in patients without G2/3 RP, respectively (Fig. 3).Fig. 3.

Bottom Line: A statistically significant association between G2/3 RP in the subacute phase and OP was shown ( P: = 0.040).In two of the five patients who developed OP, the symptoms and radiographic change were improved rapidly by corticosteroid administration.Three patients with minor symptoms were managed without corticosteroid administration and OP resolved without any relapse.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Matsusaka Central Hospital, 102 Kobou Kawai-machi, Matsusaka, Mie, 515-8566, Japan sochiai1981@gmail.com.

No MeSH data available.


Related in: MedlinePlus