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No Definite Association between Human Parvovirus B19 Infection and Behçet Disease.

Habibagahi M, Habibagahi Z, Saidmardani SM, Sadeghian F - Iran J Med Sci (2015)

Bottom Line: All findings were compared to the results from 42 healthy persons.No correlation was found between the presence of anti-B19 antibodies and the clinical observations.More studies on designed animal models and surveys on patients should be done to resolve this controversy.

View Article: PubMed Central - PubMed

Affiliation: Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

ABSTRACT

Background: The etiology of the Behçet disease (BD) has remained obscured. There have been studies to show the association of BD to infections like herpes simplex, hepatitis, and parvovirus B19 however, the findings are rather controversial.

Materials and methods: We selected 55 patients with the best matched symptoms of BD and measured the loads of B19 DNA in their plasma by quantitative real time PCR and verified their seropositivity by ELISA. All findings were compared to the results from 42 healthy persons.

Results: Patients showed a wide spectrum of BD symptoms. Serologic studies showed high prevalence of B19 IgG among the tested patients which was not statistically different with the healthy population (72.7% vs. 85.7%, respectively). Similarly, the prevalence of B19 IgM between patients and controls was not different (18% vs. 11.9%, respectively). No correlation was found between the presence of anti-B19 antibodies and the clinical observations. Only one person from the patient and control groups had detectable levels of B19 DNA without any difference or correlation with the disease symptoms.

Conclusion: Our data could not establish an association between B19 parvovirus infection and Behçet disease, although there have been reports of such correlation. Nevertheless, there might be indirect relation in genetically susceptible individuals after viral infections. More studies on designed animal models and surveys on patients should be done to resolve this controversy.

No MeSH data available.


Related in: MedlinePlus

Shows the distribution of B19 specific IgG and IgM concentration in the patient and control groups.
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Figure 1: Shows the distribution of B19 specific IgG and IgM concentration in the patient and control groups.

Mentions: Anti-B19 IgG antibody was found in 72.7% (N=40, 16 male and 24 female) of the patients and 85.7% (N=36, 13 male and 23 female) of the healthy individuals. The rate of IgG seroprevalence was not significantly different between the patients and the healthy participants (P>0.1). Ten patients (18%) and five healthy persons (11.9%) had detectable B19-specific IgM antibody in their plasma. Comparison of B19 IgM prevalence did not show significant difference between the patients and the healthy group (P=0.3). figure 1 demonstrates the distribution of IgG and IgM immunoglobulin concentrations of the patients and controls. Interestingly, in both studied groups, individuals with B19 IgM simultaneously had detectable amounts of IgG antibody in their plasma. Among the studied patients, no statistically significant correlation was found between B19 seroconversion and disease severity, disease onset history or other studied clinical findings (P>0.1). figure 2 shows the distribution of the seropositive and seronegative patients with different disease severity. There was no statistically significant difference in the frequency of patients with B19 antibodies among patients with different therapy regimens (P>0.3).


No Definite Association between Human Parvovirus B19 Infection and Behçet Disease.

Habibagahi M, Habibagahi Z, Saidmardani SM, Sadeghian F - Iran J Med Sci (2015)

Shows the distribution of B19 specific IgG and IgM concentration in the patient and control groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4628139&req=5

Figure 1: Shows the distribution of B19 specific IgG and IgM concentration in the patient and control groups.
Mentions: Anti-B19 IgG antibody was found in 72.7% (N=40, 16 male and 24 female) of the patients and 85.7% (N=36, 13 male and 23 female) of the healthy individuals. The rate of IgG seroprevalence was not significantly different between the patients and the healthy participants (P>0.1). Ten patients (18%) and five healthy persons (11.9%) had detectable B19-specific IgM antibody in their plasma. Comparison of B19 IgM prevalence did not show significant difference between the patients and the healthy group (P=0.3). figure 1 demonstrates the distribution of IgG and IgM immunoglobulin concentrations of the patients and controls. Interestingly, in both studied groups, individuals with B19 IgM simultaneously had detectable amounts of IgG antibody in their plasma. Among the studied patients, no statistically significant correlation was found between B19 seroconversion and disease severity, disease onset history or other studied clinical findings (P>0.1). figure 2 shows the distribution of the seropositive and seronegative patients with different disease severity. There was no statistically significant difference in the frequency of patients with B19 antibodies among patients with different therapy regimens (P>0.3).

Bottom Line: All findings were compared to the results from 42 healthy persons.No correlation was found between the presence of anti-B19 antibodies and the clinical observations.More studies on designed animal models and surveys on patients should be done to resolve this controversy.

View Article: PubMed Central - PubMed

Affiliation: Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

ABSTRACT

Background: The etiology of the Behçet disease (BD) has remained obscured. There have been studies to show the association of BD to infections like herpes simplex, hepatitis, and parvovirus B19 however, the findings are rather controversial.

Materials and methods: We selected 55 patients with the best matched symptoms of BD and measured the loads of B19 DNA in their plasma by quantitative real time PCR and verified their seropositivity by ELISA. All findings were compared to the results from 42 healthy persons.

Results: Patients showed a wide spectrum of BD symptoms. Serologic studies showed high prevalence of B19 IgG among the tested patients which was not statistically different with the healthy population (72.7% vs. 85.7%, respectively). Similarly, the prevalence of B19 IgM between patients and controls was not different (18% vs. 11.9%, respectively). No correlation was found between the presence of anti-B19 antibodies and the clinical observations. Only one person from the patient and control groups had detectable levels of B19 DNA without any difference or correlation with the disease symptoms.

Conclusion: Our data could not establish an association between B19 parvovirus infection and Behçet disease, although there have been reports of such correlation. Nevertheless, there might be indirect relation in genetically susceptible individuals after viral infections. More studies on designed animal models and surveys on patients should be done to resolve this controversy.

No MeSH data available.


Related in: MedlinePlus