Limits...
Comparing the Levels of Trace Elements in Patients With Diabetic Nephropathy and Healthy Individuals.

Makhlough A, Makhlough M, Shokrzadeh M, Mohammadian M, Sedighi O, Faghihan M - Nephrourol Mon (2015)

Bottom Line: Mean ± SD levels of Zn, Cu and Cr were significantly decreased in blood samples of patients compared to healthy subjects (P < 0.01).Meanwhile in these patients, low serum levels of Cu, Zn and Cr were not associated with factors such as drinking water.Possible causes should be sought in other factors like urine, intervention factors in absorption and utilization and individual conditions.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology, Diabetic Research Center of Mazandaran University of Medical Sciences, Sari, IR Iran.

ABSTRACT

Background: Diabetic nephropathy is the most common cause of end stage renal disease (ESRD) in developed countries. Several trace elements were reported to be changed in diabetic nephropathy.

Objectives: The aim of this study was to investigate changes in serum levels of zinc, copper and chromium and their association with the incidence of ESRD in patients with diabetes.

Patients and methods: This study was performed on 70 patients with type 2 diabetic nephropathy (macro and micro-albuminuria) and 70 healthy individuals. Samples were collected to survey metals by atomic absorption spectrophotometer. Data was analyzed by SPSS18 using descriptive and inferential analysis methods.

Results: Mean ± SD levels of Zn, Cu and Cr were significantly decreased in blood samples of patients compared to healthy subjects (P < 0.01). Also the mean concentrations of Cu, Zn and Cr in drinking water of Sari were lower than the accepted limit. Only in one case, Cu was higher than the accepted limit, which was the possibility of contamination by water supply pipes.

Conclusions: Cu, Zn and Cr play a specific role in the pathophysiology of diabetic nephropathy. Meanwhile in these patients, low serum levels of Cu, Zn and Cr were not associated with factors such as drinking water. Possible causes should be sought in other factors like urine, intervention factors in absorption and utilization and individual conditions.

No MeSH data available.


Related in: MedlinePlus

Comparison of Serum Trace Elements Level in Cases With Micro and Macro Albuminuria. Cu and Zn in Patients With Micro-Albuminuria are Significantly Higher than in Those With Macro-AlbuminuriaThere was no significant difference in Cr values in micro and macro albuminuria cases (*, P < 0.05). Errors bars represent standard deviation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4628134&req=5

fig21762: Comparison of Serum Trace Elements Level in Cases With Micro and Macro Albuminuria. Cu and Zn in Patients With Micro-Albuminuria are Significantly Higher than in Those With Macro-AlbuminuriaThere was no significant difference in Cr values in micro and macro albuminuria cases (*, P < 0.05). Errors bars represent standard deviation.

Mentions: Albumin was evaluated on 24-hour urine samples of patients and healthy individuals. Urine protein in micro-albuminuria and macro-albuminuria were 113.43 ± 41.38 mg/dL and 514.35 ± 90.11 mg/dL, respectively. Figure 2 illustrated the comparison of serum trace elements level in patients with micro- and macro-albuminuria.


Comparing the Levels of Trace Elements in Patients With Diabetic Nephropathy and Healthy Individuals.

Makhlough A, Makhlough M, Shokrzadeh M, Mohammadian M, Sedighi O, Faghihan M - Nephrourol Mon (2015)

Comparison of Serum Trace Elements Level in Cases With Micro and Macro Albuminuria. Cu and Zn in Patients With Micro-Albuminuria are Significantly Higher than in Those With Macro-AlbuminuriaThere was no significant difference in Cr values in micro and macro albuminuria cases (*, P < 0.05). Errors bars represent standard deviation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4628134&req=5

fig21762: Comparison of Serum Trace Elements Level in Cases With Micro and Macro Albuminuria. Cu and Zn in Patients With Micro-Albuminuria are Significantly Higher than in Those With Macro-AlbuminuriaThere was no significant difference in Cr values in micro and macro albuminuria cases (*, P < 0.05). Errors bars represent standard deviation.
Mentions: Albumin was evaluated on 24-hour urine samples of patients and healthy individuals. Urine protein in micro-albuminuria and macro-albuminuria were 113.43 ± 41.38 mg/dL and 514.35 ± 90.11 mg/dL, respectively. Figure 2 illustrated the comparison of serum trace elements level in patients with micro- and macro-albuminuria.

Bottom Line: Mean ± SD levels of Zn, Cu and Cr were significantly decreased in blood samples of patients compared to healthy subjects (P < 0.01).Meanwhile in these patients, low serum levels of Cu, Zn and Cr were not associated with factors such as drinking water.Possible causes should be sought in other factors like urine, intervention factors in absorption and utilization and individual conditions.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology, Diabetic Research Center of Mazandaran University of Medical Sciences, Sari, IR Iran.

ABSTRACT

Background: Diabetic nephropathy is the most common cause of end stage renal disease (ESRD) in developed countries. Several trace elements were reported to be changed in diabetic nephropathy.

Objectives: The aim of this study was to investigate changes in serum levels of zinc, copper and chromium and their association with the incidence of ESRD in patients with diabetes.

Patients and methods: This study was performed on 70 patients with type 2 diabetic nephropathy (macro and micro-albuminuria) and 70 healthy individuals. Samples were collected to survey metals by atomic absorption spectrophotometer. Data was analyzed by SPSS18 using descriptive and inferential analysis methods.

Results: Mean ± SD levels of Zn, Cu and Cr were significantly decreased in blood samples of patients compared to healthy subjects (P < 0.01). Also the mean concentrations of Cu, Zn and Cr in drinking water of Sari were lower than the accepted limit. Only in one case, Cu was higher than the accepted limit, which was the possibility of contamination by water supply pipes.

Conclusions: Cu, Zn and Cr play a specific role in the pathophysiology of diabetic nephropathy. Meanwhile in these patients, low serum levels of Cu, Zn and Cr were not associated with factors such as drinking water. Possible causes should be sought in other factors like urine, intervention factors in absorption and utilization and individual conditions.

No MeSH data available.


Related in: MedlinePlus