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Whole body vibration therapy: a novel potential treatment for type 2 diabetes mellitus.

Yin H, Berdel HO, Moore D, Davis F, Liu J, Mozaffari M, Yu JC, Baban B - Springerplus (2015)

Bottom Line: Pro-inflammatory changes were significantly reduced, as indicated by reduced IL-17 but increased Foxp3 expression.Collectively, our findings suggest that daily, short duration WBV may improve glycemic control, polydipsia, polyuria, and urine osmolality in T2DM in association with reduced inflammation.Thus, WBV may be a viable adjunctive treatment strategy in T2DM.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Biology, Georgia Regents University, Building: CL 2140, 1120 15th Street, Augusta, GA 30912 USA ; Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Peking, China.

ABSTRACT
There is a worsening epidemic of obesity and diabetes in the world. Life style interventions including dietary changes and increase in exercise can improve glucose metabolism and health in general. However, standard exercise programs are strenuous, time-consuming, and thus have low long-term compliance issues. We tested the feasibility of using high frequency, low amplitude whole body vibration (WBV) therapy to improve glucose metabolism in young type 2 diabetic (T2DM) mice. We also aimed to investigate the postulated anti-inflammatory and cytoprotective properties of WBV. Male db/db and db/m mice were exposed to high frequency, low-amplitude WBV. Outcome parameters comprised of body weight, hemoglobin A1c (HbA1c) level, as well as interleukin (IL)-17 (a marker of helper T cells), forkhead box P3 (Foxp3; a marker of regulatory T cells), and gammaH2AX (an index of DNA injury) expression. Furthermore, a 24 h metabolic cage study was carried out immediately after the WBV protocol and fluid intake, urine excretion and urine osmolality were determined. WBV did not affect body weight but improved HbA1c levels in db/db mice. Vibrated db/db mice demonstrated less fluid intake and urine excretion but better urinary concentrating ability than their non-vibrated controls. Pro-inflammatory changes were significantly reduced, as indicated by reduced IL-17 but increased Foxp3 expression. WBV reduced gammaH2AX in db/db mice suggestive of cytoprotective effect. However, WBV was largely without significant effects on assessed parameters in db/m mice. Collectively, our findings suggest that daily, short duration WBV may improve glycemic control, polydipsia, polyuria, and urine osmolality in T2DM in association with reduced inflammation. Thus, WBV may be a viable adjunctive treatment strategy in T2DM.

No MeSH data available.


Related in: MedlinePlus

Body weight was significantly (p < 0.05) higher in db/db than db/m mice during the course of the study; data are mean ± SD of 6 animals/group
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Fig2: Body weight was significantly (p < 0.05) higher in db/db than db/m mice during the course of the study; data are mean ± SD of 6 animals/group

Mentions: As expected, body weight of db/m mice was significantly (p < 0.05) lower than that of db/db mice during the course of the study (Fig. 2). Vibrated db/db mice displayed a reduction, albeit non-significant, in body weight after 1 week of WBV. Thereafter, however, body weight was similar between vibrated and non-vibrated db/db mice. Similar to db/db mice, WBV did not markedly affect body weight of db/m mice.Fig. 2


Whole body vibration therapy: a novel potential treatment for type 2 diabetes mellitus.

Yin H, Berdel HO, Moore D, Davis F, Liu J, Mozaffari M, Yu JC, Baban B - Springerplus (2015)

Body weight was significantly (p < 0.05) higher in db/db than db/m mice during the course of the study; data are mean ± SD of 6 animals/group
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4628131&req=5

Fig2: Body weight was significantly (p < 0.05) higher in db/db than db/m mice during the course of the study; data are mean ± SD of 6 animals/group
Mentions: As expected, body weight of db/m mice was significantly (p < 0.05) lower than that of db/db mice during the course of the study (Fig. 2). Vibrated db/db mice displayed a reduction, albeit non-significant, in body weight after 1 week of WBV. Thereafter, however, body weight was similar between vibrated and non-vibrated db/db mice. Similar to db/db mice, WBV did not markedly affect body weight of db/m mice.Fig. 2

Bottom Line: Pro-inflammatory changes were significantly reduced, as indicated by reduced IL-17 but increased Foxp3 expression.Collectively, our findings suggest that daily, short duration WBV may improve glycemic control, polydipsia, polyuria, and urine osmolality in T2DM in association with reduced inflammation.Thus, WBV may be a viable adjunctive treatment strategy in T2DM.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Biology, Georgia Regents University, Building: CL 2140, 1120 15th Street, Augusta, GA 30912 USA ; Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Peking, China.

ABSTRACT
There is a worsening epidemic of obesity and diabetes in the world. Life style interventions including dietary changes and increase in exercise can improve glucose metabolism and health in general. However, standard exercise programs are strenuous, time-consuming, and thus have low long-term compliance issues. We tested the feasibility of using high frequency, low amplitude whole body vibration (WBV) therapy to improve glucose metabolism in young type 2 diabetic (T2DM) mice. We also aimed to investigate the postulated anti-inflammatory and cytoprotective properties of WBV. Male db/db and db/m mice were exposed to high frequency, low-amplitude WBV. Outcome parameters comprised of body weight, hemoglobin A1c (HbA1c) level, as well as interleukin (IL)-17 (a marker of helper T cells), forkhead box P3 (Foxp3; a marker of regulatory T cells), and gammaH2AX (an index of DNA injury) expression. Furthermore, a 24 h metabolic cage study was carried out immediately after the WBV protocol and fluid intake, urine excretion and urine osmolality were determined. WBV did not affect body weight but improved HbA1c levels in db/db mice. Vibrated db/db mice demonstrated less fluid intake and urine excretion but better urinary concentrating ability than their non-vibrated controls. Pro-inflammatory changes were significantly reduced, as indicated by reduced IL-17 but increased Foxp3 expression. WBV reduced gammaH2AX in db/db mice suggestive of cytoprotective effect. However, WBV was largely without significant effects on assessed parameters in db/m mice. Collectively, our findings suggest that daily, short duration WBV may improve glycemic control, polydipsia, polyuria, and urine osmolality in T2DM in association with reduced inflammation. Thus, WBV may be a viable adjunctive treatment strategy in T2DM.

No MeSH data available.


Related in: MedlinePlus