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A case of co-existing paraganglioma and thymoma.

Bano G, Sennik D, Kenchaiah M, Kyaw Y, Snape K, Tripathi V, Wilson P, Vlahos I, Hunt I, Hodgson S - Springerplus (2015)

Bottom Line: After treatment her constitutional symptoms improved.The first case reported was bilateral carotid body tumour, thyroid gland adenoma and thymoma.This case also highlights the importance of long term surveillance, multidisciplinary management and being aware of associated pathologies in patients with isolated paraganglioma.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Diabetes, Thomas Addison Unit, St George's Healthcare NHS Trust, Blackshaw Road, Tooting, London, SW17 0QT UK.

ABSTRACT

Background: Head and neck paragangliomas are rare tumours and can arise as a part of inherited syndromes. Their association with thymic tumour is not well known.

Case description: This report describes a female patient who presented with right sided neck paragangliomas. The histology of the tumour was consistent with paraganlioma. Few years later her MRI scan of the chest revealed presence of an anterior mediastinal mass that corresponded to the location of the thymus. Review of her previous scans showed that the mass was present all along and had gradually increased in size. Patient developed symptoms including fatigue, dyspnoea, migratory polyarthritis, Raynaud's phenomenon and erythema nodosum. She had sternotomy and excision of mediastinal mass. The histology was consistent with cortical thymoma (WHO type B2) and she had radiotherapy. After treatment her constitutional symptoms improved. Her paraganglioma susceptibility genes are negative.

Discussion and evaluation: To our knowledge this is only the second case report in the literature of coexistence of carotid body tumour and thymoma. The first case reported was bilateral carotid body tumour, thyroid gland adenoma and thymoma. This case also highlights the importance of long term surveillance, multidisciplinary management and being aware of associated pathologies in patients with isolated paraganglioma.

No MeSH data available.


Related in: MedlinePlus

Increase in the size of mediastinal mass
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Fig4: Increase in the size of mediastinal mass

Mentions: Five years later she was seen in Genetic Endocrine clinic and had an ultrasound scan of the neck, MRI scan of the abdomen and thorax as a part of screening for paraganglioma follow up. MRI scan revealed the presence of a 4 × 2 cm anterior mediastinal mass (Fig. 3). This mass corresponded to the location of the thymus and had central calcification. Review of her previous CT pulmonary angiogram (CTPA) done following her neck surgery 5 years earlier revealed that the mass was eve present on this scan. This mass had only marginally increased in size during this time (Fig. 4). It was decided to manage it conservatively and follow up with serial MRI scans. She had normal concentrations of urinary fractionated metanephrines.Fig. 3


A case of co-existing paraganglioma and thymoma.

Bano G, Sennik D, Kenchaiah M, Kyaw Y, Snape K, Tripathi V, Wilson P, Vlahos I, Hunt I, Hodgson S - Springerplus (2015)

Increase in the size of mediastinal mass
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4628025&req=5

Fig4: Increase in the size of mediastinal mass
Mentions: Five years later she was seen in Genetic Endocrine clinic and had an ultrasound scan of the neck, MRI scan of the abdomen and thorax as a part of screening for paraganglioma follow up. MRI scan revealed the presence of a 4 × 2 cm anterior mediastinal mass (Fig. 3). This mass corresponded to the location of the thymus and had central calcification. Review of her previous CT pulmonary angiogram (CTPA) done following her neck surgery 5 years earlier revealed that the mass was eve present on this scan. This mass had only marginally increased in size during this time (Fig. 4). It was decided to manage it conservatively and follow up with serial MRI scans. She had normal concentrations of urinary fractionated metanephrines.Fig. 3

Bottom Line: After treatment her constitutional symptoms improved.The first case reported was bilateral carotid body tumour, thyroid gland adenoma and thymoma.This case also highlights the importance of long term surveillance, multidisciplinary management and being aware of associated pathologies in patients with isolated paraganglioma.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Diabetes, Thomas Addison Unit, St George's Healthcare NHS Trust, Blackshaw Road, Tooting, London, SW17 0QT UK.

ABSTRACT

Background: Head and neck paragangliomas are rare tumours and can arise as a part of inherited syndromes. Their association with thymic tumour is not well known.

Case description: This report describes a female patient who presented with right sided neck paragangliomas. The histology of the tumour was consistent with paraganlioma. Few years later her MRI scan of the chest revealed presence of an anterior mediastinal mass that corresponded to the location of the thymus. Review of her previous scans showed that the mass was present all along and had gradually increased in size. Patient developed symptoms including fatigue, dyspnoea, migratory polyarthritis, Raynaud's phenomenon and erythema nodosum. She had sternotomy and excision of mediastinal mass. The histology was consistent with cortical thymoma (WHO type B2) and she had radiotherapy. After treatment her constitutional symptoms improved. Her paraganglioma susceptibility genes are negative.

Discussion and evaluation: To our knowledge this is only the second case report in the literature of coexistence of carotid body tumour and thymoma. The first case reported was bilateral carotid body tumour, thyroid gland adenoma and thymoma. This case also highlights the importance of long term surveillance, multidisciplinary management and being aware of associated pathologies in patients with isolated paraganglioma.

No MeSH data available.


Related in: MedlinePlus