Limits...
Long-term outcomes of colectomy surgery among patients with ulcerative colitis.

Brown C, Gibson PR, Hart A, Kaplan GG, Kachroo S, Ding Q, Hautamaki E, Fan T, Black CM, Hu X, Beusterien K - Springerplus (2015)

Bottom Line: Although most respondents (84 %) reported improved quality of life compared to the status before surgery, 81 % experienced problems in at least one of the following areas: depression, work productivity, restrictions in diet, body image, and sexual function.Among moderate to severe UC patients pre-colectomy, 27 % of men and 28 % of women reported that their sexual life was worse now than before surgery.The mean EQ-5D utility index score overall was 0.79 (95 % confidence interval 0.77-0.81).

View Article: PubMed Central - PubMed

Affiliation: Division of General Surgery, Providence Health Care, St. Paul's Hospital, Room C310, St Paul's Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6 Canada.

ABSTRACT
The objective of this study was to evaluate long-term health-related quality of life outcomes among patients who had a colectomy within the previous 10 years. A cross-sectional survey was administered to consecutive patients ≥18 years of age with ulcerative colitis who had a colectomy within the last 10 years from centers in Canada, Australia, and the United Kingdom. Data were extracted from medical chart reviews to confirm selected self-reported patient characteristics. Of 351 survey respondents, 49 % were male and the median age was 40 years (interquartile range 30-52). Respondents were diagnosed with UC a median of 9.2 (5.7-15.1) years prior to the survey and first surgery occurred a median of 3.7 (2.1-5.8) years ago. Although most respondents (84 %) reported improved quality of life compared to the status before surgery, 81 % experienced problems in at least one of the following areas: depression, work productivity, restrictions in diet, body image, and sexual function. According to HADS scores, 30 and 17 % of survey respondents experienced anxiety and depression, respectively. Among moderate to severe UC patients pre-colectomy, 27 % of men and 28 % of women reported that their sexual life was worse now than before surgery. The mean EQ-5D utility index score overall was 0.79 (95 % confidence interval 0.77-0.81). Quality of life after colectomy for UC is generally good, but there are persistent quality of life issues that impact multiple domains, including psychological and sexual functioning.

No MeSH data available.


Related in: MedlinePlus

Flowchart of the Patients who were included in the statistical analysis
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4628015&req=5

Fig1: Flowchart of the Patients who were included in the statistical analysis

Mentions: The surveys were sent to 743 eligible patients who met the inclusion criteria and 424 patients (57 %) returned the surveys. However, 73 patients were excluded from analysis because of incomplete key information for primary objectives in the questionnaire (Fig. 1). Thus, a total of 351 patients with complete surveys were included in the analysis, including 126 in Canada, 126 in the UK, and 99 in Australia. Demographics and clinical characteristics are presented in Table 1. Of survey respondents (n = 351) 49 % were male and the median age was 40 years (interquartile range 30–52). Respondents were diagnosed with UC a median of 9.2 (5.7–15.1) years prior to the survey and first surgery occurred a median of 3.7 (2.1–5.8) years ago. The majority of respondents reported moderate to severe UC prior to surgery. Approximately one-third (32 %) had a stoma at some time after the creation of the ileal pouch and 36 % reported a history of pouch complications.Fig. 1


Long-term outcomes of colectomy surgery among patients with ulcerative colitis.

Brown C, Gibson PR, Hart A, Kaplan GG, Kachroo S, Ding Q, Hautamaki E, Fan T, Black CM, Hu X, Beusterien K - Springerplus (2015)

Flowchart of the Patients who were included in the statistical analysis
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4628015&req=5

Fig1: Flowchart of the Patients who were included in the statistical analysis
Mentions: The surveys were sent to 743 eligible patients who met the inclusion criteria and 424 patients (57 %) returned the surveys. However, 73 patients were excluded from analysis because of incomplete key information for primary objectives in the questionnaire (Fig. 1). Thus, a total of 351 patients with complete surveys were included in the analysis, including 126 in Canada, 126 in the UK, and 99 in Australia. Demographics and clinical characteristics are presented in Table 1. Of survey respondents (n = 351) 49 % were male and the median age was 40 years (interquartile range 30–52). Respondents were diagnosed with UC a median of 9.2 (5.7–15.1) years prior to the survey and first surgery occurred a median of 3.7 (2.1–5.8) years ago. The majority of respondents reported moderate to severe UC prior to surgery. Approximately one-third (32 %) had a stoma at some time after the creation of the ileal pouch and 36 % reported a history of pouch complications.Fig. 1

Bottom Line: Although most respondents (84 %) reported improved quality of life compared to the status before surgery, 81 % experienced problems in at least one of the following areas: depression, work productivity, restrictions in diet, body image, and sexual function.Among moderate to severe UC patients pre-colectomy, 27 % of men and 28 % of women reported that their sexual life was worse now than before surgery.The mean EQ-5D utility index score overall was 0.79 (95 % confidence interval 0.77-0.81).

View Article: PubMed Central - PubMed

Affiliation: Division of General Surgery, Providence Health Care, St. Paul's Hospital, Room C310, St Paul's Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6 Canada.

ABSTRACT
The objective of this study was to evaluate long-term health-related quality of life outcomes among patients who had a colectomy within the previous 10 years. A cross-sectional survey was administered to consecutive patients ≥18 years of age with ulcerative colitis who had a colectomy within the last 10 years from centers in Canada, Australia, and the United Kingdom. Data were extracted from medical chart reviews to confirm selected self-reported patient characteristics. Of 351 survey respondents, 49 % were male and the median age was 40 years (interquartile range 30-52). Respondents were diagnosed with UC a median of 9.2 (5.7-15.1) years prior to the survey and first surgery occurred a median of 3.7 (2.1-5.8) years ago. Although most respondents (84 %) reported improved quality of life compared to the status before surgery, 81 % experienced problems in at least one of the following areas: depression, work productivity, restrictions in diet, body image, and sexual function. According to HADS scores, 30 and 17 % of survey respondents experienced anxiety and depression, respectively. Among moderate to severe UC patients pre-colectomy, 27 % of men and 28 % of women reported that their sexual life was worse now than before surgery. The mean EQ-5D utility index score overall was 0.79 (95 % confidence interval 0.77-0.81). Quality of life after colectomy for UC is generally good, but there are persistent quality of life issues that impact multiple domains, including psychological and sexual functioning.

No MeSH data available.


Related in: MedlinePlus