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Sildenafil treatment attenuates ventricular remodeling in an experimental model of aortic regurgitation.

Eskesen K, Olsen NT, Dimaano VL, Fritz-Hansen T, Sogaard P, Chakir K, Steenbergen C, Kass D, Abraham TP - Springerplus (2015)

Bottom Line: Fractional shortening was improved by treatment (p < 0.05).Myocardial fibrosis was borderline decreased by treatment (p = 0.09).Akt was increased in treated compared to controls (p < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Johns Hopkins Medical Institutions, Division of Cardiology, Baltimore, MD USA ; Department of Cardiology, Gentofte Hospital, University of Copenhagen, Niels Andersensvej 65, 2900 Hellerup, Denmark.

ABSTRACT

Background: Currently there is no reliable medical treatment for aortic regurgitation (AR).

Methods: Thirty-nine Sprague-Dawley rats underwent creation of AR or sham operation. Treated rats were assigned to early or late institution of sildenafil therapy (100 mg/kg/day) for a total of 10 weeks. Treatment-effects were measured by serial echocardiography, invasive hemodynamic measurements, and tissue analysis.

Results: Rats assigned to early treatment developed less remodeling than untreated rats. Thus, left ventricular (LV) dilation was blunted by sildenafil with end-systolic diameter being significantly smaller (6.6 ± 0.4 vs. 7.7 ± 0.4 mm, respectively, p < 0.05). Also, LV wall thickness was significantly decreased in treated rats compared to controls (2.23 ± 0.08 vs. 2.16 ± 0.05 mm, p < 0.01). Fractional shortening was improved by treatment (p < 0.05). Myocardial fibrosis was borderline decreased by treatment (p = 0.09). Akt was increased in treated compared to controls (p < 0.05).

Conclusion: Sildenafil slightly inhibits LV remodeling and improves fractional shortening in rats with AR when treatment is initiated early.

No MeSH data available.


Related in: MedlinePlus

Left ventricle function. LV function in early (upper panel) and late (lower panel) treated groups measured by fractional shortening (FS) (left) and by speckle tracking (right). Asterisk indicate significant difference between AR vs. AR + SIL and hash indicate difference between sham vs. AR at individual time points (t test/ANOVA). Vertical bar and related p value is for overall difference (repeated measures)
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Fig3: Left ventricle function. LV function in early (upper panel) and late (lower panel) treated groups measured by fractional shortening (FS) (left) and by speckle tracking (right). Asterisk indicate significant difference between AR vs. AR + SIL and hash indicate difference between sham vs. AR at individual time points (t test/ANOVA). Vertical bar and related p value is for overall difference (repeated measures)

Mentions: As seen in Fig. 3 conventional echocardiographic measures of LV function showed less decrease in FS in AR + SIL (early) than in AR (early) after 12 weeks and in overall analysis (p = 0.01). We did not find any difference in LV performance measured by speckle tracking echocardiography.Fig. 3


Sildenafil treatment attenuates ventricular remodeling in an experimental model of aortic regurgitation.

Eskesen K, Olsen NT, Dimaano VL, Fritz-Hansen T, Sogaard P, Chakir K, Steenbergen C, Kass D, Abraham TP - Springerplus (2015)

Left ventricle function. LV function in early (upper panel) and late (lower panel) treated groups measured by fractional shortening (FS) (left) and by speckle tracking (right). Asterisk indicate significant difference between AR vs. AR + SIL and hash indicate difference between sham vs. AR at individual time points (t test/ANOVA). Vertical bar and related p value is for overall difference (repeated measures)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4628012&req=5

Fig3: Left ventricle function. LV function in early (upper panel) and late (lower panel) treated groups measured by fractional shortening (FS) (left) and by speckle tracking (right). Asterisk indicate significant difference between AR vs. AR + SIL and hash indicate difference between sham vs. AR at individual time points (t test/ANOVA). Vertical bar and related p value is for overall difference (repeated measures)
Mentions: As seen in Fig. 3 conventional echocardiographic measures of LV function showed less decrease in FS in AR + SIL (early) than in AR (early) after 12 weeks and in overall analysis (p = 0.01). We did not find any difference in LV performance measured by speckle tracking echocardiography.Fig. 3

Bottom Line: Fractional shortening was improved by treatment (p < 0.05).Myocardial fibrosis was borderline decreased by treatment (p = 0.09).Akt was increased in treated compared to controls (p < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Johns Hopkins Medical Institutions, Division of Cardiology, Baltimore, MD USA ; Department of Cardiology, Gentofte Hospital, University of Copenhagen, Niels Andersensvej 65, 2900 Hellerup, Denmark.

ABSTRACT

Background: Currently there is no reliable medical treatment for aortic regurgitation (AR).

Methods: Thirty-nine Sprague-Dawley rats underwent creation of AR or sham operation. Treated rats were assigned to early or late institution of sildenafil therapy (100 mg/kg/day) for a total of 10 weeks. Treatment-effects were measured by serial echocardiography, invasive hemodynamic measurements, and tissue analysis.

Results: Rats assigned to early treatment developed less remodeling than untreated rats. Thus, left ventricular (LV) dilation was blunted by sildenafil with end-systolic diameter being significantly smaller (6.6 ± 0.4 vs. 7.7 ± 0.4 mm, respectively, p < 0.05). Also, LV wall thickness was significantly decreased in treated rats compared to controls (2.23 ± 0.08 vs. 2.16 ± 0.05 mm, p < 0.01). Fractional shortening was improved by treatment (p < 0.05). Myocardial fibrosis was borderline decreased by treatment (p = 0.09). Akt was increased in treated compared to controls (p < 0.05).

Conclusion: Sildenafil slightly inhibits LV remodeling and improves fractional shortening in rats with AR when treatment is initiated early.

No MeSH data available.


Related in: MedlinePlus