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Disrupted normal ingestion during glucose intake modulates glucose kinetics in humans.

Tsuji T, Tanaka S, Kida K, Bakhshishayan S, Kogo M, Yamamoto T - Springerplus (2015)

Bottom Line: The glucose-loading test was applied to seven healthy individuals.Three successive oral glucose-loadings induced a gradual downward shift in the blood glucose curves (BGC) together with increased salivary α-amylase activity (s-AMY) and positively correlated with satisfaction scores.The present study suggests that disrupted normal ingestion during glucose intake modulates glucose kinetics along with increased s-AMY values, indicating enhanced sympathetic nervous activity and favorable chemical senses are important in maintaining glucose kinetics.

View Article: PubMed Central - PubMed

Affiliation: First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, 1-8 Yamadaoka, Suita City, Osaka 565-0871 Japan.

ABSTRACT
This study aims to reveal the importance of chemical senses in glucose kinetics and autonomic nervous activity by imposing interventions during glucose intake. The glucose-loading test was applied to seven healthy individuals. Three successive oral glucose-loadings induced a gradual downward shift in the blood glucose curves (BGC) together with increased salivary α-amylase activity (s-AMY) and positively correlated with satisfaction scores. On the other hands, adding a pleasant flavor given during the third trial increased the BGC to the same level as that during the first loading with decreased s-AMY value. Direct intragastric delivery of glucose or clipping the nose induced a downward shift in both BGC and serum insulin response curves (IRC), resulting in a decrease of the area under the BGC, positively correlated with the area under the IRC and satisfaction scores, respectively. The present study suggests that disrupted normal ingestion during glucose intake modulates glucose kinetics along with increased s-AMY values, indicating enhanced sympathetic nervous activity and favorable chemical senses are important in maintaining glucose kinetics.

No MeSH data available.


Related in: MedlinePlus

Correlations among area under blood glucose curves, salivary α-amylase activity and satisfaction scores. a AUBGC correlates with satisfaction score (P < 0.001); b post-loading s-AMY expressed as ratio of pre-loading value negatively correlates with AUBGC (P = 0.015). N = 24, Spearman’s rank-correlation coefficient tests. AUBGC area under blood glucose curve, s-AMY salivary α-amylase
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Fig1: Correlations among area under blood glucose curves, salivary α-amylase activity and satisfaction scores. a AUBGC correlates with satisfaction score (P < 0.001); b post-loading s-AMY expressed as ratio of pre-loading value negatively correlates with AUBGC (P = 0.015). N = 24, Spearman’s rank-correlation coefficient tests. AUBGC area under blood glucose curve, s-AMY salivary α-amylase

Mentions: Figure 1a shows a significant positive correlation (r = 0.88, P < 0.001) between AUBGC and satisfaction scores, indicating that the downward shift of the BGC closely corresponded to a decrease in satisfaction. The AUBGC and s-AMY ratio negatively correlated (r = −0.51, P = 0.015), indicating that AUBGC decreased as s-AMY increased (Fig. 1b).Fig. 1


Disrupted normal ingestion during glucose intake modulates glucose kinetics in humans.

Tsuji T, Tanaka S, Kida K, Bakhshishayan S, Kogo M, Yamamoto T - Springerplus (2015)

Correlations among area under blood glucose curves, salivary α-amylase activity and satisfaction scores. a AUBGC correlates with satisfaction score (P < 0.001); b post-loading s-AMY expressed as ratio of pre-loading value negatively correlates with AUBGC (P = 0.015). N = 24, Spearman’s rank-correlation coefficient tests. AUBGC area under blood glucose curve, s-AMY salivary α-amylase
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4627997&req=5

Fig1: Correlations among area under blood glucose curves, salivary α-amylase activity and satisfaction scores. a AUBGC correlates with satisfaction score (P < 0.001); b post-loading s-AMY expressed as ratio of pre-loading value negatively correlates with AUBGC (P = 0.015). N = 24, Spearman’s rank-correlation coefficient tests. AUBGC area under blood glucose curve, s-AMY salivary α-amylase
Mentions: Figure 1a shows a significant positive correlation (r = 0.88, P < 0.001) between AUBGC and satisfaction scores, indicating that the downward shift of the BGC closely corresponded to a decrease in satisfaction. The AUBGC and s-AMY ratio negatively correlated (r = −0.51, P = 0.015), indicating that AUBGC decreased as s-AMY increased (Fig. 1b).Fig. 1

Bottom Line: The glucose-loading test was applied to seven healthy individuals.Three successive oral glucose-loadings induced a gradual downward shift in the blood glucose curves (BGC) together with increased salivary α-amylase activity (s-AMY) and positively correlated with satisfaction scores.The present study suggests that disrupted normal ingestion during glucose intake modulates glucose kinetics along with increased s-AMY values, indicating enhanced sympathetic nervous activity and favorable chemical senses are important in maintaining glucose kinetics.

View Article: PubMed Central - PubMed

Affiliation: First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, 1-8 Yamadaoka, Suita City, Osaka 565-0871 Japan.

ABSTRACT
This study aims to reveal the importance of chemical senses in glucose kinetics and autonomic nervous activity by imposing interventions during glucose intake. The glucose-loading test was applied to seven healthy individuals. Three successive oral glucose-loadings induced a gradual downward shift in the blood glucose curves (BGC) together with increased salivary α-amylase activity (s-AMY) and positively correlated with satisfaction scores. On the other hands, adding a pleasant flavor given during the third trial increased the BGC to the same level as that during the first loading with decreased s-AMY value. Direct intragastric delivery of glucose or clipping the nose induced a downward shift in both BGC and serum insulin response curves (IRC), resulting in a decrease of the area under the BGC, positively correlated with the area under the IRC and satisfaction scores, respectively. The present study suggests that disrupted normal ingestion during glucose intake modulates glucose kinetics along with increased s-AMY values, indicating enhanced sympathetic nervous activity and favorable chemical senses are important in maintaining glucose kinetics.

No MeSH data available.


Related in: MedlinePlus