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The Association Between Primary Open Angle Glaucoma and Clustered Components of Metabolic Syndrome.

Rasoulinejad SA, Kasiri A, Montazeri M, Rashidi N, Montazeri M, Montazeri M, Hedayati H - Open Ophthalmol J (2015)

Bottom Line: MetS was associated with an increased odds ratio for an IOP higher than 21 mmHg (OR: 1.72; 95% CI 1.03-2.79; p=0.034).The mechanisms underlying these associations need to be established in future studies.Our results support the recommendation that patients with metabolic syndrome undergo regular ophthalmological exams to monitor for the onset or progression of glaucoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Babol University of Medical Sciences, Babol, Iran.

ABSTRACT

Purpose: There is conflicting evidence whether components of metabolic syndrome (MetS) increase or decrease the risk of primary open-angle glaucoma (POAG). The aim of the present study was to determine the association between metabolic syndrome and primary open-angle glaucoma.

Methods: A total of 200 participants comprising 100 controls and 100 patients with POAG documented by clinical tests and examined by an experienced ophthalmologist using standard ophthalmologic equipment were included in the study. MetS was defined and based on ATP III criteria and POAG was defined by the criteria of the International Society of Geographic and Epidemiological Ophthalmology (ISGEO). The data were entered into the SPSS software and analyzed.

Results: The prevalence of MetS in the glaucoma group was 53% in comparison to 38% in the control group (p=0.037). MetS was associated with an increased odds ratio for an IOP higher than 21 mmHg (OR: 1.72; 95% CI 1.03-2.79; p=0.034). The mean IOP was 24.91±4.29 mmHg in the patients without MetS, and 27.23±4.81 mmHg in those with MetS (p=0.027). The mean values of CCT were 603.64±63.16 µm in MetS patients and 579.27±72.87 µm in controls (p=0.018).

Conclusion: Data showed an increased prevalence of components of metabolic syndrome in patients with glaucoma. The mechanisms underlying these associations need to be established in future studies. Our results support the recommendation that patients with metabolic syndrome undergo regular ophthalmological exams to monitor for the onset or progression of glaucoma.

No MeSH data available.


Related in: MedlinePlus

Metabolic syndrome components frequency in patients with glaucoma.
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Figure 1: Metabolic syndrome components frequency in patients with glaucoma.

Mentions: Fig. (1) shows that only one percent of the glaucoma patients had no metabolic syndrome component, while 12 percent had all 5 components. The odds for glaucoma seem to vary for different components of MetS, and the risk estimate increased as the number of components of MetS increased from 1 to 5. As shown in Table 4, individuals with 4 and 5 components of the MetS had an increased OR for glaucoma: 3.76 (95% CI, 2.15-4.64) and 5.12 (95% CI, 1.58-8.39), respectively, compared with individuals with none of the components.


The Association Between Primary Open Angle Glaucoma and Clustered Components of Metabolic Syndrome.

Rasoulinejad SA, Kasiri A, Montazeri M, Rashidi N, Montazeri M, Montazeri M, Hedayati H - Open Ophthalmol J (2015)

Metabolic syndrome components frequency in patients with glaucoma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4627385&req=5

Figure 1: Metabolic syndrome components frequency in patients with glaucoma.
Mentions: Fig. (1) shows that only one percent of the glaucoma patients had no metabolic syndrome component, while 12 percent had all 5 components. The odds for glaucoma seem to vary for different components of MetS, and the risk estimate increased as the number of components of MetS increased from 1 to 5. As shown in Table 4, individuals with 4 and 5 components of the MetS had an increased OR for glaucoma: 3.76 (95% CI, 2.15-4.64) and 5.12 (95% CI, 1.58-8.39), respectively, compared with individuals with none of the components.

Bottom Line: MetS was associated with an increased odds ratio for an IOP higher than 21 mmHg (OR: 1.72; 95% CI 1.03-2.79; p=0.034).The mechanisms underlying these associations need to be established in future studies.Our results support the recommendation that patients with metabolic syndrome undergo regular ophthalmological exams to monitor for the onset or progression of glaucoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Babol University of Medical Sciences, Babol, Iran.

ABSTRACT

Purpose: There is conflicting evidence whether components of metabolic syndrome (MetS) increase or decrease the risk of primary open-angle glaucoma (POAG). The aim of the present study was to determine the association between metabolic syndrome and primary open-angle glaucoma.

Methods: A total of 200 participants comprising 100 controls and 100 patients with POAG documented by clinical tests and examined by an experienced ophthalmologist using standard ophthalmologic equipment were included in the study. MetS was defined and based on ATP III criteria and POAG was defined by the criteria of the International Society of Geographic and Epidemiological Ophthalmology (ISGEO). The data were entered into the SPSS software and analyzed.

Results: The prevalence of MetS in the glaucoma group was 53% in comparison to 38% in the control group (p=0.037). MetS was associated with an increased odds ratio for an IOP higher than 21 mmHg (OR: 1.72; 95% CI 1.03-2.79; p=0.034). The mean IOP was 24.91±4.29 mmHg in the patients without MetS, and 27.23±4.81 mmHg in those with MetS (p=0.027). The mean values of CCT were 603.64±63.16 µm in MetS patients and 579.27±72.87 µm in controls (p=0.018).

Conclusion: Data showed an increased prevalence of components of metabolic syndrome in patients with glaucoma. The mechanisms underlying these associations need to be established in future studies. Our results support the recommendation that patients with metabolic syndrome undergo regular ophthalmological exams to monitor for the onset or progression of glaucoma.

No MeSH data available.


Related in: MedlinePlus