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Serum VEGF Predicts Worse Clinical Outcome of Patients with Coronary Heart Disease After Percutaneous Coronary Intervention Therapy.

Han X, Liu L, Niu J, Yang J, Zhang Z, Zhang Z - Med. Sci. Monit. (2015)

Bottom Line: VEGF level in CHD patients was significantly lower than that of healthy individuals (P<0.05).In the analysis of basic information, we found differences in sex distribution and hypertension between groups (P<0.05 for both).Low level of VEGF may predict poor clinical outcome of CHD patients after PCI treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Laiwu People's Hospital, Laiwu, Shandong, China (mainland).

ABSTRACT

Background: Percutaneous coronary intervention (PCI) is an effective treatment for coronary heart disease (CHD) patients. However, patients after PCI treatment often have ischemic events that result in poor prognosis. Our study aimed to investigate the effects of vascular endothelial growth factor (VEGF) level on the prognosis of CHD patients.

Material and methods: We enrolled 114 CHD patients in the study. Serum VEGF level was measured by enzyme-linked immunosorbent assay (ELISA). Total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, and Hs-CRP were also tested in patients. The patients were divided into 2 groups according to the level of VEGF. Kaplan-Meier curve was used to observe the differences in survival situation of patients of the 2 groups. Cox regression analysis was conducted to judge whether VEGF was an independent biomarker for prognosis in CHD.

Results: We included 104 patients for survival analysis. VEGF level in CHD patients was significantly lower than that of healthy individuals (P<0.05). In the analysis of basic information, we found differences in sex distribution and hypertension between groups (P<0.05 for both). Kaplan-Meier curve indicated that patients with low expression of VEGF presented with poor prognosis. The mortality rate of the low-expression group was 37.71%, higher than that of the high-expression group (14.3%). Cox analysis suggested that VEGF could serve as a biomarker for prognosis in CHD (HR: 3.014, P: 0.019).

Conclusions: Low level of VEGF may predict poor clinical outcome of CHD patients after PCI treatment.

No MeSH data available.


Related in: MedlinePlus

Serum level of VEGF in CHD patients and healthy controls. VEGF level was significantly downregulated in CHD patients (P<0.05).
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f1-medscimonit-21-3247: Serum level of VEGF in CHD patients and healthy controls. VEGF level was significantly downregulated in CHD patients (P<0.05).

Mentions: We used ELISA technology to test serum level of VEGF. As shown in Figure 1, VEGF level in CHD patients was lower than that in healthy controls (18.88 pg/ml vs. 389.25 pg/ml, P<0.05).


Serum VEGF Predicts Worse Clinical Outcome of Patients with Coronary Heart Disease After Percutaneous Coronary Intervention Therapy.

Han X, Liu L, Niu J, Yang J, Zhang Z, Zhang Z - Med. Sci. Monit. (2015)

Serum level of VEGF in CHD patients and healthy controls. VEGF level was significantly downregulated in CHD patients (P<0.05).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4627363&req=5

f1-medscimonit-21-3247: Serum level of VEGF in CHD patients and healthy controls. VEGF level was significantly downregulated in CHD patients (P<0.05).
Mentions: We used ELISA technology to test serum level of VEGF. As shown in Figure 1, VEGF level in CHD patients was lower than that in healthy controls (18.88 pg/ml vs. 389.25 pg/ml, P<0.05).

Bottom Line: VEGF level in CHD patients was significantly lower than that of healthy individuals (P<0.05).In the analysis of basic information, we found differences in sex distribution and hypertension between groups (P<0.05 for both).Low level of VEGF may predict poor clinical outcome of CHD patients after PCI treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Laiwu People's Hospital, Laiwu, Shandong, China (mainland).

ABSTRACT

Background: Percutaneous coronary intervention (PCI) is an effective treatment for coronary heart disease (CHD) patients. However, patients after PCI treatment often have ischemic events that result in poor prognosis. Our study aimed to investigate the effects of vascular endothelial growth factor (VEGF) level on the prognosis of CHD patients.

Material and methods: We enrolled 114 CHD patients in the study. Serum VEGF level was measured by enzyme-linked immunosorbent assay (ELISA). Total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, and Hs-CRP were also tested in patients. The patients were divided into 2 groups according to the level of VEGF. Kaplan-Meier curve was used to observe the differences in survival situation of patients of the 2 groups. Cox regression analysis was conducted to judge whether VEGF was an independent biomarker for prognosis in CHD.

Results: We included 104 patients for survival analysis. VEGF level in CHD patients was significantly lower than that of healthy individuals (P<0.05). In the analysis of basic information, we found differences in sex distribution and hypertension between groups (P<0.05 for both). Kaplan-Meier curve indicated that patients with low expression of VEGF presented with poor prognosis. The mortality rate of the low-expression group was 37.71%, higher than that of the high-expression group (14.3%). Cox analysis suggested that VEGF could serve as a biomarker for prognosis in CHD (HR: 3.014, P: 0.019).

Conclusions: Low level of VEGF may predict poor clinical outcome of CHD patients after PCI treatment.

No MeSH data available.


Related in: MedlinePlus