Limits...
Interaction between years of education and APOE ε4 status on frontal and temporal metabolism.

Arenaza-Urquijo EM, Gonneaud J, Fouquet M, Perrotin A, Mézenge F, Landeau B, Egret S, De la Sayette V, Desgranges B, Chételat G - Neurology (2015)

Bottom Line: We tested the interaction effect between years of education and APOE ε4 status (carrier vs noncarrier) on FDG-PET and structural MRI within the whole brain (voxel-wise) adjusting for age and sex.Computed florbetapir standardized uptake value ratios were used for complementary analyses.Higher metabolism in higher (compared to lower) educated APOE ε4 carriers was found in regions that sustain episodic memory.

View Article: PubMed Central - PubMed

Affiliation: From INSERM U1077 (E.M.A.-U., J.G., M.F., A.P., F.M., B.L., S.E., V.D.l.S., B.D., G.C.); Université de Caen Basse-Normandie (E.M.A.-U., J.G., M.F., A.P., F.M., B.L., V.D.l.S., B.D., G.C.) and Ecole Pratique des Hautes Etudes (E.M.A.-U., J.G., M.F., A.P., F.M., B.L., V.D.l.S., B.D., G.C.), UMR-S1077; CHU de Caen, U1077 (E.M.A.-U., J.G., M.F., A.P., F.M., B.L., S.E., B.D., G.C.); and CHU de Caen (S.E., V.D.l.S.), Service de Neurologie, Caen, France.

No MeSH data available.


Related in: MedlinePlus

Voxel-wise results and scatterplots of the interaction effect between APOE ε4 status and educationThe number of years of education is plotted against the FDG-PET metabolism of each significant cluster.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4626241&req=5

Figure 1: Voxel-wise results and scatterplots of the interaction effect between APOE ε4 status and educationThe number of years of education is plotted against the FDG-PET metabolism of each significant cluster.

Mentions: No significant interaction was found between years of education and APOE status on gray matter volume. As for FDG-PET, a years of education × APOE ε4 status interaction was found on bilateral parahippocampal/hippocampal, left middle temporal, and right prefrontal metabolism (figure 1). The interaction effect was such that higher education was related to higher metabolism only in APOE ε4 carriers (r = 0.59, p = 0.001; r = 0.45, p = 0.02; r = 0.46, p < 0.01 in the left and right hippocampus and right prefrontal cortex, respectively) but not in the noncarriers (all p > 0.1), except for the left hippocampus, where a negative correlation was found in the noncarriers (r = −0.38, p = 0.01).


Interaction between years of education and APOE ε4 status on frontal and temporal metabolism.

Arenaza-Urquijo EM, Gonneaud J, Fouquet M, Perrotin A, Mézenge F, Landeau B, Egret S, De la Sayette V, Desgranges B, Chételat G - Neurology (2015)

Voxel-wise results and scatterplots of the interaction effect between APOE ε4 status and educationThe number of years of education is plotted against the FDG-PET metabolism of each significant cluster.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4626241&req=5

Figure 1: Voxel-wise results and scatterplots of the interaction effect between APOE ε4 status and educationThe number of years of education is plotted against the FDG-PET metabolism of each significant cluster.
Mentions: No significant interaction was found between years of education and APOE status on gray matter volume. As for FDG-PET, a years of education × APOE ε4 status interaction was found on bilateral parahippocampal/hippocampal, left middle temporal, and right prefrontal metabolism (figure 1). The interaction effect was such that higher education was related to higher metabolism only in APOE ε4 carriers (r = 0.59, p = 0.001; r = 0.45, p = 0.02; r = 0.46, p < 0.01 in the left and right hippocampus and right prefrontal cortex, respectively) but not in the noncarriers (all p > 0.1), except for the left hippocampus, where a negative correlation was found in the noncarriers (r = −0.38, p = 0.01).

Bottom Line: We tested the interaction effect between years of education and APOE ε4 status (carrier vs noncarrier) on FDG-PET and structural MRI within the whole brain (voxel-wise) adjusting for age and sex.Computed florbetapir standardized uptake value ratios were used for complementary analyses.Higher metabolism in higher (compared to lower) educated APOE ε4 carriers was found in regions that sustain episodic memory.

View Article: PubMed Central - PubMed

Affiliation: From INSERM U1077 (E.M.A.-U., J.G., M.F., A.P., F.M., B.L., S.E., V.D.l.S., B.D., G.C.); Université de Caen Basse-Normandie (E.M.A.-U., J.G., M.F., A.P., F.M., B.L., V.D.l.S., B.D., G.C.) and Ecole Pratique des Hautes Etudes (E.M.A.-U., J.G., M.F., A.P., F.M., B.L., V.D.l.S., B.D., G.C.), UMR-S1077; CHU de Caen, U1077 (E.M.A.-U., J.G., M.F., A.P., F.M., B.L., S.E., B.D., G.C.); and CHU de Caen (S.E., V.D.l.S.), Service de Neurologie, Caen, France.

No MeSH data available.


Related in: MedlinePlus