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One-Carbon Metabolic Factors and Risk of Renal Cell Cancer: A Meta-Analysis.

Mao B, Li Y, Zhang Z, Chen C, Chen Y, Ding C, Lei L, Li J, Jiang M, Wang D, Wang G - PLoS ONE (2015)

Bottom Line: In addition, an increase in folic acid supplementation of 100 μg/day was associated with a 3% lower risk of RCC (RR, 0.97; 95%CI: 0.93-1.00; P = 0.048).Similarly, an increase of 5 nmol/L of vitamin B2 was associated with a reduced risk of RCC 0.94 (95%CI: 0.89-1.00; P = 0.045).Sensitivity analyses suggested that a higher serum vitamin B6 might contribute to a reduced risk of RCC (RR, 0.83; 95%CI: 0.77-0.89; P < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Cancer Center, Institute of Surgical Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.

ABSTRACT

Background: Nutrients related to one-carbon metabolism were previously shown to be significantly associated with the risk of cancer. The aim of this meta-analysis was to evaluate potential relationships between one-carbon metabolic factors and renal cell cancer (RCC) risk.

Methods: PubMed, EMBASE, and Cochrane Library databases were searched through March 2015 for observational studies of quantitative RCC risk estimates in relation to one-carbon metabolic factors. The relative risks (RRs) with 95% confidence intervals (CIs) measured the relationship between one-carbon metabolic factors and RCC risk using a random-effects model.

Results: Of the 463 citations and abstracts identified by database search, seven cohorts from five observational studies reported data on 133,995 individuals, and included 2,441 RCC cases. Comparing the highest with the lowest category, the pooled RRs of RCC were 0.72 (95%CI: 0.52-1.00; P = 0.048) for vitamin B12. In addition, an increase in folic acid supplementation of 100 μg/day was associated with a 3% lower risk of RCC (RR, 0.97; 95%CI: 0.93-1.00; P = 0.048). Similarly, an increase of 5 nmol/L of vitamin B2 was associated with a reduced risk of RCC 0.94 (95%CI: 0.89-1.00; P = 0.045). Sensitivity analyses suggested that a higher serum vitamin B6 might contribute to a reduced risk of RCC (RR, 0.83; 95%CI: 0.77-0.89; P < 0.001).

Conclusions: Higher levels of serum vitamin B2, B6, B12, and folic acid supplementation lowered the risk of RCC among the study participants.

No MeSH data available.


Related in: MedlinePlus

Flow diagram outlining the literature search and study selection process.
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pone.0141762.g001: Flow diagram outlining the literature search and study selection process.

Mentions: The primary search produced 463 records. After scanning titles and abstracts, 451 irrelevant articles were excluded. Twelve full-text articles were reviewed, and finally five studies [35–39] with seven cohorts were included in this meta-analysis (Fig 1). A manual search of the reference lists within these studies did not yield any new eligible studies. The general characteristics of the included studies and participants are presented in Table 1.


One-Carbon Metabolic Factors and Risk of Renal Cell Cancer: A Meta-Analysis.

Mao B, Li Y, Zhang Z, Chen C, Chen Y, Ding C, Lei L, Li J, Jiang M, Wang D, Wang G - PLoS ONE (2015)

Flow diagram outlining the literature search and study selection process.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4625965&req=5

pone.0141762.g001: Flow diagram outlining the literature search and study selection process.
Mentions: The primary search produced 463 records. After scanning titles and abstracts, 451 irrelevant articles were excluded. Twelve full-text articles were reviewed, and finally five studies [35–39] with seven cohorts were included in this meta-analysis (Fig 1). A manual search of the reference lists within these studies did not yield any new eligible studies. The general characteristics of the included studies and participants are presented in Table 1.

Bottom Line: In addition, an increase in folic acid supplementation of 100 μg/day was associated with a 3% lower risk of RCC (RR, 0.97; 95%CI: 0.93-1.00; P = 0.048).Similarly, an increase of 5 nmol/L of vitamin B2 was associated with a reduced risk of RCC 0.94 (95%CI: 0.89-1.00; P = 0.045).Sensitivity analyses suggested that a higher serum vitamin B6 might contribute to a reduced risk of RCC (RR, 0.83; 95%CI: 0.77-0.89; P < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Cancer Center, Institute of Surgical Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.

ABSTRACT

Background: Nutrients related to one-carbon metabolism were previously shown to be significantly associated with the risk of cancer. The aim of this meta-analysis was to evaluate potential relationships between one-carbon metabolic factors and renal cell cancer (RCC) risk.

Methods: PubMed, EMBASE, and Cochrane Library databases were searched through March 2015 for observational studies of quantitative RCC risk estimates in relation to one-carbon metabolic factors. The relative risks (RRs) with 95% confidence intervals (CIs) measured the relationship between one-carbon metabolic factors and RCC risk using a random-effects model.

Results: Of the 463 citations and abstracts identified by database search, seven cohorts from five observational studies reported data on 133,995 individuals, and included 2,441 RCC cases. Comparing the highest with the lowest category, the pooled RRs of RCC were 0.72 (95%CI: 0.52-1.00; P = 0.048) for vitamin B12. In addition, an increase in folic acid supplementation of 100 μg/day was associated with a 3% lower risk of RCC (RR, 0.97; 95%CI: 0.93-1.00; P = 0.048). Similarly, an increase of 5 nmol/L of vitamin B2 was associated with a reduced risk of RCC 0.94 (95%CI: 0.89-1.00; P = 0.045). Sensitivity analyses suggested that a higher serum vitamin B6 might contribute to a reduced risk of RCC (RR, 0.83; 95%CI: 0.77-0.89; P < 0.001).

Conclusions: Higher levels of serum vitamin B2, B6, B12, and folic acid supplementation lowered the risk of RCC among the study participants.

No MeSH data available.


Related in: MedlinePlus