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Ebola in West Africa--CDC's Role in Epidemic Detection, Control, and Prevention.

Frieden TR, Damon IK - Emerging Infect. Dis. (2015)

Bottom Line: Since Ebola virus disease was identified in West Africa on March 23, 2014, the Centers for Disease Control and Prevention (CDC) has undertaken the most intensive response in the agency's history; >3,000 staff have been involved, including >1,200 deployed to West Africa for >50,000 person workdays.All efforts were undertaken as part of national and global response activities with many partner organizations.CDC was able to support community, national, and international health and public health staff to prevent an even worse event.

View Article: PubMed Central - PubMed

ABSTRACT
Since Ebola virus disease was identified in West Africa on March 23, 2014, the Centers for Disease Control and Prevention (CDC) has undertaken the most intensive response in the agency's history; >3,000 staff have been involved, including >1,200 deployed to West Africa for >50,000 person workdays. Efforts have included supporting incident management systems in affected countries; mobilizing partners; and strengthening laboratory, epidemiology, contact investigation, health care infection control, communication, and border screening in West Africa, Nigeria, Mali, Senegal, and the United States. All efforts were undertaken as part of national and global response activities with many partner organizations. CDC was able to support community, national, and international health and public health staff to prevent an even worse event. The Ebola virus disease epidemic highlights the need to strengthen national and international systems to detect, respond to, and prevent the spread of future health threats.

No MeSH data available.


Related in: MedlinePlus

Comparison of estimated weekly Ebola virus disease case rate for Liberia with intervention with actual weekly case rates for Liberia and Sierra Leone. The September 2014 modeled projection curve was based on Figures 9 and 10 in Meltzer et al. (22), by using model predictions calculated assuming that interventions started on September 24, 2014. Liberia, week 1 begins May 4, 2014; Sierra Leone, week 1 begins May 25, 2014. The model projected the incidence that would occur if the proportion of Ebola patients who were hospitalized was 25% at week 22, increased to 40% at week 26, and increased again to 70% at week 30, while the proportion in effective home isolation remained constant at 10%. The similarity in the increase and decrease in the actual epidemic curves in both Sierra Leone and Liberia closely match the model after taking into account differences in start dates and population sizes between the 2 countries, implying that the proportion of cases effectively isolated in both countries followed a similar time course as the model.
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Figure 3: Comparison of estimated weekly Ebola virus disease case rate for Liberia with intervention with actual weekly case rates for Liberia and Sierra Leone. The September 2014 modeled projection curve was based on Figures 9 and 10 in Meltzer et al. (22), by using model predictions calculated assuming that interventions started on September 24, 2014. Liberia, week 1 begins May 4, 2014; Sierra Leone, week 1 begins May 25, 2014. The model projected the incidence that would occur if the proportion of Ebola patients who were hospitalized was 25% at week 22, increased to 40% at week 26, and increased again to 70% at week 30, while the proportion in effective home isolation remained constant at 10%. The similarity in the increase and decrease in the actual epidemic curves in both Sierra Leone and Liberia closely match the model after taking into account differences in start dates and population sizes between the 2 countries, implying that the proportion of cases effectively isolated in both countries followed a similar time course as the model.

Mentions: Fourth, the model predicted that when the tipping point was reached, transmission would decline rapidly. This prediction was shown to be accurate in the following months in Liberia and Sierra Leone (Figure 3). For Liberia, the model’s prediction that if urgent action were taken, there would be 10,000–27,000 cumulative cases by January 21, 2015, closely matched the 8,500–24,000 cases that occurred (Figure 4). The predictions also closely matched the actual case trajectory after effective intervention.


Ebola in West Africa--CDC's Role in Epidemic Detection, Control, and Prevention.

Frieden TR, Damon IK - Emerging Infect. Dis. (2015)

Comparison of estimated weekly Ebola virus disease case rate for Liberia with intervention with actual weekly case rates for Liberia and Sierra Leone. The September 2014 modeled projection curve was based on Figures 9 and 10 in Meltzer et al. (22), by using model predictions calculated assuming that interventions started on September 24, 2014. Liberia, week 1 begins May 4, 2014; Sierra Leone, week 1 begins May 25, 2014. The model projected the incidence that would occur if the proportion of Ebola patients who were hospitalized was 25% at week 22, increased to 40% at week 26, and increased again to 70% at week 30, while the proportion in effective home isolation remained constant at 10%. The similarity in the increase and decrease in the actual epidemic curves in both Sierra Leone and Liberia closely match the model after taking into account differences in start dates and population sizes between the 2 countries, implying that the proportion of cases effectively isolated in both countries followed a similar time course as the model.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4622264&req=5

Figure 3: Comparison of estimated weekly Ebola virus disease case rate for Liberia with intervention with actual weekly case rates for Liberia and Sierra Leone. The September 2014 modeled projection curve was based on Figures 9 and 10 in Meltzer et al. (22), by using model predictions calculated assuming that interventions started on September 24, 2014. Liberia, week 1 begins May 4, 2014; Sierra Leone, week 1 begins May 25, 2014. The model projected the incidence that would occur if the proportion of Ebola patients who were hospitalized was 25% at week 22, increased to 40% at week 26, and increased again to 70% at week 30, while the proportion in effective home isolation remained constant at 10%. The similarity in the increase and decrease in the actual epidemic curves in both Sierra Leone and Liberia closely match the model after taking into account differences in start dates and population sizes between the 2 countries, implying that the proportion of cases effectively isolated in both countries followed a similar time course as the model.
Mentions: Fourth, the model predicted that when the tipping point was reached, transmission would decline rapidly. This prediction was shown to be accurate in the following months in Liberia and Sierra Leone (Figure 3). For Liberia, the model’s prediction that if urgent action were taken, there would be 10,000–27,000 cumulative cases by January 21, 2015, closely matched the 8,500–24,000 cases that occurred (Figure 4). The predictions also closely matched the actual case trajectory after effective intervention.

Bottom Line: Since Ebola virus disease was identified in West Africa on March 23, 2014, the Centers for Disease Control and Prevention (CDC) has undertaken the most intensive response in the agency's history; >3,000 staff have been involved, including >1,200 deployed to West Africa for >50,000 person workdays.All efforts were undertaken as part of national and global response activities with many partner organizations.CDC was able to support community, national, and international health and public health staff to prevent an even worse event.

View Article: PubMed Central - PubMed

ABSTRACT
Since Ebola virus disease was identified in West Africa on March 23, 2014, the Centers for Disease Control and Prevention (CDC) has undertaken the most intensive response in the agency's history; >3,000 staff have been involved, including >1,200 deployed to West Africa for >50,000 person workdays. Efforts have included supporting incident management systems in affected countries; mobilizing partners; and strengthening laboratory, epidemiology, contact investigation, health care infection control, communication, and border screening in West Africa, Nigeria, Mali, Senegal, and the United States. All efforts were undertaken as part of national and global response activities with many partner organizations. CDC was able to support community, national, and international health and public health staff to prevent an even worse event. The Ebola virus disease epidemic highlights the need to strengthen national and international systems to detect, respond to, and prevent the spread of future health threats.

No MeSH data available.


Related in: MedlinePlus