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Substance P and Chronic Pain in Patients with Chronic Inflammation of Connective Tissue.

Lisowska B, Lisowski A, Siewruk K - PLoS ONE (2015)

Bottom Line: The results showed a positive correlation between the serum SP concentrations and chronic pain intensity. 1.The SP serum concentration was significantly different between the groups of patients with OA and RA. 2.There was a positive correlation between the serum SP concentration and chronic pain intensity in OA and RA patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Anaesthesiology, Medical Centre for Postgraduate Education, Adam Gruca Clinical Hospital, Postgraduate Medical Education Centre, Otwock, Poland.

ABSTRACT

Objective: Evidence suggests that substance P (SP) is involved in chronic joint inflammation, such as the pathogenesis of rheumatoid arthritis and osteoarthritis. The goal of the research was to evaluate the correlation between chronic pain and changes in the SP level in patients with chronic inflammation of the connective tissue.

Methods: Patients with osteoarthritis and rheumatoid arthritis were enrolled in this study. The relationship between chronic pain intensity and the serum SP concentration was evaluated in these groups of patients with osteoarthritis and rheumatoid arthritis.

Results: The results showed a positive correlation between the serum SP concentrations and chronic pain intensity.

Conclusions: 1. The SP serum concentration was significantly different between the groups of patients with OA and RA. 2. There was a positive correlation between the serum SP concentration and chronic pain intensity in OA and RA patients.

No MeSH data available.


Related in: MedlinePlus

The relationship between NPS and the serum concentration of substance P (SP) for OA patients.
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pone.0139206.g001: The relationship between NPS and the serum concentration of substance P (SP) for OA patients.

Mentions: Based on a correlation analysis and positional relationship between the SP and NPS points, a logarithmic function was found only for the OA group patients (Fig 1). The value of the determination coefficient indicates that 63.97% of the SP concentration alters the perceived chronic pain according to NPS. In the range of low concentrations of P, up to 200 pg/ml, there was a dynamic increase in the value of perceived pain NPS, in the range of 2 to 3 points.


Substance P and Chronic Pain in Patients with Chronic Inflammation of Connective Tissue.

Lisowska B, Lisowski A, Siewruk K - PLoS ONE (2015)

The relationship between NPS and the serum concentration of substance P (SP) for OA patients.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4622041&req=5

pone.0139206.g001: The relationship between NPS and the serum concentration of substance P (SP) for OA patients.
Mentions: Based on a correlation analysis and positional relationship between the SP and NPS points, a logarithmic function was found only for the OA group patients (Fig 1). The value of the determination coefficient indicates that 63.97% of the SP concentration alters the perceived chronic pain according to NPS. In the range of low concentrations of P, up to 200 pg/ml, there was a dynamic increase in the value of perceived pain NPS, in the range of 2 to 3 points.

Bottom Line: The results showed a positive correlation between the serum SP concentrations and chronic pain intensity. 1.The SP serum concentration was significantly different between the groups of patients with OA and RA. 2.There was a positive correlation between the serum SP concentration and chronic pain intensity in OA and RA patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Anaesthesiology, Medical Centre for Postgraduate Education, Adam Gruca Clinical Hospital, Postgraduate Medical Education Centre, Otwock, Poland.

ABSTRACT

Objective: Evidence suggests that substance P (SP) is involved in chronic joint inflammation, such as the pathogenesis of rheumatoid arthritis and osteoarthritis. The goal of the research was to evaluate the correlation between chronic pain and changes in the SP level in patients with chronic inflammation of the connective tissue.

Methods: Patients with osteoarthritis and rheumatoid arthritis were enrolled in this study. The relationship between chronic pain intensity and the serum SP concentration was evaluated in these groups of patients with osteoarthritis and rheumatoid arthritis.

Results: The results showed a positive correlation between the serum SP concentrations and chronic pain intensity.

Conclusions: 1. The SP serum concentration was significantly different between the groups of patients with OA and RA. 2. There was a positive correlation between the serum SP concentration and chronic pain intensity in OA and RA patients.

No MeSH data available.


Related in: MedlinePlus