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Effects on gastric mucosa induced by dental bleaching - an experimental study with 6% hydrogen peroxide in rats.

Paula AB, Dias MI, Ferreira MM, Carrilho T, Marto CM, Casalta J, Cabrita AS, Carrilho E - J Appl Oral Sci (2015)

Bottom Line: There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups.Changes in spleen weight relative to body weight revealed no statistically significant changes.An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa.Results The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV.

View Article: PubMed Central - PubMed

Affiliation: Escola de Medicina, Universidade de Coimbra, Coimbra, Portugal.

ABSTRACT
The value of aesthetic dentistry has precipitated several developments in the investigation of dental materials related to this field. The free marketing of these products is a problem and it is subject to various interpretations regarding its legality. There are several techniques for tooth whitening, the most used one being the external bleaching. It is the later version of such technique that poses the greatest danger of ingesting the product. The present study analysed the systemic effect of these products when they are swallowed.Objective This experimental study aimed to observe the effects of a tooth whitening product, whose active agent is 6% hydrogen peroxide, on the gastric mucosa of healthy and non-tumour gastric pathology animals.Material and Methods Fifty Wistar-Han rats were used and then distributed into 5 groups, one for control and four test groups in which the bleaching product was administered in animals with and without non-tumour gastric pathology (induced by the administration of 1 sample of 50% ethanol and 5% of drinking water during 6 days) at different times of study by gavage. There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups. Changes in spleen weight relative to body weight revealed no statistically significant changes. An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa.Results The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV. It appears that there is a synergism when using hydrogen peroxide and 50% ethanol in the same group.Conclusion Therefore, it seems that there are some signs of toxicity 3 to 4 days after administration of 6% hydrogen peroxide. The prescription of these therapies must be controlled by the clinician and the risks must be minimized.

No MeSH data available.


Related in: MedlinePlus

Macroscopic observation of the gastric mucosa in relation to parameter - Erasing of the mucosa folds
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f08: Macroscopic observation of the gastric mucosa in relation to parameter - Erasing of the mucosa folds

Mentions: The erasing of the folds of the mucosa parameter does not show a generalized pattern, because a large percentage of animals of various manipulated groups have frequency zero of this parameter. Only in groups IIA, IV, and VA this feature is scored as the ones with most occurrence. However, in groups III, IV and VA, this parameter presents higher frequency (Figure 8).


Effects on gastric mucosa induced by dental bleaching - an experimental study with 6% hydrogen peroxide in rats.

Paula AB, Dias MI, Ferreira MM, Carrilho T, Marto CM, Casalta J, Cabrita AS, Carrilho E - J Appl Oral Sci (2015)

Macroscopic observation of the gastric mucosa in relation to parameter - Erasing of the mucosa folds
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4621943&req=5

f08: Macroscopic observation of the gastric mucosa in relation to parameter - Erasing of the mucosa folds
Mentions: The erasing of the folds of the mucosa parameter does not show a generalized pattern, because a large percentage of animals of various manipulated groups have frequency zero of this parameter. Only in groups IIA, IV, and VA this feature is scored as the ones with most occurrence. However, in groups III, IV and VA, this parameter presents higher frequency (Figure 8).

Bottom Line: There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups.Changes in spleen weight relative to body weight revealed no statistically significant changes.An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa.Results The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV.

View Article: PubMed Central - PubMed

Affiliation: Escola de Medicina, Universidade de Coimbra, Coimbra, Portugal.

ABSTRACT
The value of aesthetic dentistry has precipitated several developments in the investigation of dental materials related to this field. The free marketing of these products is a problem and it is subject to various interpretations regarding its legality. There are several techniques for tooth whitening, the most used one being the external bleaching. It is the later version of such technique that poses the greatest danger of ingesting the product. The present study analysed the systemic effect of these products when they are swallowed.Objective This experimental study aimed to observe the effects of a tooth whitening product, whose active agent is 6% hydrogen peroxide, on the gastric mucosa of healthy and non-tumour gastric pathology animals.Material and Methods Fifty Wistar-Han rats were used and then distributed into 5 groups, one for control and four test groups in which the bleaching product was administered in animals with and without non-tumour gastric pathology (induced by the administration of 1 sample of 50% ethanol and 5% of drinking water during 6 days) at different times of study by gavage. There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups. Changes in spleen weight relative to body weight revealed no statistically significant changes. An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa.Results The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV. It appears that there is a synergism when using hydrogen peroxide and 50% ethanol in the same group.Conclusion Therefore, it seems that there are some signs of toxicity 3 to 4 days after administration of 6% hydrogen peroxide. The prescription of these therapies must be controlled by the clinician and the risks must be minimized.

No MeSH data available.


Related in: MedlinePlus