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Effects on gastric mucosa induced by dental bleaching - an experimental study with 6% hydrogen peroxide in rats.

Paula AB, Dias MI, Ferreira MM, Carrilho T, Marto CM, Casalta J, Cabrita AS, Carrilho E - J Appl Oral Sci (2015)

Bottom Line: There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups.Changes in spleen weight relative to body weight revealed no statistically significant changes.An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa.Results The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV.

View Article: PubMed Central - PubMed

Affiliation: Escola de Medicina, Universidade de Coimbra, Coimbra, Portugal.

ABSTRACT
The value of aesthetic dentistry has precipitated several developments in the investigation of dental materials related to this field. The free marketing of these products is a problem and it is subject to various interpretations regarding its legality. There are several techniques for tooth whitening, the most used one being the external bleaching. It is the later version of such technique that poses the greatest danger of ingesting the product. The present study analysed the systemic effect of these products when they are swallowed.Objective This experimental study aimed to observe the effects of a tooth whitening product, whose active agent is 6% hydrogen peroxide, on the gastric mucosa of healthy and non-tumour gastric pathology animals.Material and Methods Fifty Wistar-Han rats were used and then distributed into 5 groups, one for control and four test groups in which the bleaching product was administered in animals with and without non-tumour gastric pathology (induced by the administration of 1 sample of 50% ethanol and 5% of drinking water during 6 days) at different times of study by gavage. There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups. Changes in spleen weight relative to body weight revealed no statistically significant changes. An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa.Results The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV. It appears that there is a synergism when using hydrogen peroxide and 50% ethanol in the same group.Conclusion Therefore, it seems that there are some signs of toxicity 3 to 4 days after administration of 6% hydrogen peroxide. The prescription of these therapies must be controlled by the clinician and the risks must be minimized.

No MeSH data available.


Related in: MedlinePlus

Macroscopic observation of the gastric mucosa in relation to parameter - Macroscopically corresponding to inflammation areas
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f07: Macroscopic observation of the gastric mucosa in relation to parameter - Macroscopically corresponding to inflammation areas

Mentions: For the analysis of Figure 7, we can observe that all manipulated groups have macroscopic areas corresponding to inflammation, which is more pronounced in groups II, IV, and VA. In group III, despite the fact that the highest frequency values corresponding to macroscopically inflammation areas are not present, over 50% of the animals of this group present high frequency values for this parameter. In group IV, both situations occur, presenting the highest frequency values and greater percentage of animals with gastric inflammation. The control group did not show any animals with macroscopic inflammation areas.


Effects on gastric mucosa induced by dental bleaching - an experimental study with 6% hydrogen peroxide in rats.

Paula AB, Dias MI, Ferreira MM, Carrilho T, Marto CM, Casalta J, Cabrita AS, Carrilho E - J Appl Oral Sci (2015)

Macroscopic observation of the gastric mucosa in relation to parameter - Macroscopically corresponding to inflammation areas
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4621943&req=5

f07: Macroscopic observation of the gastric mucosa in relation to parameter - Macroscopically corresponding to inflammation areas
Mentions: For the analysis of Figure 7, we can observe that all manipulated groups have macroscopic areas corresponding to inflammation, which is more pronounced in groups II, IV, and VA. In group III, despite the fact that the highest frequency values corresponding to macroscopically inflammation areas are not present, over 50% of the animals of this group present high frequency values for this parameter. In group IV, both situations occur, presenting the highest frequency values and greater percentage of animals with gastric inflammation. The control group did not show any animals with macroscopic inflammation areas.

Bottom Line: There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups.Changes in spleen weight relative to body weight revealed no statistically significant changes.An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa.Results The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV.

View Article: PubMed Central - PubMed

Affiliation: Escola de Medicina, Universidade de Coimbra, Coimbra, Portugal.

ABSTRACT
The value of aesthetic dentistry has precipitated several developments in the investigation of dental materials related to this field. The free marketing of these products is a problem and it is subject to various interpretations regarding its legality. There are several techniques for tooth whitening, the most used one being the external bleaching. It is the later version of such technique that poses the greatest danger of ingesting the product. The present study analysed the systemic effect of these products when they are swallowed.Objective This experimental study aimed to observe the effects of a tooth whitening product, whose active agent is 6% hydrogen peroxide, on the gastric mucosa of healthy and non-tumour gastric pathology animals.Material and Methods Fifty Wistar-Han rats were used and then distributed into 5 groups, one for control and four test groups in which the bleaching product was administered in animals with and without non-tumour gastric pathology (induced by the administration of 1 sample of 50% ethanol and 5% of drinking water during 6 days) at different times of study by gavage. There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups. Changes in spleen weight relative to body weight revealed no statistically significant changes. An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa.Results The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV. It appears that there is a synergism when using hydrogen peroxide and 50% ethanol in the same group.Conclusion Therefore, it seems that there are some signs of toxicity 3 to 4 days after administration of 6% hydrogen peroxide. The prescription of these therapies must be controlled by the clinician and the risks must be minimized.

No MeSH data available.


Related in: MedlinePlus