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Progression of carotid-artery disease in type 2 diabetic patients: a cohort prospective study.

Bosevski M, Stojanovska L - Vasc Health Risk Manag (2015)

Bottom Line: The maximal value of CIMT changed by 0.07 mm/year.The occurrence of carotid plaques was detected in 41.8% of patients.The presence of peripheral arterial disease and hypo-high-density lipoproteinemia were found to be predictors for the occurrence of carotid plaques.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine, University Cardiology Clinic, Skopje, Macedonia.

ABSTRACT
In order to assess the progression of carotid-artery disease in type 2 diabetic cohort (n=207 patients), the dynamic change in carotid intima-media thickness (CIMT) and the occurrence of plaques were followed for a period of 31.35±10.59 months. The mean CIMT at the beginning of the study was 0.9178±0.1447 mm, with a maximal value of 1.1210±0.2366 mm. The maximal value of CIMT changed by 0.07 mm/year. Progression of CIMT was noted in 86.8% and its regression in 7.8% of patients. The occurrence of carotid plaques was detected in 41.8% of patients. Multiple regression analysis revealed the maximal value of CIMT to be associated with diastolic blood pressure, despite mean CIMT being predicted by body mass index. The presence of peripheral arterial disease and hypo-high-density lipoproteinemia were found to be predictors for the occurrence of carotid plaques. Our data have clinical implications in predicting risk factors for the progression of carotid-artery disease in type 2 diabetic patients for their appropriate management.

No MeSH data available.


Related in: MedlinePlus

Relationship of glycemia to CIMT.Abbreviations: CIMT, carotid intima-media thickness; GI, glycemia.
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f1-vhrm-11-549: Relationship of glycemia to CIMT.Abbreviations: CIMT, carotid intima-media thickness; GI, glycemia.

Mentions: Since postprandial glycemia was included in the multiple linear regression analysis in the progression of CAD, the same value was shown as a substantive value compared to degree of carotid stenosis. Raised amounts of glycated hemoglobin (HbA1c) >7% were in linear correlation with maximal change in CIMT (Figure 1).


Progression of carotid-artery disease in type 2 diabetic patients: a cohort prospective study.

Bosevski M, Stojanovska L - Vasc Health Risk Manag (2015)

Relationship of glycemia to CIMT.Abbreviations: CIMT, carotid intima-media thickness; GI, glycemia.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4621201&req=5

f1-vhrm-11-549: Relationship of glycemia to CIMT.Abbreviations: CIMT, carotid intima-media thickness; GI, glycemia.
Mentions: Since postprandial glycemia was included in the multiple linear regression analysis in the progression of CAD, the same value was shown as a substantive value compared to degree of carotid stenosis. Raised amounts of glycated hemoglobin (HbA1c) >7% were in linear correlation with maximal change in CIMT (Figure 1).

Bottom Line: The maximal value of CIMT changed by 0.07 mm/year.The occurrence of carotid plaques was detected in 41.8% of patients.The presence of peripheral arterial disease and hypo-high-density lipoproteinemia were found to be predictors for the occurrence of carotid plaques.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Medicine, University Cardiology Clinic, Skopje, Macedonia.

ABSTRACT
In order to assess the progression of carotid-artery disease in type 2 diabetic cohort (n=207 patients), the dynamic change in carotid intima-media thickness (CIMT) and the occurrence of plaques were followed for a period of 31.35±10.59 months. The mean CIMT at the beginning of the study was 0.9178±0.1447 mm, with a maximal value of 1.1210±0.2366 mm. The maximal value of CIMT changed by 0.07 mm/year. Progression of CIMT was noted in 86.8% and its regression in 7.8% of patients. The occurrence of carotid plaques was detected in 41.8% of patients. Multiple regression analysis revealed the maximal value of CIMT to be associated with diastolic blood pressure, despite mean CIMT being predicted by body mass index. The presence of peripheral arterial disease and hypo-high-density lipoproteinemia were found to be predictors for the occurrence of carotid plaques. Our data have clinical implications in predicting risk factors for the progression of carotid-artery disease in type 2 diabetic patients for their appropriate management.

No MeSH data available.


Related in: MedlinePlus