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Selective vulnerability of Rich Club brain regions is an organizational principle of structural connectivity loss in Huntington's disease.

McColgan P, Seunarine KK, Razi A, Cole JH, Gregory S, Durr A, Roos RA, Stout JC, Landwehrmeyer B, Scahill RI, Clark CA, Rees G, Tabrizi SJ, Track-HD Investigato - Brain (2015)

Bottom Line: By understanding such principles we can gain insight into the link between the cellular pathology caused by mutant huntingtin and its downstream effect at the macroscopic level.We also observed greater reductions in the connectivity of brain regions that have higher network traffic and lower clustering of neighbouring regions.This provides a potential mechanism that results in a characteristic pattern of structural connectivity loss targeting highly connected brain regions with high network traffic and low clustering of neighbouring regions.

View Article: PubMed Central - PubMed

Affiliation: 1 Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG, UK s.tabrizi@ucl.ac.uk g.rees@ucl.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Diffuse structural connectivity loss occurs early in Huntington’s disease. However, the organizational principles underlying these changes are unclear. Using whole brain diffusion tractography and graph theoretical analysis, McColgan, Seunarine et al. identify a specific role for highly connected rich club regions as a substrate for structural connectivity loss in Huntington’s disease.
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fig1g: Diffuse structural connectivity loss occurs early in Huntington’s disease. However, the organizational principles underlying these changes are unclear. Using whole brain diffusion tractography and graph theoretical analysis, McColgan, Seunarine et al. identify a specific role for highly connected rich club regions as a substrate for structural connectivity loss in Huntington’s disease.


Selective vulnerability of Rich Club brain regions is an organizational principle of structural connectivity loss in Huntington's disease.

McColgan P, Seunarine KK, Razi A, Cole JH, Gregory S, Durr A, Roos RA, Stout JC, Landwehrmeyer B, Scahill RI, Clark CA, Rees G, Tabrizi SJ, Track-HD Investigato - Brain (2015)

Diffuse structural connectivity loss occurs early in Huntington’s disease. However, the organizational principles underlying these changes are unclear. Using whole brain diffusion tractography and graph theoretical analysis, McColgan, Seunarine et al. identify a specific role for highly connected rich club regions as a substrate for structural connectivity loss in Huntington’s disease.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4620513&req=5

fig1g: Diffuse structural connectivity loss occurs early in Huntington’s disease. However, the organizational principles underlying these changes are unclear. Using whole brain diffusion tractography and graph theoretical analysis, McColgan, Seunarine et al. identify a specific role for highly connected rich club regions as a substrate for structural connectivity loss in Huntington’s disease.
Bottom Line: By understanding such principles we can gain insight into the link between the cellular pathology caused by mutant huntingtin and its downstream effect at the macroscopic level.We also observed greater reductions in the connectivity of brain regions that have higher network traffic and lower clustering of neighbouring regions.This provides a potential mechanism that results in a characteristic pattern of structural connectivity loss targeting highly connected brain regions with high network traffic and low clustering of neighbouring regions.

View Article: PubMed Central - PubMed

Affiliation: 1 Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG, UK s.tabrizi@ucl.ac.uk g.rees@ucl.ac.uk.

No MeSH data available.


Related in: MedlinePlus