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Cortical metabolic arrangement during olfactory processing: proposal for a 18F FDG PET/CT methodological approach.

Micarelli A, Pagani M, Chiaravalloti A, Bruno E, Pavone I, Candidi M, Danieli R, Schillaci O, Alessandrini M - Medicine (Baltimore) (2014)

Bottom Line: All the subjects were injected with 185-210 megabecquerel of F FDG during both stimulations.Statistical parametric mapping version 2 was used in order to assess differences between NC and OC.As a result, we found a significant higher glucose consumption during OC in the cuneus, lingual, and parahippocampal gyri, mainly in the left hemisphere.During NC, our results show a relative higher glucose metabolism in the left superior, inferior, middle, medial frontal, and orbital gyri as well as in the anterior cingulate cortex.The present investigation, performed with a widely available functional imaging clinical tool, may help to better understand the neural responses associated to olfactory processing in healthy individuals and in patients with olfactory disorders by acquiring data in an ecologic, noise-free, and resting condition in which possible cerebral activations related to unwanted attentional processes might be avoided.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Sciences and Translational Medicine (AM, EB, IP, MA), Tor Vergata University; Institute of Cognitive Sciences and Technologies-CNR (MP), Rome, Italy; Department of Nuclear Medicine (MP), Karolinska University Hospital, Stockholm, Sweden; Department of Biomedicine and Prevention (AC, RD, OS), Tor Vergata University; Department of Psychology (MC), "Sapienza" University, Rome; and IRCCS Neuromed (OS), Pozzilli, Italy.

ABSTRACT
The aim of this article is to investigate the cortical metabolic arrangements in olfactory processing by using F fluorodeoxyglucose (FDG) positron emission tomography/computed tomography.Twenty-six normosmic individuals (14 women and 12 men; mean age 46.7 ± 10 years) were exposed to a neutral olfactory condition (NC) and, after 1 month, to a pure olfactory condition (OC) in a relatively ecological environment, that is, outside the scanner. All the subjects were injected with 185-210 megabecquerel of F FDG during both stimulations. Statistical parametric mapping version 2 was used in order to assess differences between NC and OC.As a result, we found a significant higher glucose consumption during OC in the cuneus, lingual, and parahippocampal gyri, mainly in the left hemisphere. During NC, our results show a relative higher glucose metabolism in the left superior, inferior, middle, medial frontal, and orbital gyri as well as in the anterior cingulate cortex.The present investigation, performed with a widely available functional imaging clinical tool, may help to better understand the neural responses associated to olfactory processing in healthy individuals and in patients with olfactory disorders by acquiring data in an ecologic, noise-free, and resting condition in which possible cerebral activations related to unwanted attentional processes might be avoided.

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Related in: MedlinePlus

T1 MRI superimposition showing the cluster of voxels in the cuneus, lingual gyrus, and parahippocampal gyrus, mainly in the left hemisphere, in which FDG uptake was significantly higher at OC (n = 26) as compared to NC (n = 26) (on the left sagittal and on the right coronal projections). Coordinates and regional details are presented in Table 1. FDG = 18F fluorodeoxyglucose, MRI = magnetic resonance imaging, NC = neutral olfactory condition, OC = pure olfactory condition.
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Figure 1: T1 MRI superimposition showing the cluster of voxels in the cuneus, lingual gyrus, and parahippocampal gyrus, mainly in the left hemisphere, in which FDG uptake was significantly higher at OC (n = 26) as compared to NC (n = 26) (on the left sagittal and on the right coronal projections). Coordinates and regional details are presented in Table 1. FDG = 18F fluorodeoxyglucose, MRI = magnetic resonance imaging, NC = neutral olfactory condition, OC = pure olfactory condition.

Mentions: A significantly higher glucose metabolism was found in OC compared to NC in cuneus (CU), lingual gyrus (LG), and parahippocampal gyrus (PHG), mainly in the left hemisphere (Table 1, Figure 1). In the opposite comparison (NC compared to OC), a relative higher glucose metabolism was found in left superior, inferior, middle, medial frontal, and orbital gyrus (orbitofrontal cortex [OFC]) as well as in anterior cingulate cortex (ACC) (Table 2, Figure 2).


Cortical metabolic arrangement during olfactory processing: proposal for a 18F FDG PET/CT methodological approach.

Micarelli A, Pagani M, Chiaravalloti A, Bruno E, Pavone I, Candidi M, Danieli R, Schillaci O, Alessandrini M - Medicine (Baltimore) (2014)

T1 MRI superimposition showing the cluster of voxels in the cuneus, lingual gyrus, and parahippocampal gyrus, mainly in the left hemisphere, in which FDG uptake was significantly higher at OC (n = 26) as compared to NC (n = 26) (on the left sagittal and on the right coronal projections). Coordinates and regional details are presented in Table 1. FDG = 18F fluorodeoxyglucose, MRI = magnetic resonance imaging, NC = neutral olfactory condition, OC = pure olfactory condition.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4616321&req=5

Figure 1: T1 MRI superimposition showing the cluster of voxels in the cuneus, lingual gyrus, and parahippocampal gyrus, mainly in the left hemisphere, in which FDG uptake was significantly higher at OC (n = 26) as compared to NC (n = 26) (on the left sagittal and on the right coronal projections). Coordinates and regional details are presented in Table 1. FDG = 18F fluorodeoxyglucose, MRI = magnetic resonance imaging, NC = neutral olfactory condition, OC = pure olfactory condition.
Mentions: A significantly higher glucose metabolism was found in OC compared to NC in cuneus (CU), lingual gyrus (LG), and parahippocampal gyrus (PHG), mainly in the left hemisphere (Table 1, Figure 1). In the opposite comparison (NC compared to OC), a relative higher glucose metabolism was found in left superior, inferior, middle, medial frontal, and orbital gyrus (orbitofrontal cortex [OFC]) as well as in anterior cingulate cortex (ACC) (Table 2, Figure 2).

Bottom Line: All the subjects were injected with 185-210 megabecquerel of F FDG during both stimulations.Statistical parametric mapping version 2 was used in order to assess differences between NC and OC.As a result, we found a significant higher glucose consumption during OC in the cuneus, lingual, and parahippocampal gyri, mainly in the left hemisphere.During NC, our results show a relative higher glucose metabolism in the left superior, inferior, middle, medial frontal, and orbital gyri as well as in the anterior cingulate cortex.The present investigation, performed with a widely available functional imaging clinical tool, may help to better understand the neural responses associated to olfactory processing in healthy individuals and in patients with olfactory disorders by acquiring data in an ecologic, noise-free, and resting condition in which possible cerebral activations related to unwanted attentional processes might be avoided.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Sciences and Translational Medicine (AM, EB, IP, MA), Tor Vergata University; Institute of Cognitive Sciences and Technologies-CNR (MP), Rome, Italy; Department of Nuclear Medicine (MP), Karolinska University Hospital, Stockholm, Sweden; Department of Biomedicine and Prevention (AC, RD, OS), Tor Vergata University; Department of Psychology (MC), "Sapienza" University, Rome; and IRCCS Neuromed (OS), Pozzilli, Italy.

ABSTRACT
The aim of this article is to investigate the cortical metabolic arrangements in olfactory processing by using F fluorodeoxyglucose (FDG) positron emission tomography/computed tomography.Twenty-six normosmic individuals (14 women and 12 men; mean age 46.7 ± 10 years) were exposed to a neutral olfactory condition (NC) and, after 1 month, to a pure olfactory condition (OC) in a relatively ecological environment, that is, outside the scanner. All the subjects were injected with 185-210 megabecquerel of F FDG during both stimulations. Statistical parametric mapping version 2 was used in order to assess differences between NC and OC.As a result, we found a significant higher glucose consumption during OC in the cuneus, lingual, and parahippocampal gyri, mainly in the left hemisphere. During NC, our results show a relative higher glucose metabolism in the left superior, inferior, middle, medial frontal, and orbital gyri as well as in the anterior cingulate cortex.The present investigation, performed with a widely available functional imaging clinical tool, may help to better understand the neural responses associated to olfactory processing in healthy individuals and in patients with olfactory disorders by acquiring data in an ecologic, noise-free, and resting condition in which possible cerebral activations related to unwanted attentional processes might be avoided.

Show MeSH
Related in: MedlinePlus