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L-carnitine reduces acute lung injury in experimental biliary obstruction.

Kaya O, Koca YS, Barut İ, Baspinar S, Sabuncuoglu MZ - Saudi Med J (2015)

Bottom Line: Enzyme levels were measured in the lung tissue; malondialdehyde, myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), catalase, and superoxide dismutase.Histopathological changes in the lungs were examined.  There was a decreased in GSH-Px, MPO, and IL-8 levels (p less than 0.05) in the LCT group.The histopathological examination showed that neutrophil leukocyte infiltration and edema formation decreased and destruction of lung parenchyma disappeared following the treatment with LC (p less than 0.05).  L-carnitine has a protective effect against lung damage due to experimental obstructive jaundice, possibly by altering anticytokine and antioxidant activity, and by decreasing the neutrophil migration.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Medical Doctor of Yenimahalle State Hospital, Ankara, Turkey. E-mail. ozgur@yahoo.com.

ABSTRACT

Objectives: To investigate the protective effects of L-carnitine (LC) on lungs in an experimental obstructive jaundice (OJ) model.

Methods: This was conducted for 2 months between May 2011 and July 2011 at Suleyman Demirel University School of Medicine Experimental and Clinical Research Center, Isparta, Turkey. Thirty-eight Wistar-Albino rats with an average weight of 250-300 g were divided into 3 groups of control, OJ, and OJ + L-carnitine treatment (LCT). L-carnitine was injected intravenously into the tail vein at a dose of 50 mg/kg/day for 10 days to the LCT group. Animals were sacrificed 10 days later. Enzyme levels were measured in the lung tissue; malondialdehyde, myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), catalase, and superoxide dismutase. Tumor necrosis factor-alfa, interleukin 6 (IL-6), IL-8, and C-reactive protein levels were studied in plasma samples. Histopathological changes in the lungs were examined. 

Results: There was a decreased in GSH-Px, MPO, and IL-8 levels (p less than 0.05) in the LCT group. The histopathological examination showed that neutrophil leukocyte infiltration and edema formation decreased and destruction of lung parenchyma disappeared following the treatment with LC (p less than 0.05). 

Conclusion: L-carnitine has a protective effect against lung damage due to experimental obstructive jaundice, possibly by altering anticytokine and antioxidant activity, and by decreasing the neutrophil migration.

No MeSH data available.


Related in: MedlinePlus

Distribution of serum IL-8 levels among groups. OJ - obstructive jaundice, LCG - L-carnitine group
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Figure 1: Distribution of serum IL-8 levels among groups. OJ - obstructive jaundice, LCG - L-carnitine group

Mentions: The IL-8 levels in the OJ group were significantly elevated in comparison with those in the control and LC groups (p<0.05, Figure 1).


L-carnitine reduces acute lung injury in experimental biliary obstruction.

Kaya O, Koca YS, Barut İ, Baspinar S, Sabuncuoglu MZ - Saudi Med J (2015)

Distribution of serum IL-8 levels among groups. OJ - obstructive jaundice, LCG - L-carnitine group
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4613627&req=5

Figure 1: Distribution of serum IL-8 levels among groups. OJ - obstructive jaundice, LCG - L-carnitine group
Mentions: The IL-8 levels in the OJ group were significantly elevated in comparison with those in the control and LC groups (p<0.05, Figure 1).

Bottom Line: Enzyme levels were measured in the lung tissue; malondialdehyde, myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), catalase, and superoxide dismutase.Histopathological changes in the lungs were examined.  There was a decreased in GSH-Px, MPO, and IL-8 levels (p less than 0.05) in the LCT group.The histopathological examination showed that neutrophil leukocyte infiltration and edema formation decreased and destruction of lung parenchyma disappeared following the treatment with LC (p less than 0.05).  L-carnitine has a protective effect against lung damage due to experimental obstructive jaundice, possibly by altering anticytokine and antioxidant activity, and by decreasing the neutrophil migration.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Medical Doctor of Yenimahalle State Hospital, Ankara, Turkey. E-mail. ozgur@yahoo.com.

ABSTRACT

Objectives: To investigate the protective effects of L-carnitine (LC) on lungs in an experimental obstructive jaundice (OJ) model.

Methods: This was conducted for 2 months between May 2011 and July 2011 at Suleyman Demirel University School of Medicine Experimental and Clinical Research Center, Isparta, Turkey. Thirty-eight Wistar-Albino rats with an average weight of 250-300 g were divided into 3 groups of control, OJ, and OJ + L-carnitine treatment (LCT). L-carnitine was injected intravenously into the tail vein at a dose of 50 mg/kg/day for 10 days to the LCT group. Animals were sacrificed 10 days later. Enzyme levels were measured in the lung tissue; malondialdehyde, myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), catalase, and superoxide dismutase. Tumor necrosis factor-alfa, interleukin 6 (IL-6), IL-8, and C-reactive protein levels were studied in plasma samples. Histopathological changes in the lungs were examined. 

Results: There was a decreased in GSH-Px, MPO, and IL-8 levels (p less than 0.05) in the LCT group. The histopathological examination showed that neutrophil leukocyte infiltration and edema formation decreased and destruction of lung parenchyma disappeared following the treatment with LC (p less than 0.05). 

Conclusion: L-carnitine has a protective effect against lung damage due to experimental obstructive jaundice, possibly by altering anticytokine and antioxidant activity, and by decreasing the neutrophil migration.

No MeSH data available.


Related in: MedlinePlus