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Preparation and Characterization of Lanthanum-Incorporated Hydroxyapatite Coatings on Titanium Substrates.

Lou W, Dong Y, Zhang H, Jin Y, Hu X, Ma J, Liu J, Wu G - Int J Mol Sci (2015)

Bottom Line: The XRD, FTIR and EDX results presented in this paper confirmed that lanthanum was successfully incorporated into the structure of HA.The results of the interfacial shear strength test indicated that the incorporation of lanthanum increased the bonding strength of the HA coating.The mass loss ratios under acidic conditions (pH=5.5) suggested that the La-HA coatings have better acid resistance.

View Article: PubMed Central - PubMed

Affiliation: School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China. louweiwei1125@163.com.

ABSTRACT
Titanium (Ti) has been widely used in clinical applications for its excellent biocompatibility and mechanical properties. However, the bioinertness of the surface of Ti has motivated researchers to improve the physicochemical and biological properties of the implants through various surface modifications, such as coatings. For this purpose, we prepared a novel bioactive material, a lanthanum-incorporated hydroxyapatite (La-HA) coating, using a dip-coating technique with a La-HA sol along with post-heat treatment. The XRD, FTIR and EDX results presented in this paper confirmed that lanthanum was successfully incorporated into the structure of HA. The La-HA coating was composed of rod-like particles which densely compacted together without microcracks. The results of the interfacial shear strength test indicated that the incorporation of lanthanum increased the bonding strength of the HA coating. The mass loss ratios under acidic conditions (pH=5.5) suggested that the La-HA coatings have better acid resistance. The cytocompatibility of the La-HA coating was also revealed by the relative activity of alkaline phosphatase, cellular morphology and cell proliferation assay in vitro. The present study suggested that La-HA coated on Ti has promising potential for applications in the development of a new type of bioactive coating for metal implants.

No MeSH data available.


Related in: MedlinePlus

Bonding strengths of coatings on Ti substrates sintered at 600 °C. All data are presented as the mean values together with the standard deviation. *: p < 0.05.
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ijms-16-21070-f006: Bonding strengths of coatings on Ti substrates sintered at 600 °C. All data are presented as the mean values together with the standard deviation. *: p < 0.05.

Mentions: Figure 6 shows the bonding strengths of HA and La-HA coatings sintered at 600 °C. The bonding strengths for HA, 10% La-HA, 20% La-HA and 30% La-HA coatings were 22.9 ± 0.7, 22.2 ± 1.0, 24.0 ± 0.8 and 24.7 ± 1.0 MPa, respectively, which were higher than those in previous studies for electrophoretic and sol-gel HA coatings (7~27 MPa) [30,31,32,33]. The La-HA coatings achieved slightly higher mean values at La contents of 20% and 30% compared that for the pure HA coating. In contrast to the pure HA coating, the values for the 10% La-HA coating decreased, but there was no significant difference between them, which indicated that the introduction of La did not decrease the bonding strength of the HA coating. However, there was an obvious significant difference between the 10% and 30% La-HA coatings: the values for the 20% and 30% La-HA coatings were slightly higher than that for the 10% La-HA coating, which revealed that the bonding strength increased as the La content increased. This result may be related to the densely compacted cross-section of the coatings on the Ti substrate with micro-cracks, as shown in Figure 4. The good adhesion strength of the coating with titanium substrate is also crucial for the long-term stability of the implant [34]. Coatings with poor bonding strength may easily detach from the implant, which may trigger diseases and eventually implant loosening [35]. The present results confirmed that the dip-coating technique was successful for depositing La-HA onto titanium substrates with enhanced adhesion strength.


Preparation and Characterization of Lanthanum-Incorporated Hydroxyapatite Coatings on Titanium Substrates.

Lou W, Dong Y, Zhang H, Jin Y, Hu X, Ma J, Liu J, Wu G - Int J Mol Sci (2015)

Bonding strengths of coatings on Ti substrates sintered at 600 °C. All data are presented as the mean values together with the standard deviation. *: p < 0.05.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4613242&req=5

ijms-16-21070-f006: Bonding strengths of coatings on Ti substrates sintered at 600 °C. All data are presented as the mean values together with the standard deviation. *: p < 0.05.
Mentions: Figure 6 shows the bonding strengths of HA and La-HA coatings sintered at 600 °C. The bonding strengths for HA, 10% La-HA, 20% La-HA and 30% La-HA coatings were 22.9 ± 0.7, 22.2 ± 1.0, 24.0 ± 0.8 and 24.7 ± 1.0 MPa, respectively, which were higher than those in previous studies for electrophoretic and sol-gel HA coatings (7~27 MPa) [30,31,32,33]. The La-HA coatings achieved slightly higher mean values at La contents of 20% and 30% compared that for the pure HA coating. In contrast to the pure HA coating, the values for the 10% La-HA coating decreased, but there was no significant difference between them, which indicated that the introduction of La did not decrease the bonding strength of the HA coating. However, there was an obvious significant difference between the 10% and 30% La-HA coatings: the values for the 20% and 30% La-HA coatings were slightly higher than that for the 10% La-HA coating, which revealed that the bonding strength increased as the La content increased. This result may be related to the densely compacted cross-section of the coatings on the Ti substrate with micro-cracks, as shown in Figure 4. The good adhesion strength of the coating with titanium substrate is also crucial for the long-term stability of the implant [34]. Coatings with poor bonding strength may easily detach from the implant, which may trigger diseases and eventually implant loosening [35]. The present results confirmed that the dip-coating technique was successful for depositing La-HA onto titanium substrates with enhanced adhesion strength.

Bottom Line: The XRD, FTIR and EDX results presented in this paper confirmed that lanthanum was successfully incorporated into the structure of HA.The results of the interfacial shear strength test indicated that the incorporation of lanthanum increased the bonding strength of the HA coating.The mass loss ratios under acidic conditions (pH=5.5) suggested that the La-HA coatings have better acid resistance.

View Article: PubMed Central - PubMed

Affiliation: School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China. louweiwei1125@163.com.

ABSTRACT
Titanium (Ti) has been widely used in clinical applications for its excellent biocompatibility and mechanical properties. However, the bioinertness of the surface of Ti has motivated researchers to improve the physicochemical and biological properties of the implants through various surface modifications, such as coatings. For this purpose, we prepared a novel bioactive material, a lanthanum-incorporated hydroxyapatite (La-HA) coating, using a dip-coating technique with a La-HA sol along with post-heat treatment. The XRD, FTIR and EDX results presented in this paper confirmed that lanthanum was successfully incorporated into the structure of HA. The La-HA coating was composed of rod-like particles which densely compacted together without microcracks. The results of the interfacial shear strength test indicated that the incorporation of lanthanum increased the bonding strength of the HA coating. The mass loss ratios under acidic conditions (pH=5.5) suggested that the La-HA coatings have better acid resistance. The cytocompatibility of the La-HA coating was also revealed by the relative activity of alkaline phosphatase, cellular morphology and cell proliferation assay in vitro. The present study suggested that La-HA coated on Ti has promising potential for applications in the development of a new type of bioactive coating for metal implants.

No MeSH data available.


Related in: MedlinePlus