Limits...
Xanthogranulomatous Cholecystitis Mimicking Biliary Tract Cancer.

Mohamad B, Bhatt A, Kumaravel A, Aucejo F, Jang S, Stevens T, Vargo J, Parsi M - ACG Case Rep J (2015)

Bottom Line: Laboratory tests revealed elevated liver enzymes and CA19-9.Imaging showed dilation of both the intra- and extrahepatic bile ducts, narrowing of the bile duct at the junction of the common bile duct and common hepatic duct, and a hypoechoic mass involving the neck of the gallbladder and the muscularis propria of the duodenum.Examination of the resected gallbladder and perihilar nodes ruled out malignancy and revealed a diffuse inflammatory infiltrate of giant histiocytes with clear, lipid-containing cytoplasm (xanthoma cells), consistent with xanthogranulomatous cholecystitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Cleveland Clinic, Cleveland, OH.

ABSTRACT
We present a 42-year-old man with a 1-month history of painless jaundice, dark urine, clay-colored stools, and a 13.5-kg weight loss. Laboratory tests revealed elevated liver enzymes and CA19-9. Imaging showed dilation of both the intra- and extrahepatic bile ducts, narrowing of the bile duct at the junction of the common bile duct and common hepatic duct, and a hypoechoic mass involving the neck of the gallbladder and the muscularis propria of the duodenum. Examination of the resected gallbladder and perihilar nodes ruled out malignancy and revealed a diffuse inflammatory infiltrate of giant histiocytes with clear, lipid-containing cytoplasm (xanthoma cells), consistent with xanthogranulomatous cholecystitis.

No MeSH data available.


Related in: MedlinePlus

Pathologic examination of resected gallbladder showing a diffuse inflammatory infiltrate of giant histiocytes with clear, lipid-containing cytoplasm (xanthoma cells).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4612761&req=5

Figure 3: Pathologic examination of resected gallbladder showing a diffuse inflammatory infiltrate of giant histiocytes with clear, lipid-containing cytoplasm (xanthoma cells).

Mentions: Due to the atypical appearance of the mass and diagnostic uncertainty, an exploratory laparotomy was performed. Intraoperative frozen section of the resected gallbladder and perihilar nodes revealed chronic inflammation and fibrosis without malignancy, and further resection was not performed. Final pathologic evaluation revealed a diffuse inflammatory infiltrate of giant histiocytes with clear, lipid-containing cytoplasm (xanthoma cells) consistent with xanthogranulomatous tumor-like inflammation (Figure 3).


Xanthogranulomatous Cholecystitis Mimicking Biliary Tract Cancer.

Mohamad B, Bhatt A, Kumaravel A, Aucejo F, Jang S, Stevens T, Vargo J, Parsi M - ACG Case Rep J (2015)

Pathologic examination of resected gallbladder showing a diffuse inflammatory infiltrate of giant histiocytes with clear, lipid-containing cytoplasm (xanthoma cells).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4612761&req=5

Figure 3: Pathologic examination of resected gallbladder showing a diffuse inflammatory infiltrate of giant histiocytes with clear, lipid-containing cytoplasm (xanthoma cells).
Mentions: Due to the atypical appearance of the mass and diagnostic uncertainty, an exploratory laparotomy was performed. Intraoperative frozen section of the resected gallbladder and perihilar nodes revealed chronic inflammation and fibrosis without malignancy, and further resection was not performed. Final pathologic evaluation revealed a diffuse inflammatory infiltrate of giant histiocytes with clear, lipid-containing cytoplasm (xanthoma cells) consistent with xanthogranulomatous tumor-like inflammation (Figure 3).

Bottom Line: Laboratory tests revealed elevated liver enzymes and CA19-9.Imaging showed dilation of both the intra- and extrahepatic bile ducts, narrowing of the bile duct at the junction of the common bile duct and common hepatic duct, and a hypoechoic mass involving the neck of the gallbladder and the muscularis propria of the duodenum.Examination of the resected gallbladder and perihilar nodes ruled out malignancy and revealed a diffuse inflammatory infiltrate of giant histiocytes with clear, lipid-containing cytoplasm (xanthoma cells), consistent with xanthogranulomatous cholecystitis.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Cleveland Clinic, Cleveland, OH.

ABSTRACT
We present a 42-year-old man with a 1-month history of painless jaundice, dark urine, clay-colored stools, and a 13.5-kg weight loss. Laboratory tests revealed elevated liver enzymes and CA19-9. Imaging showed dilation of both the intra- and extrahepatic bile ducts, narrowing of the bile duct at the junction of the common bile duct and common hepatic duct, and a hypoechoic mass involving the neck of the gallbladder and the muscularis propria of the duodenum. Examination of the resected gallbladder and perihilar nodes ruled out malignancy and revealed a diffuse inflammatory infiltrate of giant histiocytes with clear, lipid-containing cytoplasm (xanthoma cells), consistent with xanthogranulomatous cholecystitis.

No MeSH data available.


Related in: MedlinePlus