Limits...
Advanced Esophageal Squamous Cell Dysplasia and Early Carcinoma Detected After Remote Esophagectomy for Adenocarcinoma.

Shafa S, Madanick RD - ACG Case Rep J (2015)

Bottom Line: We present a case of squamous dysplasia and early squamous carcinoma of the esophagus after esophagectomy for esophageal adenocarcinoma.We briefly discuss mucosectomy and ablative therapy as potential treatment options.

View Article: PubMed Central - PubMed

Affiliation: Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC.

ABSTRACT
We present a case of squamous dysplasia and early squamous carcinoma of the esophagus after esophagectomy for esophageal adenocarcinoma. We briefly discuss mucosectomy and ablative therapy as potential treatment options.

No MeSH data available.


Related in: MedlinePlus

Staining of the remnant esophagus with Lugol's solution, which is absorbed by the glycogen-containing normal squamous epithelium, turning dark brown. Areas of dysplasia or cancer remain unstained allowing targeted therapeutic approach. (A) Focal non-staining areas are seen in the distal esophagus immediately proximal to the nodularity, and (B) more diffuse non-staining areas are seen in the middle of the remnant esophagus.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4612751&req=5

Figure 3: Staining of the remnant esophagus with Lugol's solution, which is absorbed by the glycogen-containing normal squamous epithelium, turning dark brown. Areas of dysplasia or cancer remain unstained allowing targeted therapeutic approach. (A) Focal non-staining areas are seen in the distal esophagus immediately proximal to the nodularity, and (B) more diffuse non-staining areas are seen in the middle of the remnant esophagus.

Mentions: In 2013, due to concerns that the findings had changed, examination of the squamous mucosa of the distal remnant esophagus proximal to the nodules revealed several new whitish granular plaques (Figure 2). The biopsy results from these plaques revealed high-grade dysplasia with squamous carcinoma in situ. Immunohistochemical staining was positive for p63, suggesting high proliferation and a highly dysplastic pattern in these areas. High-risk human papillomavirus (HPV) infection was excluded from these areas using in situ hybridization. Chromoendoscopy using Lugol's solution to assess for voiding areas revealed focal non-staining areas just proximal to the nodules in the distal remnant of the esophagus, with more extensive non-staining areas in the mid-esophagus, 25-27 cm from the incisors (Figure 3).


Advanced Esophageal Squamous Cell Dysplasia and Early Carcinoma Detected After Remote Esophagectomy for Adenocarcinoma.

Shafa S, Madanick RD - ACG Case Rep J (2015)

Staining of the remnant esophagus with Lugol's solution, which is absorbed by the glycogen-containing normal squamous epithelium, turning dark brown. Areas of dysplasia or cancer remain unstained allowing targeted therapeutic approach. (A) Focal non-staining areas are seen in the distal esophagus immediately proximal to the nodularity, and (B) more diffuse non-staining areas are seen in the middle of the remnant esophagus.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4612751&req=5

Figure 3: Staining of the remnant esophagus with Lugol's solution, which is absorbed by the glycogen-containing normal squamous epithelium, turning dark brown. Areas of dysplasia or cancer remain unstained allowing targeted therapeutic approach. (A) Focal non-staining areas are seen in the distal esophagus immediately proximal to the nodularity, and (B) more diffuse non-staining areas are seen in the middle of the remnant esophagus.
Mentions: In 2013, due to concerns that the findings had changed, examination of the squamous mucosa of the distal remnant esophagus proximal to the nodules revealed several new whitish granular plaques (Figure 2). The biopsy results from these plaques revealed high-grade dysplasia with squamous carcinoma in situ. Immunohistochemical staining was positive for p63, suggesting high proliferation and a highly dysplastic pattern in these areas. High-risk human papillomavirus (HPV) infection was excluded from these areas using in situ hybridization. Chromoendoscopy using Lugol's solution to assess for voiding areas revealed focal non-staining areas just proximal to the nodules in the distal remnant of the esophagus, with more extensive non-staining areas in the mid-esophagus, 25-27 cm from the incisors (Figure 3).

Bottom Line: We present a case of squamous dysplasia and early squamous carcinoma of the esophagus after esophagectomy for esophageal adenocarcinoma.We briefly discuss mucosectomy and ablative therapy as potential treatment options.

View Article: PubMed Central - PubMed

Affiliation: Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC.

ABSTRACT
We present a case of squamous dysplasia and early squamous carcinoma of the esophagus after esophagectomy for esophageal adenocarcinoma. We briefly discuss mucosectomy and ablative therapy as potential treatment options.

No MeSH data available.


Related in: MedlinePlus