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Association of Serum Chemerin Levels with Acute Ischemic Stroke and Carotid Artery Atherosclerosis in a Chinese Population.

Zhao D, Bi G, Feng J, Huang R, Chen X - Med. Sci. Monit. (2015)

Bottom Line: Compared with the non-unstable plaque group, there were significant differences from the unstable plaque group in serum chemerin level (p<0.01).The levels of serum chemerin in the subjects with no carotid artery plaque were significantly lower than in those with carotid artery plaques of 2 and ≥3 (P=0.013; P=0.01).The results of this study suggest that the serum chemerin level may be an independent risk factor for AIS and carotid artery plaque instability in Chinese populations.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning, China (mainland).

ABSTRACT

Background: The aim of this study was to examine the association between serum level of chemerin with AIS and carotid artery atherosclerosis, and to investigate the level of chemerin as a potential novel cerebrovascular risk factor.

Material and methods: We compared the serum chemerin levels and cerebrovascular parameters between 70 AIS patients and 70 non-AIS subjects in a Chinese population. Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of serum chemerin. The state of carotid artery plaques in the AIS group was detected by color Doppler ultrasound. We used SPSS software for statistical analysis.

Results: Compared with the non-AIS group, serum level of chemerin in the AIS group increased significantly (p<0.01). Multivariable logistic regression suggested that serum chemerin level, neutrophil count, and BMI were independent risk factors for AIS (p<0.05). Compared with the non-unstable plaque group, there were significant differences from the unstable plaque group in serum chemerin level (p<0.01). Multivariable logistic regression analysis revealed that the LDL-C, FIB, and serum chemerin levels were independent risk factors for carotid artery plaque instability (P<0.05). The levels of serum chemerin in the subjects with no carotid artery plaque were significantly lower than in those with carotid artery plaques of 2 and ≥3 (P=0.013; P=0.01).

Conclusions: The results of this study suggest that the serum chemerin level may be an independent risk factor for AIS and carotid artery plaque instability in Chinese populations.

No MeSH data available.


Related in: MedlinePlus

The comparison of serum chemerin levels according to the number of carotid atherosclerotic plaque in acute ischemic stroke group.
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f3-medscimonit-21-3121: The comparison of serum chemerin levels according to the number of carotid atherosclerotic plaque in acute ischemic stroke group.

Mentions: When all subjects in the AIS group were further divided into 4 groups according to the number of carotid artery atherosclerosis plaques (n=0, 1, 2, ≥3), the serum chemerin levels were 80.82 (72.21–84.05), 83.08 (81.53–90.25), 87.95 (81.76–93.57, and 86.86 (84.24–94.84) ng/mL for the plaques numbers of 0, 1, 2, and ≥3, respectively. The levels of serum chemerin in the subjects with no carotid artery plaque were significantly lower than those with carotid artery plaques of 2 and ≥3 (P=0.013; P=0.01), but there was no significant difference in plaque number of 1 (p=0.284). The serum chemerin levels were not significantly different among groups in plaques numbers ≥1 (P>0.05, Figure 3).


Association of Serum Chemerin Levels with Acute Ischemic Stroke and Carotid Artery Atherosclerosis in a Chinese Population.

Zhao D, Bi G, Feng J, Huang R, Chen X - Med. Sci. Monit. (2015)

The comparison of serum chemerin levels according to the number of carotid atherosclerotic plaque in acute ischemic stroke group.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4612685&req=5

f3-medscimonit-21-3121: The comparison of serum chemerin levels according to the number of carotid atherosclerotic plaque in acute ischemic stroke group.
Mentions: When all subjects in the AIS group were further divided into 4 groups according to the number of carotid artery atherosclerosis plaques (n=0, 1, 2, ≥3), the serum chemerin levels were 80.82 (72.21–84.05), 83.08 (81.53–90.25), 87.95 (81.76–93.57, and 86.86 (84.24–94.84) ng/mL for the plaques numbers of 0, 1, 2, and ≥3, respectively. The levels of serum chemerin in the subjects with no carotid artery plaque were significantly lower than those with carotid artery plaques of 2 and ≥3 (P=0.013; P=0.01), but there was no significant difference in plaque number of 1 (p=0.284). The serum chemerin levels were not significantly different among groups in plaques numbers ≥1 (P>0.05, Figure 3).

Bottom Line: Compared with the non-unstable plaque group, there were significant differences from the unstable plaque group in serum chemerin level (p<0.01).The levels of serum chemerin in the subjects with no carotid artery plaque were significantly lower than in those with carotid artery plaques of 2 and ≥3 (P=0.013; P=0.01).The results of this study suggest that the serum chemerin level may be an independent risk factor for AIS and carotid artery plaque instability in Chinese populations.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning, China (mainland).

ABSTRACT

Background: The aim of this study was to examine the association between serum level of chemerin with AIS and carotid artery atherosclerosis, and to investigate the level of chemerin as a potential novel cerebrovascular risk factor.

Material and methods: We compared the serum chemerin levels and cerebrovascular parameters between 70 AIS patients and 70 non-AIS subjects in a Chinese population. Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of serum chemerin. The state of carotid artery plaques in the AIS group was detected by color Doppler ultrasound. We used SPSS software for statistical analysis.

Results: Compared with the non-AIS group, serum level of chemerin in the AIS group increased significantly (p<0.01). Multivariable logistic regression suggested that serum chemerin level, neutrophil count, and BMI were independent risk factors for AIS (p<0.05). Compared with the non-unstable plaque group, there were significant differences from the unstable plaque group in serum chemerin level (p<0.01). Multivariable logistic regression analysis revealed that the LDL-C, FIB, and serum chemerin levels were independent risk factors for carotid artery plaque instability (P<0.05). The levels of serum chemerin in the subjects with no carotid artery plaque were significantly lower than in those with carotid artery plaques of 2 and ≥3 (P=0.013; P=0.01).

Conclusions: The results of this study suggest that the serum chemerin level may be an independent risk factor for AIS and carotid artery plaque instability in Chinese populations.

No MeSH data available.


Related in: MedlinePlus