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Association of Serum Chemerin Levels with Acute Ischemic Stroke and Carotid Artery Atherosclerosis in a Chinese Population.

Zhao D, Bi G, Feng J, Huang R, Chen X - Med. Sci. Monit. (2015)

Bottom Line: Compared with the non-unstable plaque group, there were significant differences from the unstable plaque group in serum chemerin level (p<0.01).The levels of serum chemerin in the subjects with no carotid artery plaque were significantly lower than in those with carotid artery plaques of 2 and ≥3 (P=0.013; P=0.01).The results of this study suggest that the serum chemerin level may be an independent risk factor for AIS and carotid artery plaque instability in Chinese populations.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning, China (mainland).

ABSTRACT

Background: The aim of this study was to examine the association between serum level of chemerin with AIS and carotid artery atherosclerosis, and to investigate the level of chemerin as a potential novel cerebrovascular risk factor.

Material and methods: We compared the serum chemerin levels and cerebrovascular parameters between 70 AIS patients and 70 non-AIS subjects in a Chinese population. Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of serum chemerin. The state of carotid artery plaques in the AIS group was detected by color Doppler ultrasound. We used SPSS software for statistical analysis.

Results: Compared with the non-AIS group, serum level of chemerin in the AIS group increased significantly (p<0.01). Multivariable logistic regression suggested that serum chemerin level, neutrophil count, and BMI were independent risk factors for AIS (p<0.05). Compared with the non-unstable plaque group, there were significant differences from the unstable plaque group in serum chemerin level (p<0.01). Multivariable logistic regression analysis revealed that the LDL-C, FIB, and serum chemerin levels were independent risk factors for carotid artery plaque instability (P<0.05). The levels of serum chemerin in the subjects with no carotid artery plaque were significantly lower than in those with carotid artery plaques of 2 and ≥3 (P=0.013; P=0.01).

Conclusions: The results of this study suggest that the serum chemerin level may be an independent risk factor for AIS and carotid artery plaque instability in Chinese populations.

No MeSH data available.


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The comparison of serum chemerin levels and carotid atherosclerotic plaque stability.
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f2-medscimonit-21-3121: The comparison of serum chemerin levels and carotid atherosclerotic plaque stability.

Mentions: Table 4 shows the demographic and clinical characteristics of the no plaque group (n=8), stable plaques group (n=8), and unstable plaques group (Group B; n=54). We combined the groups with no plaque and stable plaques as the non-unstable plaques group (Group A; n=16). There was no statistical difference between the groups with stable plaques and non-plaque in serum chemerin levels (83.76 (80.07–88.93) vs. 81.22 (74.00–83.47) ng/mL, P=0.279), while both of them were significantly different from the unstable plaques group in which serum level was 86.86 (83.85–95.22) ng/mL (P<0.01; P=0.05, respectively). Significant differences in sex, SBP, dyslipidemia, NC, hypertension, and smoking history were found between Group A and Group B (P<0.05~0.01). There were significant difference between the 2 groups in terms of FIB and hs-CRP levels (P<0.05); TG, TC, and LDL-C levels (P<0.01). Serum chemerin levels of patients in Group B were 86.86 (83.85–95.22) ng/mL, significantly higher than those in Group A, which were 82.22 (79.36–85.23) ng/mL (P<0.01, Figure 2). We tested for possible associations between the stability of carotid artery atherosclerosis plaques and their risk factors using multiple logistic regression analysis, with the stability of carotid artery atherosclerosis plaques in AIS as the dependent variable. We found that LDL, FIB, and serum chemerin levels were the independent risk factors for the instability of carotid artery atherosclerosis plaques (P<0.05, Table 5).


Association of Serum Chemerin Levels with Acute Ischemic Stroke and Carotid Artery Atherosclerosis in a Chinese Population.

Zhao D, Bi G, Feng J, Huang R, Chen X - Med. Sci. Monit. (2015)

The comparison of serum chemerin levels and carotid atherosclerotic plaque stability.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4612685&req=5

f2-medscimonit-21-3121: The comparison of serum chemerin levels and carotid atherosclerotic plaque stability.
Mentions: Table 4 shows the demographic and clinical characteristics of the no plaque group (n=8), stable plaques group (n=8), and unstable plaques group (Group B; n=54). We combined the groups with no plaque and stable plaques as the non-unstable plaques group (Group A; n=16). There was no statistical difference between the groups with stable plaques and non-plaque in serum chemerin levels (83.76 (80.07–88.93) vs. 81.22 (74.00–83.47) ng/mL, P=0.279), while both of them were significantly different from the unstable plaques group in which serum level was 86.86 (83.85–95.22) ng/mL (P<0.01; P=0.05, respectively). Significant differences in sex, SBP, dyslipidemia, NC, hypertension, and smoking history were found between Group A and Group B (P<0.05~0.01). There were significant difference between the 2 groups in terms of FIB and hs-CRP levels (P<0.05); TG, TC, and LDL-C levels (P<0.01). Serum chemerin levels of patients in Group B were 86.86 (83.85–95.22) ng/mL, significantly higher than those in Group A, which were 82.22 (79.36–85.23) ng/mL (P<0.01, Figure 2). We tested for possible associations between the stability of carotid artery atherosclerosis plaques and their risk factors using multiple logistic regression analysis, with the stability of carotid artery atherosclerosis plaques in AIS as the dependent variable. We found that LDL, FIB, and serum chemerin levels were the independent risk factors for the instability of carotid artery atherosclerosis plaques (P<0.05, Table 5).

Bottom Line: Compared with the non-unstable plaque group, there were significant differences from the unstable plaque group in serum chemerin level (p<0.01).The levels of serum chemerin in the subjects with no carotid artery plaque were significantly lower than in those with carotid artery plaques of 2 and ≥3 (P=0.013; P=0.01).The results of this study suggest that the serum chemerin level may be an independent risk factor for AIS and carotid artery plaque instability in Chinese populations.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning, China (mainland).

ABSTRACT

Background: The aim of this study was to examine the association between serum level of chemerin with AIS and carotid artery atherosclerosis, and to investigate the level of chemerin as a potential novel cerebrovascular risk factor.

Material and methods: We compared the serum chemerin levels and cerebrovascular parameters between 70 AIS patients and 70 non-AIS subjects in a Chinese population. Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of serum chemerin. The state of carotid artery plaques in the AIS group was detected by color Doppler ultrasound. We used SPSS software for statistical analysis.

Results: Compared with the non-AIS group, serum level of chemerin in the AIS group increased significantly (p<0.01). Multivariable logistic regression suggested that serum chemerin level, neutrophil count, and BMI were independent risk factors for AIS (p<0.05). Compared with the non-unstable plaque group, there were significant differences from the unstable plaque group in serum chemerin level (p<0.01). Multivariable logistic regression analysis revealed that the LDL-C, FIB, and serum chemerin levels were independent risk factors for carotid artery plaque instability (P<0.05). The levels of serum chemerin in the subjects with no carotid artery plaque were significantly lower than in those with carotid artery plaques of 2 and ≥3 (P=0.013; P=0.01).

Conclusions: The results of this study suggest that the serum chemerin level may be an independent risk factor for AIS and carotid artery plaque instability in Chinese populations.

No MeSH data available.


Related in: MedlinePlus