Limits...
Association of Serum Chemerin Levels with Acute Ischemic Stroke and Carotid Artery Atherosclerosis in a Chinese Population.

Zhao D, Bi G, Feng J, Huang R, Chen X - Med. Sci. Monit. (2015)

Bottom Line: Compared with the non-unstable plaque group, there were significant differences from the unstable plaque group in serum chemerin level (p<0.01).The levels of serum chemerin in the subjects with no carotid artery plaque were significantly lower than in those with carotid artery plaques of 2 and ≥3 (P=0.013; P=0.01).The results of this study suggest that the serum chemerin level may be an independent risk factor for AIS and carotid artery plaque instability in Chinese populations.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning, China (mainland).

ABSTRACT

Background: The aim of this study was to examine the association between serum level of chemerin with AIS and carotid artery atherosclerosis, and to investigate the level of chemerin as a potential novel cerebrovascular risk factor.

Material and methods: We compared the serum chemerin levels and cerebrovascular parameters between 70 AIS patients and 70 non-AIS subjects in a Chinese population. Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of serum chemerin. The state of carotid artery plaques in the AIS group was detected by color Doppler ultrasound. We used SPSS software for statistical analysis.

Results: Compared with the non-AIS group, serum level of chemerin in the AIS group increased significantly (p<0.01). Multivariable logistic regression suggested that serum chemerin level, neutrophil count, and BMI were independent risk factors for AIS (p<0.05). Compared with the non-unstable plaque group, there were significant differences from the unstable plaque group in serum chemerin level (p<0.01). Multivariable logistic regression analysis revealed that the LDL-C, FIB, and serum chemerin levels were independent risk factors for carotid artery plaque instability (P<0.05). The levels of serum chemerin in the subjects with no carotid artery plaque were significantly lower than in those with carotid artery plaques of 2 and ≥3 (P=0.013; P=0.01).

Conclusions: The results of this study suggest that the serum chemerin level may be an independent risk factor for AIS and carotid artery plaque instability in Chinese populations.

No MeSH data available.


Related in: MedlinePlus

The comparison of serum chemerin levels between AIS and non-AIS groups AIS acute ischemic stroke.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4612685&req=5

f1-medscimonit-21-3121: The comparison of serum chemerin levels between AIS and non-AIS groups AIS acute ischemic stroke.

Mentions: Laboratory findings and anthropometric characteristics of the subjects in AIS (N=70) and non-AIS (N=70) groups are summarized in Table 1. Patients with AIS had higher BMI, TG, FIB, and hypertension history than those of the non-AIS group (P<0.05). Significant differences in FPG, WBC, neutrophil count, and hs-CRP levels were found between the 2 groups (P<0.01). No significant differences were found regarding age, sex, WC, NC, BP, HR, smoking history, diabetes, dyslipidemia, and positive family history of stroke. As expected, there was a significantly difference between two groups in serum chemerin levels (62.96 (58.38–72.15) vs. 85.69 (82.99–91.62) ng/mL, P<0.01, Table 1, Figure 1). We tested for possible associations between AIS and its risk factors using multiple logistic regression analysis, with AIS as the dependent variable. We found that BMI, neutrophil count, and chemerin were the independent risk factors for AIS (P<0.05~0.01, Table 2).


Association of Serum Chemerin Levels with Acute Ischemic Stroke and Carotid Artery Atherosclerosis in a Chinese Population.

Zhao D, Bi G, Feng J, Huang R, Chen X - Med. Sci. Monit. (2015)

The comparison of serum chemerin levels between AIS and non-AIS groups AIS acute ischemic stroke.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4612685&req=5

f1-medscimonit-21-3121: The comparison of serum chemerin levels between AIS and non-AIS groups AIS acute ischemic stroke.
Mentions: Laboratory findings and anthropometric characteristics of the subjects in AIS (N=70) and non-AIS (N=70) groups are summarized in Table 1. Patients with AIS had higher BMI, TG, FIB, and hypertension history than those of the non-AIS group (P<0.05). Significant differences in FPG, WBC, neutrophil count, and hs-CRP levels were found between the 2 groups (P<0.01). No significant differences were found regarding age, sex, WC, NC, BP, HR, smoking history, diabetes, dyslipidemia, and positive family history of stroke. As expected, there was a significantly difference between two groups in serum chemerin levels (62.96 (58.38–72.15) vs. 85.69 (82.99–91.62) ng/mL, P<0.01, Table 1, Figure 1). We tested for possible associations between AIS and its risk factors using multiple logistic regression analysis, with AIS as the dependent variable. We found that BMI, neutrophil count, and chemerin were the independent risk factors for AIS (P<0.05~0.01, Table 2).

Bottom Line: Compared with the non-unstable plaque group, there were significant differences from the unstable plaque group in serum chemerin level (p<0.01).The levels of serum chemerin in the subjects with no carotid artery plaque were significantly lower than in those with carotid artery plaques of 2 and ≥3 (P=0.013; P=0.01).The results of this study suggest that the serum chemerin level may be an independent risk factor for AIS and carotid artery plaque instability in Chinese populations.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning, China (mainland).

ABSTRACT

Background: The aim of this study was to examine the association between serum level of chemerin with AIS and carotid artery atherosclerosis, and to investigate the level of chemerin as a potential novel cerebrovascular risk factor.

Material and methods: We compared the serum chemerin levels and cerebrovascular parameters between 70 AIS patients and 70 non-AIS subjects in a Chinese population. Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of serum chemerin. The state of carotid artery plaques in the AIS group was detected by color Doppler ultrasound. We used SPSS software for statistical analysis.

Results: Compared with the non-AIS group, serum level of chemerin in the AIS group increased significantly (p<0.01). Multivariable logistic regression suggested that serum chemerin level, neutrophil count, and BMI were independent risk factors for AIS (p<0.05). Compared with the non-unstable plaque group, there were significant differences from the unstable plaque group in serum chemerin level (p<0.01). Multivariable logistic regression analysis revealed that the LDL-C, FIB, and serum chemerin levels were independent risk factors for carotid artery plaque instability (P<0.05). The levels of serum chemerin in the subjects with no carotid artery plaque were significantly lower than in those with carotid artery plaques of 2 and ≥3 (P=0.013; P=0.01).

Conclusions: The results of this study suggest that the serum chemerin level may be an independent risk factor for AIS and carotid artery plaque instability in Chinese populations.

No MeSH data available.


Related in: MedlinePlus