Limits...
Post-mortem brain pathology is related to declining respiratory function in community-dwelling older adults.

Buchman AS, Yu L, Wilson RS, Dawe RJ, VanderHorst V, Schneider JA, Bennett DA - Front Aging Neurosci (2015)

Bottom Line: Nigral neuronal loss was associated with the person-specific decline in SPI (Estimate, -0.016 unit/year, S.E. 0.006, p = 0.009) and reduction of the slope variance was equal to 4%.By contrast, Alzheimer's disease (AD) pathology (Estimate, -0.030 unit/year, S.E. 0.009, p < 0.001) and macroscopic infarcts (-0.033 unit/year, S.E., 0.011, p = 0.003) were associated with the person-specific decline in RMS and reduction of the slope variance was equal to 7%.These results suggest that brain pathology is associated with the rate of declining respiratory function in older adults.

View Article: PubMed Central - PubMed

Affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center Chicago, IL, USA ; Department of Neurological Sciences, Rush University Medical Center Chicago, IL, USA.

ABSTRACT
Damage to brain structures which constitute the distributed neural network that integrates respiratory muscle and pulmonary functions, can impair adequate ventilation and its volitional control. We tested the hypothesis that the level of brain pathology in older adults is associated with declining respiratory function measured during life. 1,409 older adults had annual testing with spirometry (SPI) and respiratory muscle strength (RMS) based on maximal inspiratory and maximal expiratory pressures (MEPs). Those who died underwent structured brain autopsy. On average, during 5 years of follow-up, SPI and RMS showed progressive decline which was moderately correlated (ρ = 0.57, p < 0.001). Among decedents (N = 447), indices of brain neuropathologies showed differential associations with declining SPI and RMS. Nigral neuronal loss was associated with the person-specific decline in SPI (Estimate, -0.016 unit/year, S.E. 0.006, p = 0.009) and reduction of the slope variance was equal to 4%. By contrast, Alzheimer's disease (AD) pathology (Estimate, -0.030 unit/year, S.E. 0.009, p < 0.001) and macroscopic infarcts (-0.033 unit/year, S.E., 0.011, p = 0.003) were associated with the person-specific decline in RMS and reduction of the slope variance was equal to 7%. These results suggest that brain pathology is associated with the rate of declining respiratory function in older adults.

No MeSH data available.


Related in: MedlinePlus

Change in spirometry (SPI) and respiratory muscle strength (RMS) and the effect of more brain pathology on their rates of change. The left panels show change in SPI (top) and RMS (bottom) during the study. Crude paths of change (gray lines) and mean paths of change predicted by the model (black lines) in SPI (top) and RMS (bottom). To facilitate visualization data from a 25% random sample of decedents is illustrated in the left panels. To display the association of brain pathology on the rate of change in respiration, four hypothetical average participants with their estimated rate of declining respiration based on the model which included all the cases analyzed in this study are illustrated. The right panels show the model derived predicted paths of SPI (top) and RMS (bottom) for four participants with increasing burden of brain pathology: (1) Black line, the predicted path for a participant with No pathology; (2) Red line, the predicted path for a participant with Alzheimer’s disease (AD) pathology; (3) Green line, the predicted path for a participant with AD pathology and macroinfarcts; (4) Blue line, the predicted path for a participant with AD pathology, macroinfarcts and severe nigral neuronal loss.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4612667&req=5

Figure 1: Change in spirometry (SPI) and respiratory muscle strength (RMS) and the effect of more brain pathology on their rates of change. The left panels show change in SPI (top) and RMS (bottom) during the study. Crude paths of change (gray lines) and mean paths of change predicted by the model (black lines) in SPI (top) and RMS (bottom). To facilitate visualization data from a 25% random sample of decedents is illustrated in the left panels. To display the association of brain pathology on the rate of change in respiration, four hypothetical average participants with their estimated rate of declining respiration based on the model which included all the cases analyzed in this study are illustrated. The right panels show the model derived predicted paths of SPI (top) and RMS (bottom) for four participants with increasing burden of brain pathology: (1) Black line, the predicted path for a participant with No pathology; (2) Red line, the predicted path for a participant with Alzheimer’s disease (AD) pathology; (3) Green line, the predicted path for a participant with AD pathology and macroinfarcts; (4) Blue line, the predicted path for a participant with AD pathology, macroinfarcts and severe nigral neuronal loss.

Mentions: During up to 13 years of follow-up, both SPI (Estimate −0.068, S.E. 0.002, p < 0.001) and RMS (Estimate −0.050, S.E. 0.002, p < 0.001) declined. Observed paths of change (gray lines) and model estimated mean paths of change (black) in SPI (top) and RMS (bottom) are illustrated on the left panel of Figure 1.


Post-mortem brain pathology is related to declining respiratory function in community-dwelling older adults.

Buchman AS, Yu L, Wilson RS, Dawe RJ, VanderHorst V, Schneider JA, Bennett DA - Front Aging Neurosci (2015)

Change in spirometry (SPI) and respiratory muscle strength (RMS) and the effect of more brain pathology on their rates of change. The left panels show change in SPI (top) and RMS (bottom) during the study. Crude paths of change (gray lines) and mean paths of change predicted by the model (black lines) in SPI (top) and RMS (bottom). To facilitate visualization data from a 25% random sample of decedents is illustrated in the left panels. To display the association of brain pathology on the rate of change in respiration, four hypothetical average participants with their estimated rate of declining respiration based on the model which included all the cases analyzed in this study are illustrated. The right panels show the model derived predicted paths of SPI (top) and RMS (bottom) for four participants with increasing burden of brain pathology: (1) Black line, the predicted path for a participant with No pathology; (2) Red line, the predicted path for a participant with Alzheimer’s disease (AD) pathology; (3) Green line, the predicted path for a participant with AD pathology and macroinfarcts; (4) Blue line, the predicted path for a participant with AD pathology, macroinfarcts and severe nigral neuronal loss.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4612667&req=5

Figure 1: Change in spirometry (SPI) and respiratory muscle strength (RMS) and the effect of more brain pathology on their rates of change. The left panels show change in SPI (top) and RMS (bottom) during the study. Crude paths of change (gray lines) and mean paths of change predicted by the model (black lines) in SPI (top) and RMS (bottom). To facilitate visualization data from a 25% random sample of decedents is illustrated in the left panels. To display the association of brain pathology on the rate of change in respiration, four hypothetical average participants with their estimated rate of declining respiration based on the model which included all the cases analyzed in this study are illustrated. The right panels show the model derived predicted paths of SPI (top) and RMS (bottom) for four participants with increasing burden of brain pathology: (1) Black line, the predicted path for a participant with No pathology; (2) Red line, the predicted path for a participant with Alzheimer’s disease (AD) pathology; (3) Green line, the predicted path for a participant with AD pathology and macroinfarcts; (4) Blue line, the predicted path for a participant with AD pathology, macroinfarcts and severe nigral neuronal loss.
Mentions: During up to 13 years of follow-up, both SPI (Estimate −0.068, S.E. 0.002, p < 0.001) and RMS (Estimate −0.050, S.E. 0.002, p < 0.001) declined. Observed paths of change (gray lines) and model estimated mean paths of change (black) in SPI (top) and RMS (bottom) are illustrated on the left panel of Figure 1.

Bottom Line: Nigral neuronal loss was associated with the person-specific decline in SPI (Estimate, -0.016 unit/year, S.E. 0.006, p = 0.009) and reduction of the slope variance was equal to 4%.By contrast, Alzheimer's disease (AD) pathology (Estimate, -0.030 unit/year, S.E. 0.009, p < 0.001) and macroscopic infarcts (-0.033 unit/year, S.E., 0.011, p = 0.003) were associated with the person-specific decline in RMS and reduction of the slope variance was equal to 7%.These results suggest that brain pathology is associated with the rate of declining respiratory function in older adults.

View Article: PubMed Central - PubMed

Affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center Chicago, IL, USA ; Department of Neurological Sciences, Rush University Medical Center Chicago, IL, USA.

ABSTRACT
Damage to brain structures which constitute the distributed neural network that integrates respiratory muscle and pulmonary functions, can impair adequate ventilation and its volitional control. We tested the hypothesis that the level of brain pathology in older adults is associated with declining respiratory function measured during life. 1,409 older adults had annual testing with spirometry (SPI) and respiratory muscle strength (RMS) based on maximal inspiratory and maximal expiratory pressures (MEPs). Those who died underwent structured brain autopsy. On average, during 5 years of follow-up, SPI and RMS showed progressive decline which was moderately correlated (ρ = 0.57, p < 0.001). Among decedents (N = 447), indices of brain neuropathologies showed differential associations with declining SPI and RMS. Nigral neuronal loss was associated with the person-specific decline in SPI (Estimate, -0.016 unit/year, S.E. 0.006, p = 0.009) and reduction of the slope variance was equal to 4%. By contrast, Alzheimer's disease (AD) pathology (Estimate, -0.030 unit/year, S.E. 0.009, p < 0.001) and macroscopic infarcts (-0.033 unit/year, S.E., 0.011, p = 0.003) were associated with the person-specific decline in RMS and reduction of the slope variance was equal to 7%. These results suggest that brain pathology is associated with the rate of declining respiratory function in older adults.

No MeSH data available.


Related in: MedlinePlus