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Visuo-vestibular information processing by unipolar brush cells in the rabbit flocculus.

Hensbroek RA, Ruigrok TJ, van Beugen BJ, Maruta J, Simpson JI - Cerebellum (2015)

Bottom Line: The unipolar brush cell (UBC) is a glutamatergic granular layer interneuron that is predominantly located in the vestibulocerebellum and parts of the vermis.In the anesthetized rabbit, the activity of the presumed UBC units displayed a wide variety of modulation profiles that could be related to aspects of head velocity or acceleration.These modulation profiles could also be found in the awake rabbit where, in addition, they could also carry an eye position signal.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience & Physiology, New York University Medical School, New York, NY, 10016, USA.

ABSTRACT
The unipolar brush cell (UBC) is a glutamatergic granular layer interneuron that is predominantly located in the vestibulocerebellum and parts of the vermis. In rat and rabbit, we previously found using juxtacellular labeling combined with spontaneous activity recording that cells with highly regular spontaneous activity belong to the UBC category. Making use of this signature, we recorded from floccular UBCs in both anesthetized and awake rabbits while delivering visuo-vestibular stimulation by using sigmoidal rotation of the whole animal. In the anesthetized rabbit, the activity of the presumed UBC units displayed a wide variety of modulation profiles that could be related to aspects of head velocity or acceleration. These modulation profiles could also be found in the awake rabbit where, in addition, they could also carry an eye position signal. Furthermore, units in the awake rabbit could demonstrate rather long response latencies of up to 0.5 s. We suggest that the UBCs recorded in this study mostly belong to the type I UBC category (calretinin-positive) and that they can play diverse roles in floccular visuo-vestibular information processing, such as transformation of velocity-related signals to acceleration-related signals.

No MeSH data available.


Related in: MedlinePlus

Response properties of floccular UBCs in the awake rabbit. a Example (unit RB01.31b.2) that signaled only eye position. Top left panel, ISI histogram showing spike intervals during spontaneous activity expressed as normalized counts; top right panel, sequential log interspike intervals over a period of 30 s of spontaneous activity; middle panel, the sigmoidal head movement provided in the light by a computer-controlled motorized turntable (also used in (b) and (c)) and the evoked compensatory eye movement (in blue); bottom panel, modulation profile (average of 7 cycles) in response to the head movement shown in the middle panel. The 0 reference in the time line indicates the time of a trigger pulse in the computer command (also for (b) and (c)). Panels are arranged similarly in (b) and (c). b Example (unit RB01.32.4) displaying eye position and head velocity profiles with the same response polarity (average of 19 cycles). c Example (unit RB01.11.6) that in comparison to the unit shown in Fig. 2b has an oppositely directed velocity profile, but a similarly directed position profile (average of 6 cycles) (Color figure online)
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Fig2: Response properties of floccular UBCs in the awake rabbit. a Example (unit RB01.31b.2) that signaled only eye position. Top left panel, ISI histogram showing spike intervals during spontaneous activity expressed as normalized counts; top right panel, sequential log interspike intervals over a period of 30 s of spontaneous activity; middle panel, the sigmoidal head movement provided in the light by a computer-controlled motorized turntable (also used in (b) and (c)) and the evoked compensatory eye movement (in blue); bottom panel, modulation profile (average of 7 cycles) in response to the head movement shown in the middle panel. The 0 reference in the time line indicates the time of a trigger pulse in the computer command (also for (b) and (c)). Panels are arranged similarly in (b) and (c). b Example (unit RB01.32.4) displaying eye position and head velocity profiles with the same response polarity (average of 19 cycles). c Example (unit RB01.11.6) that in comparison to the unit shown in Fig. 2b has an oppositely directed velocity profile, but a similarly directed position profile (average of 6 cycles) (Color figure online)

Mentions: Relevant measures of spontaneous activity characteristics used to decide upon the UBC nature of the units shown in Figs. 1 and 2


Visuo-vestibular information processing by unipolar brush cells in the rabbit flocculus.

Hensbroek RA, Ruigrok TJ, van Beugen BJ, Maruta J, Simpson JI - Cerebellum (2015)

Response properties of floccular UBCs in the awake rabbit. a Example (unit RB01.31b.2) that signaled only eye position. Top left panel, ISI histogram showing spike intervals during spontaneous activity expressed as normalized counts; top right panel, sequential log interspike intervals over a period of 30 s of spontaneous activity; middle panel, the sigmoidal head movement provided in the light by a computer-controlled motorized turntable (also used in (b) and (c)) and the evoked compensatory eye movement (in blue); bottom panel, modulation profile (average of 7 cycles) in response to the head movement shown in the middle panel. The 0 reference in the time line indicates the time of a trigger pulse in the computer command (also for (b) and (c)). Panels are arranged similarly in (b) and (c). b Example (unit RB01.32.4) displaying eye position and head velocity profiles with the same response polarity (average of 19 cycles). c Example (unit RB01.11.6) that in comparison to the unit shown in Fig. 2b has an oppositely directed velocity profile, but a similarly directed position profile (average of 6 cycles) (Color figure online)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4612327&req=5

Fig2: Response properties of floccular UBCs in the awake rabbit. a Example (unit RB01.31b.2) that signaled only eye position. Top left panel, ISI histogram showing spike intervals during spontaneous activity expressed as normalized counts; top right panel, sequential log interspike intervals over a period of 30 s of spontaneous activity; middle panel, the sigmoidal head movement provided in the light by a computer-controlled motorized turntable (also used in (b) and (c)) and the evoked compensatory eye movement (in blue); bottom panel, modulation profile (average of 7 cycles) in response to the head movement shown in the middle panel. The 0 reference in the time line indicates the time of a trigger pulse in the computer command (also for (b) and (c)). Panels are arranged similarly in (b) and (c). b Example (unit RB01.32.4) displaying eye position and head velocity profiles with the same response polarity (average of 19 cycles). c Example (unit RB01.11.6) that in comparison to the unit shown in Fig. 2b has an oppositely directed velocity profile, but a similarly directed position profile (average of 6 cycles) (Color figure online)
Mentions: Relevant measures of spontaneous activity characteristics used to decide upon the UBC nature of the units shown in Figs. 1 and 2

Bottom Line: The unipolar brush cell (UBC) is a glutamatergic granular layer interneuron that is predominantly located in the vestibulocerebellum and parts of the vermis.In the anesthetized rabbit, the activity of the presumed UBC units displayed a wide variety of modulation profiles that could be related to aspects of head velocity or acceleration.These modulation profiles could also be found in the awake rabbit where, in addition, they could also carry an eye position signal.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience & Physiology, New York University Medical School, New York, NY, 10016, USA.

ABSTRACT
The unipolar brush cell (UBC) is a glutamatergic granular layer interneuron that is predominantly located in the vestibulocerebellum and parts of the vermis. In rat and rabbit, we previously found using juxtacellular labeling combined with spontaneous activity recording that cells with highly regular spontaneous activity belong to the UBC category. Making use of this signature, we recorded from floccular UBCs in both anesthetized and awake rabbits while delivering visuo-vestibular stimulation by using sigmoidal rotation of the whole animal. In the anesthetized rabbit, the activity of the presumed UBC units displayed a wide variety of modulation profiles that could be related to aspects of head velocity or acceleration. These modulation profiles could also be found in the awake rabbit where, in addition, they could also carry an eye position signal. Furthermore, units in the awake rabbit could demonstrate rather long response latencies of up to 0.5 s. We suggest that the UBCs recorded in this study mostly belong to the type I UBC category (calretinin-positive) and that they can play diverse roles in floccular visuo-vestibular information processing, such as transformation of velocity-related signals to acceleration-related signals.

No MeSH data available.


Related in: MedlinePlus