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A Systematic Review of the Acute Effects of Exercise on Immune and Inflammatory Indices in Untrained Adults.

Brown WM, Davison GW, McClean CM, Murphy MH - Sports Med Open (2015)

Bottom Line: MEDLINE, EMBASE, CINAHL, Sports Discus and Cochrane were searched for relevant studies published from January 1946 to May 2013.Ten studies met the inclusion criteria.The acute response of CRP within the included studies is equivocal.

View Article: PubMed Central - PubMed

Affiliation: Sport and Exercise Sciences Research Institute, Ulster University, Jordanstown, BT37 0QB Northern Ireland.

ABSTRACT

Background: Cardiovascular disease (CVD) is the leading cause of global mortality. Although the incidence may be reduced with regular exercise, the health benefits of a single bout of exercise on selected CVD risk factors are not well understood. The primary objective of this review is to consider the transient effects of exercise on immune (neutrophil count) and inflammatory (interleukin-6 [IL-6], C-reactive protein [CRP]) markers in untrained adults.

Methods: MEDLINE, EMBASE, CINAHL, Sports Discus and Cochrane were searched for relevant studies published from January 1946 to May 2013. Randomised controlled or crossover studies which measured any of these parameters in untrained but otherwise healthy participants in the 48 h following about of exercise, less than 1 h in duration were included.

Results: Ten studies met the inclusion criteria. The results indicate a single bout of aerobic or resistance exercise of moderate to high intensity promotes an increase in IL-6 (145 %) and neutrophil counts (51 %). It appears that 30-60 min of moderate to high intensity exercise is necessary to elicit such changes although variables such as the mode, intensity and pattern of exercise also affect the response. The acute response of CRP within the included studies is equivocal.

Conclusions: Although responses to CRP are inconsistent, a single bout of exercise can increase the activity of both circulating IL-6 and neutrophil counts in untrained adults. These immune and inflammatory responses to a single bout of exercise may be linked to a range of health benefits.

No MeSH data available.


Related in: MedlinePlus

Risk of bias summary for included studies
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Fig2: Risk of bias summary for included studies

Mentions: A PRISMA schematic for the searching strategy is outlined in Fig. 1. Initial searches revealed 96 original articles as possible studies for inclusion. Ten studies met the inclusion criteria and were eligible for inclusion in the current review [2, 4, 7, 16, 28, 40, 43, 50, 58, 66]. A summary of each study, including baseline to post-exercise responses, can be observed in Table 1. All studies incorporated a resting control group alongside one or two suitable exercise trials of differing intensity, pattern and/or duration. Two studies had a ‘high’ risk of bias rating for reporting and other biases, although all remaining studies were categorised as having an ‘unclear’ or ‘low’ risk of bias (see Fig. 2).Fig. 1


A Systematic Review of the Acute Effects of Exercise on Immune and Inflammatory Indices in Untrained Adults.

Brown WM, Davison GW, McClean CM, Murphy MH - Sports Med Open (2015)

Risk of bias summary for included studies
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4612317&req=5

Fig2: Risk of bias summary for included studies
Mentions: A PRISMA schematic for the searching strategy is outlined in Fig. 1. Initial searches revealed 96 original articles as possible studies for inclusion. Ten studies met the inclusion criteria and were eligible for inclusion in the current review [2, 4, 7, 16, 28, 40, 43, 50, 58, 66]. A summary of each study, including baseline to post-exercise responses, can be observed in Table 1. All studies incorporated a resting control group alongside one or two suitable exercise trials of differing intensity, pattern and/or duration. Two studies had a ‘high’ risk of bias rating for reporting and other biases, although all remaining studies were categorised as having an ‘unclear’ or ‘low’ risk of bias (see Fig. 2).Fig. 1

Bottom Line: MEDLINE, EMBASE, CINAHL, Sports Discus and Cochrane were searched for relevant studies published from January 1946 to May 2013.Ten studies met the inclusion criteria.The acute response of CRP within the included studies is equivocal.

View Article: PubMed Central - PubMed

Affiliation: Sport and Exercise Sciences Research Institute, Ulster University, Jordanstown, BT37 0QB Northern Ireland.

ABSTRACT

Background: Cardiovascular disease (CVD) is the leading cause of global mortality. Although the incidence may be reduced with regular exercise, the health benefits of a single bout of exercise on selected CVD risk factors are not well understood. The primary objective of this review is to consider the transient effects of exercise on immune (neutrophil count) and inflammatory (interleukin-6 [IL-6], C-reactive protein [CRP]) markers in untrained adults.

Methods: MEDLINE, EMBASE, CINAHL, Sports Discus and Cochrane were searched for relevant studies published from January 1946 to May 2013. Randomised controlled or crossover studies which measured any of these parameters in untrained but otherwise healthy participants in the 48 h following about of exercise, less than 1 h in duration were included.

Results: Ten studies met the inclusion criteria. The results indicate a single bout of aerobic or resistance exercise of moderate to high intensity promotes an increase in IL-6 (145 %) and neutrophil counts (51 %). It appears that 30-60 min of moderate to high intensity exercise is necessary to elicit such changes although variables such as the mode, intensity and pattern of exercise also affect the response. The acute response of CRP within the included studies is equivocal.

Conclusions: Although responses to CRP are inconsistent, a single bout of exercise can increase the activity of both circulating IL-6 and neutrophil counts in untrained adults. These immune and inflammatory responses to a single bout of exercise may be linked to a range of health benefits.

No MeSH data available.


Related in: MedlinePlus