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Use of autologous fibrin glue for endoscopic treatment of esophageal lesions.

Lucas M, Seeber P - Endosc Int Open (2015)

Bottom Line: Esophageal leaks are a potentially life-threatening condition.One treatment option is injection therapy with commercially available fibrin glue.We describe herein a method to close esophageal leaks by injecting autologous fibrin glue prepared exclusively with the patient's own blood.

View Article: PubMed Central - PubMed

Affiliation: The Institute for Blood Management, Gotha, Germany.

ABSTRACT

Background and study aims: Esophageal leaks are a potentially life-threatening condition. One treatment option is injection therapy with commercially available fibrin glue. We describe herein a method to close esophageal leaks by injecting autologous fibrin glue prepared exclusively with the patient's own blood.

No MeSH data available.


Related in: MedlinePlus

 Injection of autologous glue.
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FI217-5:  Injection of autologous glue.

Mentions: The patient consented to lavage and drainage of the chest cavity. That was performed immediately and the patient was placed on broad-spectrum antibiotics. Endoscopic treatment of the esophageal leak was then attempted, initially by clipping the lesion, but it proved technically challenging and did not succeed in closing the leak. Therefore, as a last resort, autologous fibrin glue (Fig. 4) was prepared after the patient gave informed consent. The glue was prepared and 3 × 1.5 mL of it was endoscopically injected submucosally around the leak (Fig. 5 and Fig. 6) in three different places, as described in detail in Table 1. At each endoscopic session, the procedure was repeated. Injection sessions were scheduled for Monday, Wednesday, and Friday of 2 consecutive weeks. There was no clinical evidence of tissue inflammation or necrosis after injection. On the contrary, the wound edges seemed to regain vitality. Between injection sessions, the patient was allowed to drink water and tea with sugar or honey, which helped to clean the chest cavity and kept bacterial accumulation in the chest to a minimum. After the sixth injection session, the leak was closed, as demonstrated by cessation of output from the chest drain and radiologic studies with liquid contrast medium and methylene blue (Fig. 7 and Fig. 8).


Use of autologous fibrin glue for endoscopic treatment of esophageal lesions.

Lucas M, Seeber P - Endosc Int Open (2015)

 Injection of autologous glue.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4612238&req=5

FI217-5:  Injection of autologous glue.
Mentions: The patient consented to lavage and drainage of the chest cavity. That was performed immediately and the patient was placed on broad-spectrum antibiotics. Endoscopic treatment of the esophageal leak was then attempted, initially by clipping the lesion, but it proved technically challenging and did not succeed in closing the leak. Therefore, as a last resort, autologous fibrin glue (Fig. 4) was prepared after the patient gave informed consent. The glue was prepared and 3 × 1.5 mL of it was endoscopically injected submucosally around the leak (Fig. 5 and Fig. 6) in three different places, as described in detail in Table 1. At each endoscopic session, the procedure was repeated. Injection sessions were scheduled for Monday, Wednesday, and Friday of 2 consecutive weeks. There was no clinical evidence of tissue inflammation or necrosis after injection. On the contrary, the wound edges seemed to regain vitality. Between injection sessions, the patient was allowed to drink water and tea with sugar or honey, which helped to clean the chest cavity and kept bacterial accumulation in the chest to a minimum. After the sixth injection session, the leak was closed, as demonstrated by cessation of output from the chest drain and radiologic studies with liquid contrast medium and methylene blue (Fig. 7 and Fig. 8).

Bottom Line: Esophageal leaks are a potentially life-threatening condition.One treatment option is injection therapy with commercially available fibrin glue.We describe herein a method to close esophageal leaks by injecting autologous fibrin glue prepared exclusively with the patient's own blood.

View Article: PubMed Central - PubMed

Affiliation: The Institute for Blood Management, Gotha, Germany.

ABSTRACT

Background and study aims: Esophageal leaks are a potentially life-threatening condition. One treatment option is injection therapy with commercially available fibrin glue. We describe herein a method to close esophageal leaks by injecting autologous fibrin glue prepared exclusively with the patient's own blood.

No MeSH data available.


Related in: MedlinePlus