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nextflu: real-time tracking of seasonal influenza virus evolution in humans.

Neher RA, Bedford T - Bioinformatics (2015)

Bottom Line: Seasonal influenza viruses evolve rapidly, allowing them to evade immunity in their human hosts and reinfect previously infected individuals.Similarly, vaccines against seasonal influenza need to be updated frequently to protect against an evolving virus population.We have thus developed a processing pipeline and browser-based visualization that allows convenient exploration and analysis of the most recent influenza virus sequence data.

View Article: PubMed Central - PubMed

Affiliation: Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany and.

No MeSH data available.


Related in: MedlinePlus

The frequency diagram allows geography-specific plotting of frequencies of individual mutations, pairs of mutations and clades in the tree
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btv381-F2: The frequency diagram allows geography-specific plotting of frequencies of individual mutations, pairs of mutations and clades in the tree

Mentions: The frequency plot below the tree (Fig. 2) displays the frequency trajectory of clades in the tree whenever the mouse hovers above the branch defining the clade. Furthermore, trajectories of individual mutations, combinations of two mutations and predefined clades such as 3c3.a can be plotted. A second plot shows the variability of the alignment. On mouse-click on a variable position in this plot, auspice will color the tree by amino-acid at this position and plot its mutation frequencies.Fig. 2.


nextflu: real-time tracking of seasonal influenza virus evolution in humans.

Neher RA, Bedford T - Bioinformatics (2015)

The frequency diagram allows geography-specific plotting of frequencies of individual mutations, pairs of mutations and clades in the tree
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4612219&req=5

btv381-F2: The frequency diagram allows geography-specific plotting of frequencies of individual mutations, pairs of mutations and clades in the tree
Mentions: The frequency plot below the tree (Fig. 2) displays the frequency trajectory of clades in the tree whenever the mouse hovers above the branch defining the clade. Furthermore, trajectories of individual mutations, combinations of two mutations and predefined clades such as 3c3.a can be plotted. A second plot shows the variability of the alignment. On mouse-click on a variable position in this plot, auspice will color the tree by amino-acid at this position and plot its mutation frequencies.Fig. 2.

Bottom Line: Seasonal influenza viruses evolve rapidly, allowing them to evade immunity in their human hosts and reinfect previously infected individuals.Similarly, vaccines against seasonal influenza need to be updated frequently to protect against an evolving virus population.We have thus developed a processing pipeline and browser-based visualization that allows convenient exploration and analysis of the most recent influenza virus sequence data.

View Article: PubMed Central - PubMed

Affiliation: Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany and.

No MeSH data available.


Related in: MedlinePlus