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Feasibility of diffusion-weighted magnetic resonance imaging in patients with juvenile idiopathic arthritis on 1.0-T open-bore MRI.

Barendregt AM, Nusman CM, Hemke R, Lavini C, Amiras D, Kuijpers TW, Maas M - Skeletal Radiol. (2015)

Bottom Line: DWI was successfully obtained in all patients.Similar results were obtained when the two observers were analyzed separately (observer 1: p = 0.006, observer 2: p = 0.04).In this pilot study, on a patient-friendly 1.0-T open-bore MRI, we demonstrated that DWI may potentially be a feasible non-invasive imaging technique in children with JIA.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. a.m.barendregt@amc.uva.nl.

ABSTRACT

Objective: To evaluate the feasibility of non-invasive diffusion-weighted imaging (DWI) of the knee of children with juvenile idiopathic arthritis (JIA) and, further, to analyze the apparent diffusion coefficient (ADC) levels to distinguish synovium from effusion.

Materials and methods: Standard magnetic resonance imaging of the knee including post-contrast imaging was obtained in eight patients (mean age, 12 years 8 months, five females) using an open-bore magnetic resonance imaging system (1.0 T). In addition, axially acquired echo-planar DWI datasets (b-values 0, 50, and 600) were prospectively obtained and the diffusion images were post-processed into ADC50-600 maps. Two independent observers selected a region of interest (ROI) for both synovium and effusion using aligned post-contrast images as landmarks. Mann-Whitney U test was performed to compare ADC synovium and ADC effusion.

Results: DWI was successfully obtained in all patients. When data of both observers was combined, ADC synovium was lower than ADC effusion in the ROI in seven out of eight patients (median, 1.92 × 10(-3) mm(2)/s vs. 2.40 × 10(-3) mm(2)/s, p = 0.006, respectively). Similar results were obtained when the two observers were analyzed separately (observer 1: p = 0.006, observer 2: p = 0.04).

Conclusions: In this pilot study, on a patient-friendly 1.0-T open-bore MRI, we demonstrated that DWI may potentially be a feasible non-invasive imaging technique in children with JIA. We could differentiate synovium from effusion in seven out of eight patients based on the ADC of synovium and effusion. However, to select synovium and effusion on DWI, post-contrast images were still a necessity.

No MeSH data available.


Related in: MedlinePlus

Histogram of paired ADC values of synovium per observer
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Fig5: Histogram of paired ADC values of synovium per observer

Mentions: The ADC values of all patients are shown in Table 3. The analysis of the combined ADC values showed that median ADC values of synovium were significantly lower compared to the median ADC values of effusion (1.92 × 10−3 mm2/s vs. 2.40 × 10−3 mm2/s, p = 0.006, respectively). A boxplot of these data is shown in Fig. 3. In the per-observer analysis (Fig. 4), observer 1 had a median synovial ADC of 1.84 × 10−3 mm2/s and a median effusion ADC of 2.48 × 10−3 mm2/s (p = 0.006). For observer 2, these values were 1.96 × 10−3 mm2/s and 2.35 × 10−3 mm2/s, respectively (p = 0.04). In seven out of eight patients, ADC synovium was lower than ADC effusion. This was valid for both the averaged ADC (both observers together) and the separate analysis of the two observers (Figs. 5 and 6).Table 3


Feasibility of diffusion-weighted magnetic resonance imaging in patients with juvenile idiopathic arthritis on 1.0-T open-bore MRI.

Barendregt AM, Nusman CM, Hemke R, Lavini C, Amiras D, Kuijpers TW, Maas M - Skeletal Radiol. (2015)

Histogram of paired ADC values of synovium per observer
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4608988&req=5

Fig5: Histogram of paired ADC values of synovium per observer
Mentions: The ADC values of all patients are shown in Table 3. The analysis of the combined ADC values showed that median ADC values of synovium were significantly lower compared to the median ADC values of effusion (1.92 × 10−3 mm2/s vs. 2.40 × 10−3 mm2/s, p = 0.006, respectively). A boxplot of these data is shown in Fig. 3. In the per-observer analysis (Fig. 4), observer 1 had a median synovial ADC of 1.84 × 10−3 mm2/s and a median effusion ADC of 2.48 × 10−3 mm2/s (p = 0.006). For observer 2, these values were 1.96 × 10−3 mm2/s and 2.35 × 10−3 mm2/s, respectively (p = 0.04). In seven out of eight patients, ADC synovium was lower than ADC effusion. This was valid for both the averaged ADC (both observers together) and the separate analysis of the two observers (Figs. 5 and 6).Table 3

Bottom Line: DWI was successfully obtained in all patients.Similar results were obtained when the two observers were analyzed separately (observer 1: p = 0.006, observer 2: p = 0.04).In this pilot study, on a patient-friendly 1.0-T open-bore MRI, we demonstrated that DWI may potentially be a feasible non-invasive imaging technique in children with JIA.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. a.m.barendregt@amc.uva.nl.

ABSTRACT

Objective: To evaluate the feasibility of non-invasive diffusion-weighted imaging (DWI) of the knee of children with juvenile idiopathic arthritis (JIA) and, further, to analyze the apparent diffusion coefficient (ADC) levels to distinguish synovium from effusion.

Materials and methods: Standard magnetic resonance imaging of the knee including post-contrast imaging was obtained in eight patients (mean age, 12 years 8 months, five females) using an open-bore magnetic resonance imaging system (1.0 T). In addition, axially acquired echo-planar DWI datasets (b-values 0, 50, and 600) were prospectively obtained and the diffusion images were post-processed into ADC50-600 maps. Two independent observers selected a region of interest (ROI) for both synovium and effusion using aligned post-contrast images as landmarks. Mann-Whitney U test was performed to compare ADC synovium and ADC effusion.

Results: DWI was successfully obtained in all patients. When data of both observers was combined, ADC synovium was lower than ADC effusion in the ROI in seven out of eight patients (median, 1.92 × 10(-3) mm(2)/s vs. 2.40 × 10(-3) mm(2)/s, p = 0.006, respectively). Similar results were obtained when the two observers were analyzed separately (observer 1: p = 0.006, observer 2: p = 0.04).

Conclusions: In this pilot study, on a patient-friendly 1.0-T open-bore MRI, we demonstrated that DWI may potentially be a feasible non-invasive imaging technique in children with JIA. We could differentiate synovium from effusion in seven out of eight patients based on the ADC of synovium and effusion. However, to select synovium and effusion on DWI, post-contrast images were still a necessity.

No MeSH data available.


Related in: MedlinePlus