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Effect of Hibiscus sabdariffa extract on high fat diet-induced obesity and liver damage in hamsters.

Huang TW, Chang CL, Kao ES, Lin JH - Food Nutr Res (2015)

Bottom Line: Administration of HSE reduced the levels of liver cholesterol and triglycerides, which were elevated by HFD.Analysis of the effect of HSE on paraoxonase 1, an antioxidant liver enzyme, revealed that HSE potentially regulates lipid peroxides and protects organs from oxidation-associated damage.The markers of liver damage such as serum alanine aminotransferase and aspartate aminotransferase levels that were elevated by HFD were also reduced on HSE treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan.

ABSTRACT

Background: Obesity is a chronic metabolic disorder associated with an increase in adipogenesis and often accompanied with fatty liver disease.

Objective: In this study, we investigated the anti-obesity effects of Hibiscus sabdariffa water extract (HSE) in vivo.

Method: Eight-weeks-old male mice were divided into six groups (n=8 per group) and were fed either normal feed, a high fat diet (HFD), HFD supplemented with different concentrations of HSE, or HFD supplemented with anthocyanin. After 10 weeks of feeding, all the blood and livers were collected for further analysis.

Results: Mesocricetus auratus hamster fed with a high-fat diet developed symptoms of obesity, as determined from their body weight change and from their plasma lipid levels. Meanwhile, HSE treatment reduced fat accumulation in the livers of hamsters fed with HFD in a concentration-dependent manner. Administration of HSE reduced the levels of liver cholesterol and triglycerides, which were elevated by HFD. Analysis of the effect of HSE on paraoxonase 1, an antioxidant liver enzyme, revealed that HSE potentially regulates lipid peroxides and protects organs from oxidation-associated damage. The markers of liver damage such as serum alanine aminotransferase and aspartate aminotransferase levels that were elevated by HFD were also reduced on HSE treatment. The effects of HSE were as effective as treatment with anthocyanin; therefore the anthocyanins present in the HSE may play a crucial role in the protection established against HFD-induced obesity.

Conclusions: In conclusion HSE administration constitutes an effective and viable treatment strategy against the development and consequences of obesity.

No MeSH data available.


Related in: MedlinePlus

Effects of HSE supplement on paraoxonase 1 (PON-1) in HFD-fed hamsters. Serum PON-1 levels in hamsters fed a normal diet (control) and hamsters fed HFD along with different amounts of HSE or 25 mg anthocyanin. Data are shown as the mean±SD: *p<0.05, **p<0.01, ***p<0.001 compared with the HFD group.
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Figure 0003: Effects of HSE supplement on paraoxonase 1 (PON-1) in HFD-fed hamsters. Serum PON-1 levels in hamsters fed a normal diet (control) and hamsters fed HFD along with different amounts of HSE or 25 mg anthocyanin. Data are shown as the mean±SD: *p<0.05, **p<0.01, ***p<0.001 compared with the HFD group.

Mentions: The serum activity levels of PON-1, which is known for its anti-atherosclerotic property, decreased in the HFD-fed hamster groups. However, treatment with various concentrations of HSE increased the PON-1 activity levels in the hamster serum (Fig. 3). Therefore HSE treatment reduced the risk of atherosclerosis associated with HFD feeding.


Effect of Hibiscus sabdariffa extract on high fat diet-induced obesity and liver damage in hamsters.

Huang TW, Chang CL, Kao ES, Lin JH - Food Nutr Res (2015)

Effects of HSE supplement on paraoxonase 1 (PON-1) in HFD-fed hamsters. Serum PON-1 levels in hamsters fed a normal diet (control) and hamsters fed HFD along with different amounts of HSE or 25 mg anthocyanin. Data are shown as the mean±SD: *p<0.05, **p<0.01, ***p<0.001 compared with the HFD group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608971&req=5

Figure 0003: Effects of HSE supplement on paraoxonase 1 (PON-1) in HFD-fed hamsters. Serum PON-1 levels in hamsters fed a normal diet (control) and hamsters fed HFD along with different amounts of HSE or 25 mg anthocyanin. Data are shown as the mean±SD: *p<0.05, **p<0.01, ***p<0.001 compared with the HFD group.
Mentions: The serum activity levels of PON-1, which is known for its anti-atherosclerotic property, decreased in the HFD-fed hamster groups. However, treatment with various concentrations of HSE increased the PON-1 activity levels in the hamster serum (Fig. 3). Therefore HSE treatment reduced the risk of atherosclerosis associated with HFD feeding.

Bottom Line: Administration of HSE reduced the levels of liver cholesterol and triglycerides, which were elevated by HFD.Analysis of the effect of HSE on paraoxonase 1, an antioxidant liver enzyme, revealed that HSE potentially regulates lipid peroxides and protects organs from oxidation-associated damage.The markers of liver damage such as serum alanine aminotransferase and aspartate aminotransferase levels that were elevated by HFD were also reduced on HSE treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan.

ABSTRACT

Background: Obesity is a chronic metabolic disorder associated with an increase in adipogenesis and often accompanied with fatty liver disease.

Objective: In this study, we investigated the anti-obesity effects of Hibiscus sabdariffa water extract (HSE) in vivo.

Method: Eight-weeks-old male mice were divided into six groups (n=8 per group) and were fed either normal feed, a high fat diet (HFD), HFD supplemented with different concentrations of HSE, or HFD supplemented with anthocyanin. After 10 weeks of feeding, all the blood and livers were collected for further analysis.

Results: Mesocricetus auratus hamster fed with a high-fat diet developed symptoms of obesity, as determined from their body weight change and from their plasma lipid levels. Meanwhile, HSE treatment reduced fat accumulation in the livers of hamsters fed with HFD in a concentration-dependent manner. Administration of HSE reduced the levels of liver cholesterol and triglycerides, which were elevated by HFD. Analysis of the effect of HSE on paraoxonase 1, an antioxidant liver enzyme, revealed that HSE potentially regulates lipid peroxides and protects organs from oxidation-associated damage. The markers of liver damage such as serum alanine aminotransferase and aspartate aminotransferase levels that were elevated by HFD were also reduced on HSE treatment. The effects of HSE were as effective as treatment with anthocyanin; therefore the anthocyanins present in the HSE may play a crucial role in the protection established against HFD-induced obesity.

Conclusions: In conclusion HSE administration constitutes an effective and viable treatment strategy against the development and consequences of obesity.

No MeSH data available.


Related in: MedlinePlus