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Antineutrophil cytoplasmic antibody-negative pauci-immune glomerulonephritis with massive intestinal bleeding.

Kim M, Kim YU, Boo SJ, Kim SM, Kim HW - Kidney Res Clin Pract (2015)

Bottom Line: On the 45(th) hospital day, the patient suddenly lost consciousness.Brain computed tomography showed intracerebral hemorrhage.We report a case of antineutrophil cytoplasmic antibody-negative pauci-immune glomerulonephritis with massive intestinal bleeding and cerebral hemorrhage.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology, Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.

ABSTRACT
A 61-year-old woman was admitted to hospital because of generalized edema and proteinuria. Her renal function deteriorated rapidly. Serum immunoglobulin and complement levels were within normal ranges. An autoantibody examination showed negative for antinuclear antibody and antineutrophil cytoplasmic antibody. Histologic examination of a renal biopsy specimen revealed that all of the glomeruli had severe crescent formations with no immune deposits. The patient was treated with steroid pulse therapy with cyclophosphamide followed by oral prednisolone. Fifteen days later, she experienced massive recurrent hematochezia. Angiography revealed an active contrast extravasation in a branch of the distal ileal artery. We selectively embolized with a permanent embolic agent. On the 45(th) hospital day, the patient suddenly lost consciousness. Brain computed tomography showed intracerebral hemorrhage. We report a case of antineutrophil cytoplasmic antibody-negative pauci-immune glomerulonephritis with massive intestinal bleeding and cerebral hemorrhage.

No MeSH data available.


Related in: MedlinePlus

Brain computed tomography scan. Acute intracerebral hemorrhage in the right thalamic-caudate area and intraventricular hemorrhage are shown.
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f0025: Brain computed tomography scan. Acute intracerebral hemorrhage in the right thalamic-caudate area and intraventricular hemorrhage are shown.

Mentions: On the 45th hospital day, she suddenly lost consciousness. Brain computed tomography showed intracerebral hemorrhage (Fig. 5). The patient׳s neurologic status had worsened to a stupor and then, unfortunately, she passed away. The final diagnosis was ANCA-negative pauci-immune GN with a rare presentation of massive gastrointestinal bleeding and intracerebral hemorrhage.


Antineutrophil cytoplasmic antibody-negative pauci-immune glomerulonephritis with massive intestinal bleeding.

Kim M, Kim YU, Boo SJ, Kim SM, Kim HW - Kidney Res Clin Pract (2015)

Brain computed tomography scan. Acute intracerebral hemorrhage in the right thalamic-caudate area and intraventricular hemorrhage are shown.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608877&req=5

f0025: Brain computed tomography scan. Acute intracerebral hemorrhage in the right thalamic-caudate area and intraventricular hemorrhage are shown.
Mentions: On the 45th hospital day, she suddenly lost consciousness. Brain computed tomography showed intracerebral hemorrhage (Fig. 5). The patient׳s neurologic status had worsened to a stupor and then, unfortunately, she passed away. The final diagnosis was ANCA-negative pauci-immune GN with a rare presentation of massive gastrointestinal bleeding and intracerebral hemorrhage.

Bottom Line: On the 45(th) hospital day, the patient suddenly lost consciousness.Brain computed tomography showed intracerebral hemorrhage.We report a case of antineutrophil cytoplasmic antibody-negative pauci-immune glomerulonephritis with massive intestinal bleeding and cerebral hemorrhage.

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology, Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.

ABSTRACT
A 61-year-old woman was admitted to hospital because of generalized edema and proteinuria. Her renal function deteriorated rapidly. Serum immunoglobulin and complement levels were within normal ranges. An autoantibody examination showed negative for antinuclear antibody and antineutrophil cytoplasmic antibody. Histologic examination of a renal biopsy specimen revealed that all of the glomeruli had severe crescent formations with no immune deposits. The patient was treated with steroid pulse therapy with cyclophosphamide followed by oral prednisolone. Fifteen days later, she experienced massive recurrent hematochezia. Angiography revealed an active contrast extravasation in a branch of the distal ileal artery. We selectively embolized with a permanent embolic agent. On the 45(th) hospital day, the patient suddenly lost consciousness. Brain computed tomography showed intracerebral hemorrhage. We report a case of antineutrophil cytoplasmic antibody-negative pauci-immune glomerulonephritis with massive intestinal bleeding and cerebral hemorrhage.

No MeSH data available.


Related in: MedlinePlus