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Organ-on-a-chip and the kidney.

Kim S, Takayama S - Kidney Res Clin Pract (2015)

Bottom Line: Among them, organ-on-a-chip applications allow the fabrication of minimal functional units of a single organ or multiple organs.Relevant to the field of nephrology, renal tubular cells have been integrated with microfluidic devices for making kidneys-on-a-chip.Although still early in development, kidneys-on-a-chip are showing potential to provide a better understanding of the kidney to replace some traditional animal and human studies, particularly as more cell types are incorporated toward the development of a complete glomeruli-on-a-chip.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA ; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

ABSTRACT
Traditional approaches to pathophysiology are advancing but still have many limitations that arise from real biologic systems and their associated physiological phenomena being too complicated. Microfluidics is a novel technology in the field of engineering, which provides new options that may overcome these hurdles. Microfluidics handles small volumes of fluids and may apply to various applications such as DNA analysis chips, other lab-on-a-chip analyses, micropropulsion, and microthermal technologies. Among them, organ-on-a-chip applications allow the fabrication of minimal functional units of a single organ or multiple organs. Relevant to the field of nephrology, renal tubular cells have been integrated with microfluidic devices for making kidneys-on-a-chip. Although still early in development, kidneys-on-a-chip are showing potential to provide a better understanding of the kidney to replace some traditional animal and human studies, particularly as more cell types are incorporated toward the development of a complete glomeruli-on-a-chip.

No MeSH data available.


Related in: MedlinePlus

Simple example of an experiment using organ-on-a-chip.
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f0015: Simple example of an experiment using organ-on-a-chip.

Mentions: As shown in Fig. 3, the whole experimental process using organ-on-a-chip technology consists of several steps. Photolithography, a fabricating technique that can make channels in a microscale, comes from semiconductor technology. It requires labor-intensive work, clean environments, and sophisticated training. An organ-specific microenvironment is a basic platform in the design of these devices. Briefly, researchers design the optimal condition with the proper size, numbers, and compartments of the channels. According to these designs, fine molds are cultivated and the final devices can be made out of transparent and soft polydimethylsiloxane (PDMS) [5]. Sometimes, simple ways to make replicas can be used such as xerographic printing or three-dimensional (3D) printing of molds.


Organ-on-a-chip and the kidney.

Kim S, Takayama S - Kidney Res Clin Pract (2015)

Simple example of an experiment using organ-on-a-chip.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608869&req=5

f0015: Simple example of an experiment using organ-on-a-chip.
Mentions: As shown in Fig. 3, the whole experimental process using organ-on-a-chip technology consists of several steps. Photolithography, a fabricating technique that can make channels in a microscale, comes from semiconductor technology. It requires labor-intensive work, clean environments, and sophisticated training. An organ-specific microenvironment is a basic platform in the design of these devices. Briefly, researchers design the optimal condition with the proper size, numbers, and compartments of the channels. According to these designs, fine molds are cultivated and the final devices can be made out of transparent and soft polydimethylsiloxane (PDMS) [5]. Sometimes, simple ways to make replicas can be used such as xerographic printing or three-dimensional (3D) printing of molds.

Bottom Line: Among them, organ-on-a-chip applications allow the fabrication of minimal functional units of a single organ or multiple organs.Relevant to the field of nephrology, renal tubular cells have been integrated with microfluidic devices for making kidneys-on-a-chip.Although still early in development, kidneys-on-a-chip are showing potential to provide a better understanding of the kidney to replace some traditional animal and human studies, particularly as more cell types are incorporated toward the development of a complete glomeruli-on-a-chip.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA ; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

ABSTRACT
Traditional approaches to pathophysiology are advancing but still have many limitations that arise from real biologic systems and their associated physiological phenomena being too complicated. Microfluidics is a novel technology in the field of engineering, which provides new options that may overcome these hurdles. Microfluidics handles small volumes of fluids and may apply to various applications such as DNA analysis chips, other lab-on-a-chip analyses, micropropulsion, and microthermal technologies. Among them, organ-on-a-chip applications allow the fabrication of minimal functional units of a single organ or multiple organs. Relevant to the field of nephrology, renal tubular cells have been integrated with microfluidic devices for making kidneys-on-a-chip. Although still early in development, kidneys-on-a-chip are showing potential to provide a better understanding of the kidney to replace some traditional animal and human studies, particularly as more cell types are incorporated toward the development of a complete glomeruli-on-a-chip.

No MeSH data available.


Related in: MedlinePlus