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Organ-on-a-chip and the kidney.

Kim S, Takayama S - Kidney Res Clin Pract (2015)

Bottom Line: Among them, organ-on-a-chip applications allow the fabrication of minimal functional units of a single organ or multiple organs.Relevant to the field of nephrology, renal tubular cells have been integrated with microfluidic devices for making kidneys-on-a-chip.Although still early in development, kidneys-on-a-chip are showing potential to provide a better understanding of the kidney to replace some traditional animal and human studies, particularly as more cell types are incorporated toward the development of a complete glomeruli-on-a-chip.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA ; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

ABSTRACT
Traditional approaches to pathophysiology are advancing but still have many limitations that arise from real biologic systems and their associated physiological phenomena being too complicated. Microfluidics is a novel technology in the field of engineering, which provides new options that may overcome these hurdles. Microfluidics handles small volumes of fluids and may apply to various applications such as DNA analysis chips, other lab-on-a-chip analyses, micropropulsion, and microthermal technologies. Among them, organ-on-a-chip applications allow the fabrication of minimal functional units of a single organ or multiple organs. Relevant to the field of nephrology, renal tubular cells have been integrated with microfluidic devices for making kidneys-on-a-chip. Although still early in development, kidneys-on-a-chip are showing potential to provide a better understanding of the kidney to replace some traditional animal and human studies, particularly as more cell types are incorporated toward the development of a complete glomeruli-on-a-chip.

No MeSH data available.


Related in: MedlinePlus

Concepts of organs-on-a-chip. PDMS, polydimethylsiloxane.
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f0010: Concepts of organs-on-a-chip. PDMS, polydimethylsiloxane.

Mentions: Organ-on-a-chip is a microfluidic cell culture device that is a more physiologically relevant in vitro model than cells cultured in dishes. Important features include continuously perfused chambers inhabited by living cells arranged to simulate tissue- and organ-level physiology [5] (Fig. 2). So far, several individual organ-on-chips have been developed, including gut-on-a-chip [6], lung-on-a-chip [7], blood vessel-on-a-chip [8], cancer-on-a-chip [9], bone marrow-on-a-chip [10], and kidney-on-a-chip [11]. In addition, multiple organs-on-a-chip has been tried, such as liver-tumor-bone marrow-on-a-chip [12] or liver-skin-intestine-kidney-on-a-chip [13].


Organ-on-a-chip and the kidney.

Kim S, Takayama S - Kidney Res Clin Pract (2015)

Concepts of organs-on-a-chip. PDMS, polydimethylsiloxane.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608869&req=5

f0010: Concepts of organs-on-a-chip. PDMS, polydimethylsiloxane.
Mentions: Organ-on-a-chip is a microfluidic cell culture device that is a more physiologically relevant in vitro model than cells cultured in dishes. Important features include continuously perfused chambers inhabited by living cells arranged to simulate tissue- and organ-level physiology [5] (Fig. 2). So far, several individual organ-on-chips have been developed, including gut-on-a-chip [6], lung-on-a-chip [7], blood vessel-on-a-chip [8], cancer-on-a-chip [9], bone marrow-on-a-chip [10], and kidney-on-a-chip [11]. In addition, multiple organs-on-a-chip has been tried, such as liver-tumor-bone marrow-on-a-chip [12] or liver-skin-intestine-kidney-on-a-chip [13].

Bottom Line: Among them, organ-on-a-chip applications allow the fabrication of minimal functional units of a single organ or multiple organs.Relevant to the field of nephrology, renal tubular cells have been integrated with microfluidic devices for making kidneys-on-a-chip.Although still early in development, kidneys-on-a-chip are showing potential to provide a better understanding of the kidney to replace some traditional animal and human studies, particularly as more cell types are incorporated toward the development of a complete glomeruli-on-a-chip.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA ; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

ABSTRACT
Traditional approaches to pathophysiology are advancing but still have many limitations that arise from real biologic systems and their associated physiological phenomena being too complicated. Microfluidics is a novel technology in the field of engineering, which provides new options that may overcome these hurdles. Microfluidics handles small volumes of fluids and may apply to various applications such as DNA analysis chips, other lab-on-a-chip analyses, micropropulsion, and microthermal technologies. Among them, organ-on-a-chip applications allow the fabrication of minimal functional units of a single organ or multiple organs. Relevant to the field of nephrology, renal tubular cells have been integrated with microfluidic devices for making kidneys-on-a-chip. Although still early in development, kidneys-on-a-chip are showing potential to provide a better understanding of the kidney to replace some traditional animal and human studies, particularly as more cell types are incorporated toward the development of a complete glomeruli-on-a-chip.

No MeSH data available.


Related in: MedlinePlus