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Organ-on-a-chip and the kidney.

Kim S, Takayama S - Kidney Res Clin Pract (2015)

Bottom Line: Among them, organ-on-a-chip applications allow the fabrication of minimal functional units of a single organ or multiple organs.Relevant to the field of nephrology, renal tubular cells have been integrated with microfluidic devices for making kidneys-on-a-chip.Although still early in development, kidneys-on-a-chip are showing potential to provide a better understanding of the kidney to replace some traditional animal and human studies, particularly as more cell types are incorporated toward the development of a complete glomeruli-on-a-chip.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA ; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

ABSTRACT
Traditional approaches to pathophysiology are advancing but still have many limitations that arise from real biologic systems and their associated physiological phenomena being too complicated. Microfluidics is a novel technology in the field of engineering, which provides new options that may overcome these hurdles. Microfluidics handles small volumes of fluids and may apply to various applications such as DNA analysis chips, other lab-on-a-chip analyses, micropropulsion, and microthermal technologies. Among them, organ-on-a-chip applications allow the fabrication of minimal functional units of a single organ or multiple organs. Relevant to the field of nephrology, renal tubular cells have been integrated with microfluidic devices for making kidneys-on-a-chip. Although still early in development, kidneys-on-a-chip are showing potential to provide a better understanding of the kidney to replace some traditional animal and human studies, particularly as more cell types are incorporated toward the development of a complete glomeruli-on-a-chip.

No MeSH data available.


Related in: MedlinePlus

Concepts of microfluidics.
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f0005: Concepts of microfluidics.

Mentions: Microfluidics is characterized by the engineered manipulation of fluids at the submillimeter scale [2]. The microscale devices in microfluidics are commonly referred to as miniaturized total analysis systems or lab-on-a-chip technologies [2]. In the 1990s to 2000s, microfluidics focused on the miniaturization of previously macroscale assays. Within several years, various new technologies showed better performances than the traditional methods. For example, there are paper-based analytical devices for diagnostics [3], immunoassays assisted by surface tension [4], and organ-on-a-chip technologies [2,5] (Fig. 1). We will further focus on organs-on-chips.


Organ-on-a-chip and the kidney.

Kim S, Takayama S - Kidney Res Clin Pract (2015)

Concepts of microfluidics.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608869&req=5

f0005: Concepts of microfluidics.
Mentions: Microfluidics is characterized by the engineered manipulation of fluids at the submillimeter scale [2]. The microscale devices in microfluidics are commonly referred to as miniaturized total analysis systems or lab-on-a-chip technologies [2]. In the 1990s to 2000s, microfluidics focused on the miniaturization of previously macroscale assays. Within several years, various new technologies showed better performances than the traditional methods. For example, there are paper-based analytical devices for diagnostics [3], immunoassays assisted by surface tension [4], and organ-on-a-chip technologies [2,5] (Fig. 1). We will further focus on organs-on-chips.

Bottom Line: Among them, organ-on-a-chip applications allow the fabrication of minimal functional units of a single organ or multiple organs.Relevant to the field of nephrology, renal tubular cells have been integrated with microfluidic devices for making kidneys-on-a-chip.Although still early in development, kidneys-on-a-chip are showing potential to provide a better understanding of the kidney to replace some traditional animal and human studies, particularly as more cell types are incorporated toward the development of a complete glomeruli-on-a-chip.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA ; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

ABSTRACT
Traditional approaches to pathophysiology are advancing but still have many limitations that arise from real biologic systems and their associated physiological phenomena being too complicated. Microfluidics is a novel technology in the field of engineering, which provides new options that may overcome these hurdles. Microfluidics handles small volumes of fluids and may apply to various applications such as DNA analysis chips, other lab-on-a-chip analyses, micropropulsion, and microthermal technologies. Among them, organ-on-a-chip applications allow the fabrication of minimal functional units of a single organ or multiple organs. Relevant to the field of nephrology, renal tubular cells have been integrated with microfluidic devices for making kidneys-on-a-chip. Although still early in development, kidneys-on-a-chip are showing potential to provide a better understanding of the kidney to replace some traditional animal and human studies, particularly as more cell types are incorporated toward the development of a complete glomeruli-on-a-chip.

No MeSH data available.


Related in: MedlinePlus