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Meta-Analysis: Effects of Probiotic Supplementation on Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals.

Shimizu M, Hashiguchi M, Shiga T, Tamura HO, Mochizuki M - PLoS ONE (2015)

Bottom Line: However, there are conflicting results on the efficacy of probiotic preparations in reducing serum cholesterol.High-density lipoprotein cholesterol and triglyceride levels did not differ significantly between probiotic and control groups.The decreases in TC and LDL-C levels with probiotic intervention were greater in mildly hypercholesterolemic than in normocholesterolemic individuals.

View Article: PubMed Central - PubMed

Affiliation: Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-50-30 Shibakoen, Tokyo, 105-8512, Japan.

ABSTRACT

Introduction: Recent experimental and clinical studies have suggested that probiotic supplementation has beneficial effects on serum lipid profiles. However, there are conflicting results on the efficacy of probiotic preparations in reducing serum cholesterol.

Objective: To evaluate the effects of probiotics on human serum lipid levels, we conducted a meta-analysis of interventional studies.

Methods: Eligible reports were obtained by searches of electronic databases. We included randomized, controlled clinical trials comparing probiotic supplementation with placebo or no treatment (control). Statistical analysis was performed with Review Manager 5.3.3. Subanalyses were also performed.

Results: Eleven of 33 randomized clinical trials retrieved were eligible for inclusion in the meta-analysis. No participant had received any cholesterol-lowering agent. Probiotic interventions (including fermented milk products and probiotics) produced changes in total cholesterol (TC) (mean difference -0.17 mmol/L, 95% CI: -0.27 to -0.07 mmol/L) and low-density lipoprotein cholesterol (LDL-C) (mean difference -0.22 mmol/L, 95% CI: -0.30 to -0.13 mmol/L). High-density lipoprotein cholesterol and triglyceride levels did not differ significantly between probiotic and control groups. In subanalysis, long-term (> 4-week) probiotic intervention was statistically more effective in decreasing TC and LDL-C than short-term (≤ 4-week) intervention. The decreases in TC and LDL-C levels with probiotic intervention were greater in mildly hypercholesterolemic than in normocholesterolemic individuals. Both fermented milk product and probiotic preparations decreased TC and LDL-C levels. Gaio and the Lactobacillus acidophilus strain reduced TC and LDL-C levels to a greater extent than other bacterial strains.

Conclusions: In conclusion, this meta-analysis showed that probiotic supplementation could be useful in the primary prevention of hypercholesterolemia and may lead to reductions in risk factors for cardiovascular disease.

No MeSH data available.


Related in: MedlinePlus

Funnel plots for the results of the 11 articles in the mean difference in the change in the intervention group (I) minus the change in the control group (C) in TC.
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pone.0139795.g006: Funnel plots for the results of the 11 articles in the mean difference in the change in the intervention group (I) minus the change in the control group (C) in TC.

Mentions: The funnel plots for the results of the 11 articles on TC and 9 articles on LDL-C in terms of the mean change in the intervention group (I) minus the change in the control group (C) in TC and LDL-C are shown in Figs 6 and 7, respectively. The results of Begg’s rank correlation method suggested no statistically significant asymmetry in funnel plots for TC and LDL-C analyses, indicating no evidence of substantial publication bias. However, the results of the Egger weighted regression method suggested a statistically significant asymmetry in funnel plots for TC analysis.


Meta-Analysis: Effects of Probiotic Supplementation on Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals.

Shimizu M, Hashiguchi M, Shiga T, Tamura HO, Mochizuki M - PLoS ONE (2015)

Funnel plots for the results of the 11 articles in the mean difference in the change in the intervention group (I) minus the change in the control group (C) in TC.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608827&req=5

pone.0139795.g006: Funnel plots for the results of the 11 articles in the mean difference in the change in the intervention group (I) minus the change in the control group (C) in TC.
Mentions: The funnel plots for the results of the 11 articles on TC and 9 articles on LDL-C in terms of the mean change in the intervention group (I) minus the change in the control group (C) in TC and LDL-C are shown in Figs 6 and 7, respectively. The results of Begg’s rank correlation method suggested no statistically significant asymmetry in funnel plots for TC and LDL-C analyses, indicating no evidence of substantial publication bias. However, the results of the Egger weighted regression method suggested a statistically significant asymmetry in funnel plots for TC analysis.

Bottom Line: However, there are conflicting results on the efficacy of probiotic preparations in reducing serum cholesterol.High-density lipoprotein cholesterol and triglyceride levels did not differ significantly between probiotic and control groups.The decreases in TC and LDL-C levels with probiotic intervention were greater in mildly hypercholesterolemic than in normocholesterolemic individuals.

View Article: PubMed Central - PubMed

Affiliation: Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-50-30 Shibakoen, Tokyo, 105-8512, Japan.

ABSTRACT

Introduction: Recent experimental and clinical studies have suggested that probiotic supplementation has beneficial effects on serum lipid profiles. However, there are conflicting results on the efficacy of probiotic preparations in reducing serum cholesterol.

Objective: To evaluate the effects of probiotics on human serum lipid levels, we conducted a meta-analysis of interventional studies.

Methods: Eligible reports were obtained by searches of electronic databases. We included randomized, controlled clinical trials comparing probiotic supplementation with placebo or no treatment (control). Statistical analysis was performed with Review Manager 5.3.3. Subanalyses were also performed.

Results: Eleven of 33 randomized clinical trials retrieved were eligible for inclusion in the meta-analysis. No participant had received any cholesterol-lowering agent. Probiotic interventions (including fermented milk products and probiotics) produced changes in total cholesterol (TC) (mean difference -0.17 mmol/L, 95% CI: -0.27 to -0.07 mmol/L) and low-density lipoprotein cholesterol (LDL-C) (mean difference -0.22 mmol/L, 95% CI: -0.30 to -0.13 mmol/L). High-density lipoprotein cholesterol and triglyceride levels did not differ significantly between probiotic and control groups. In subanalysis, long-term (> 4-week) probiotic intervention was statistically more effective in decreasing TC and LDL-C than short-term (≤ 4-week) intervention. The decreases in TC and LDL-C levels with probiotic intervention were greater in mildly hypercholesterolemic than in normocholesterolemic individuals. Both fermented milk product and probiotic preparations decreased TC and LDL-C levels. Gaio and the Lactobacillus acidophilus strain reduced TC and LDL-C levels to a greater extent than other bacterial strains.

Conclusions: In conclusion, this meta-analysis showed that probiotic supplementation could be useful in the primary prevention of hypercholesterolemia and may lead to reductions in risk factors for cardiovascular disease.

No MeSH data available.


Related in: MedlinePlus