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Meta-Analysis: Effects of Probiotic Supplementation on Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals.

Shimizu M, Hashiguchi M, Shiga T, Tamura HO, Mochizuki M - PLoS ONE (2015)

Bottom Line: However, there are conflicting results on the efficacy of probiotic preparations in reducing serum cholesterol.High-density lipoprotein cholesterol and triglyceride levels did not differ significantly between probiotic and control groups.The decreases in TC and LDL-C levels with probiotic intervention were greater in mildly hypercholesterolemic than in normocholesterolemic individuals.

View Article: PubMed Central - PubMed

Affiliation: Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-50-30 Shibakoen, Tokyo, 105-8512, Japan.

ABSTRACT

Introduction: Recent experimental and clinical studies have suggested that probiotic supplementation has beneficial effects on serum lipid profiles. However, there are conflicting results on the efficacy of probiotic preparations in reducing serum cholesterol.

Objective: To evaluate the effects of probiotics on human serum lipid levels, we conducted a meta-analysis of interventional studies.

Methods: Eligible reports were obtained by searches of electronic databases. We included randomized, controlled clinical trials comparing probiotic supplementation with placebo or no treatment (control). Statistical analysis was performed with Review Manager 5.3.3. Subanalyses were also performed.

Results: Eleven of 33 randomized clinical trials retrieved were eligible for inclusion in the meta-analysis. No participant had received any cholesterol-lowering agent. Probiotic interventions (including fermented milk products and probiotics) produced changes in total cholesterol (TC) (mean difference -0.17 mmol/L, 95% CI: -0.27 to -0.07 mmol/L) and low-density lipoprotein cholesterol (LDL-C) (mean difference -0.22 mmol/L, 95% CI: -0.30 to -0.13 mmol/L). High-density lipoprotein cholesterol and triglyceride levels did not differ significantly between probiotic and control groups. In subanalysis, long-term (> 4-week) probiotic intervention was statistically more effective in decreasing TC and LDL-C than short-term (≤ 4-week) intervention. The decreases in TC and LDL-C levels with probiotic intervention were greater in mildly hypercholesterolemic than in normocholesterolemic individuals. Both fermented milk product and probiotic preparations decreased TC and LDL-C levels. Gaio and the Lactobacillus acidophilus strain reduced TC and LDL-C levels to a greater extent than other bacterial strains.

Conclusions: In conclusion, this meta-analysis showed that probiotic supplementation could be useful in the primary prevention of hypercholesterolemia and may lead to reductions in risk factors for cardiovascular disease.

No MeSH data available.


Related in: MedlinePlus

Effects of probiotics on changes in serum HDL-C levels.Values in parentheses indicate intake duration (weeks). a, b, and c in parentheses indicate Gaio, Stra, and StLa vs PP, respectively; d, e, and f in parentheses indicate Gaio, Stra, and StLa vs PY, respectively. PP: placebo pill; PY: placebo yogurt; StLa: Streptococcus thermophilus and Lactobacillus acidophilus; StLr: Streptococcus thermophilus and Lactobacillus rhamnosus.
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pone.0139795.g004: Effects of probiotics on changes in serum HDL-C levels.Values in parentheses indicate intake duration (weeks). a, b, and c in parentheses indicate Gaio, Stra, and StLa vs PP, respectively; d, e, and f in parentheses indicate Gaio, Stra, and StLa vs PY, respectively. PP: placebo pill; PY: placebo yogurt; StLa: Streptococcus thermophilus and Lactobacillus acidophilus; StLr: Streptococcus thermophilus and Lactobacillus rhamnosus.

Mentions: Nine articles (including 22 studies) that described the changes (I–C) in HDL-C were selected for the meta-analysis. The mean difference in HDL-C was 0.01 mmol/L (95% CI: –0.02 to 0.03 mmol/L; P = 0.59) in the fixed-effect analysis (Fig 4). Similarly, eight articles (based on 20 studies) that detailed the changes (I–C) in TG levels were subjected to meta-analysis, and the mean difference in TG levels was 0.01 mmol/L (95% CI: –0.08 to 0.09 mmol/L; P = 0.89) in the fixed-effect analysis (Fig 5). These data show that HDL-C and TG levels did not differ significantly between the probiotic intervention and control groups.


Meta-Analysis: Effects of Probiotic Supplementation on Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals.

Shimizu M, Hashiguchi M, Shiga T, Tamura HO, Mochizuki M - PLoS ONE (2015)

Effects of probiotics on changes in serum HDL-C levels.Values in parentheses indicate intake duration (weeks). a, b, and c in parentheses indicate Gaio, Stra, and StLa vs PP, respectively; d, e, and f in parentheses indicate Gaio, Stra, and StLa vs PY, respectively. PP: placebo pill; PY: placebo yogurt; StLa: Streptococcus thermophilus and Lactobacillus acidophilus; StLr: Streptococcus thermophilus and Lactobacillus rhamnosus.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608827&req=5

pone.0139795.g004: Effects of probiotics on changes in serum HDL-C levels.Values in parentheses indicate intake duration (weeks). a, b, and c in parentheses indicate Gaio, Stra, and StLa vs PP, respectively; d, e, and f in parentheses indicate Gaio, Stra, and StLa vs PY, respectively. PP: placebo pill; PY: placebo yogurt; StLa: Streptococcus thermophilus and Lactobacillus acidophilus; StLr: Streptococcus thermophilus and Lactobacillus rhamnosus.
Mentions: Nine articles (including 22 studies) that described the changes (I–C) in HDL-C were selected for the meta-analysis. The mean difference in HDL-C was 0.01 mmol/L (95% CI: –0.02 to 0.03 mmol/L; P = 0.59) in the fixed-effect analysis (Fig 4). Similarly, eight articles (based on 20 studies) that detailed the changes (I–C) in TG levels were subjected to meta-analysis, and the mean difference in TG levels was 0.01 mmol/L (95% CI: –0.08 to 0.09 mmol/L; P = 0.89) in the fixed-effect analysis (Fig 5). These data show that HDL-C and TG levels did not differ significantly between the probiotic intervention and control groups.

Bottom Line: However, there are conflicting results on the efficacy of probiotic preparations in reducing serum cholesterol.High-density lipoprotein cholesterol and triglyceride levels did not differ significantly between probiotic and control groups.The decreases in TC and LDL-C levels with probiotic intervention were greater in mildly hypercholesterolemic than in normocholesterolemic individuals.

View Article: PubMed Central - PubMed

Affiliation: Department of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-50-30 Shibakoen, Tokyo, 105-8512, Japan.

ABSTRACT

Introduction: Recent experimental and clinical studies have suggested that probiotic supplementation has beneficial effects on serum lipid profiles. However, there are conflicting results on the efficacy of probiotic preparations in reducing serum cholesterol.

Objective: To evaluate the effects of probiotics on human serum lipid levels, we conducted a meta-analysis of interventional studies.

Methods: Eligible reports were obtained by searches of electronic databases. We included randomized, controlled clinical trials comparing probiotic supplementation with placebo or no treatment (control). Statistical analysis was performed with Review Manager 5.3.3. Subanalyses were also performed.

Results: Eleven of 33 randomized clinical trials retrieved were eligible for inclusion in the meta-analysis. No participant had received any cholesterol-lowering agent. Probiotic interventions (including fermented milk products and probiotics) produced changes in total cholesterol (TC) (mean difference -0.17 mmol/L, 95% CI: -0.27 to -0.07 mmol/L) and low-density lipoprotein cholesterol (LDL-C) (mean difference -0.22 mmol/L, 95% CI: -0.30 to -0.13 mmol/L). High-density lipoprotein cholesterol and triglyceride levels did not differ significantly between probiotic and control groups. In subanalysis, long-term (> 4-week) probiotic intervention was statistically more effective in decreasing TC and LDL-C than short-term (≤ 4-week) intervention. The decreases in TC and LDL-C levels with probiotic intervention were greater in mildly hypercholesterolemic than in normocholesterolemic individuals. Both fermented milk product and probiotic preparations decreased TC and LDL-C levels. Gaio and the Lactobacillus acidophilus strain reduced TC and LDL-C levels to a greater extent than other bacterial strains.

Conclusions: In conclusion, this meta-analysis showed that probiotic supplementation could be useful in the primary prevention of hypercholesterolemia and may lead to reductions in risk factors for cardiovascular disease.

No MeSH data available.


Related in: MedlinePlus