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Serological Evidence of Chikungunya Virus among Acute Febrile Patients in Southern Mozambique.

Gudo ES, Pinto G, Vene S, Mandlaze A, Muianga AF, Cliff J, Falk K - PLoS Negl Trop Dis (2015)

Bottom Line: Seroconversion or a four-fold titer rise was confirmed in 9 (4.3%) patients.The results of this study strongly suggest that CHIKV is circulating in southern Mozambique.We recommend that CHIKV should be considered in the differential diagnosis of acute febrile illness in Mozambique and that systematic surveillance for CHIKV should be implemented.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Health, Ministry of Health, Maputo, Mozambique.

ABSTRACT

Background: In the last two decades, chikungunya virus (CHIKV) has rapidly expanded to several geographical areas, causing frequent outbreaks in sub-Saharan Africa, South East Asia, South America, and Europe. Therefore, the disease remains heavily neglected in Mozambique, and no recent study has been conducted.

Methods: Between January and September 2013, acute febrile patients with no other evident cause of fever and attending a health center in a suburban area of Maputo city, Mozambique, were consecutively invited to participate. Paired acute and convalescent serum samples were requested from each participant. Convalescent samples were initially screened for anti-CHIKV IgG using a commercial indirect immunofluorescence test, and if positive, the corresponding acute sample was screened using the same test.

Results: Four hundred patients were enrolled. The median age of study participants was 26 years (IQR: 21-33 years) and 57.5% (224/391) were female. Paired blood samples were obtained from 209 patients, of which 26.4% (55/208) were presented anti-CHIKV IgG antibodies in the convalescent sample. Seroconversion or a four-fold titer rise was confirmed in 9 (4.3%) patients.

Conclusion: The results of this study strongly suggest that CHIKV is circulating in southern Mozambique. We recommend that CHIKV should be considered in the differential diagnosis of acute febrile illness in Mozambique and that systematic surveillance for CHIKV should be implemented.

No MeSH data available.


Related in: MedlinePlus

Geographical representation of study area.Left panel shows the geographical localization of Mozambique in south east Africa (Mozambique is highlighted in pink) and map of Mozambique. Right panel is the representation of the neighborhood of Mavalane health area covered by the Mavalane health center. Mavalane health area comprises two geographical and well delimited areas, namely, Mavalane “A” (dark blue) and Mavalane “B” (pink) neighborhood.
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pntd.0004146.g001: Geographical representation of study area.Left panel shows the geographical localization of Mozambique in south east Africa (Mozambique is highlighted in pink) and map of Mozambique. Right panel is the representation of the neighborhood of Mavalane health area covered by the Mavalane health center. Mavalane health area comprises two geographical and well delimited areas, namely, Mavalane “A” (dark blue) and Mavalane “B” (pink) neighborhood.

Mentions: This study was conducted at the Mavalane Health Center, a primary health care facility located in a large suburban area in Maputo City in southern Mozambique (see Fig 1). The study area is characterized by poverty, poor sanitation, and an extremely high population density. The prevalence of malaria is high in this setting. The main sources of income are from the informal sector and small business. The rainy season extends from November through March.


Serological Evidence of Chikungunya Virus among Acute Febrile Patients in Southern Mozambique.

Gudo ES, Pinto G, Vene S, Mandlaze A, Muianga AF, Cliff J, Falk K - PLoS Negl Trop Dis (2015)

Geographical representation of study area.Left panel shows the geographical localization of Mozambique in south east Africa (Mozambique is highlighted in pink) and map of Mozambique. Right panel is the representation of the neighborhood of Mavalane health area covered by the Mavalane health center. Mavalane health area comprises two geographical and well delimited areas, namely, Mavalane “A” (dark blue) and Mavalane “B” (pink) neighborhood.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608817&req=5

pntd.0004146.g001: Geographical representation of study area.Left panel shows the geographical localization of Mozambique in south east Africa (Mozambique is highlighted in pink) and map of Mozambique. Right panel is the representation of the neighborhood of Mavalane health area covered by the Mavalane health center. Mavalane health area comprises two geographical and well delimited areas, namely, Mavalane “A” (dark blue) and Mavalane “B” (pink) neighborhood.
Mentions: This study was conducted at the Mavalane Health Center, a primary health care facility located in a large suburban area in Maputo City in southern Mozambique (see Fig 1). The study area is characterized by poverty, poor sanitation, and an extremely high population density. The prevalence of malaria is high in this setting. The main sources of income are from the informal sector and small business. The rainy season extends from November through March.

Bottom Line: Seroconversion or a four-fold titer rise was confirmed in 9 (4.3%) patients.The results of this study strongly suggest that CHIKV is circulating in southern Mozambique.We recommend that CHIKV should be considered in the differential diagnosis of acute febrile illness in Mozambique and that systematic surveillance for CHIKV should be implemented.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Health, Ministry of Health, Maputo, Mozambique.

ABSTRACT

Background: In the last two decades, chikungunya virus (CHIKV) has rapidly expanded to several geographical areas, causing frequent outbreaks in sub-Saharan Africa, South East Asia, South America, and Europe. Therefore, the disease remains heavily neglected in Mozambique, and no recent study has been conducted.

Methods: Between January and September 2013, acute febrile patients with no other evident cause of fever and attending a health center in a suburban area of Maputo city, Mozambique, were consecutively invited to participate. Paired acute and convalescent serum samples were requested from each participant. Convalescent samples were initially screened for anti-CHIKV IgG using a commercial indirect immunofluorescence test, and if positive, the corresponding acute sample was screened using the same test.

Results: Four hundred patients were enrolled. The median age of study participants was 26 years (IQR: 21-33 years) and 57.5% (224/391) were female. Paired blood samples were obtained from 209 patients, of which 26.4% (55/208) were presented anti-CHIKV IgG antibodies in the convalescent sample. Seroconversion or a four-fold titer rise was confirmed in 9 (4.3%) patients.

Conclusion: The results of this study strongly suggest that CHIKV is circulating in southern Mozambique. We recommend that CHIKV should be considered in the differential diagnosis of acute febrile illness in Mozambique and that systematic surveillance for CHIKV should be implemented.

No MeSH data available.


Related in: MedlinePlus