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Predictors of Persistent Anaemia in the First Year of Antiretroviral Therapy: A Retrospective Cohort Study from Goma, the Democratic Republic of Congo.

Akilimali PZ, Kashala-Abotnes E, Musumari PM, Kayembe PK, Tylleskar T, Mapatano MA - PLoS ONE (2015)

Bottom Line: Haemoglobin concentrations of all patients on ART regimen were obtained prior to and within one year of ART initiation.Patients who received zidovudine (AZT) gained less than those who did not receive AZT (0.99 g/dl vs 1.33 g/dl; p< 0.001).The AZT-containing regimen and absence of cotrimoxazole prophylaxis before starting ART were associated with persistent anaemia 12 months, after initiation of treatment.

View Article: PubMed Central - PubMed

Affiliation: Kinshasa University School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of Congo.

ABSTRACT

Background: Anaemia is associated with adverse outcomes including early death in the first year of antiretroviral therapy (ART). This study reports on the factors associated with persistent anaemia among HIV-infected patients initiating ART in the Democratic Republic of Congo (DR Congo).

Methods: We conducted a retrospective cohort study and analyzed data from patients receiving HIV care between January 2004 and December 2012 at two major hospitals in Goma, DR Congo. Haemoglobin concentrations of all patients on ART regimen were obtained prior to and within one year of ART initiation. A logistic regression model was used to identify the predictors of persistent anaemia after 12 months of ART.

Results: Of 756 patients, 69% of patients were anaemic (IC95%: 65.7-72.3) at baseline. After 12 months of follow up, there was a 1.2 g/dl average increase of haemoglobin concentration (P < 0.001) with differences depending on the therapeutic regimen. Patients who received zidovudine (AZT) gained less than those who did not receive AZT (0.99 g/dl vs 1.33 g/dl; p< 0.001). Among 445 patient who had anaemia at the beginning, 33% (147/445) had the condition resolved. Among patients with anaemia at ART initiation, those who did not receive cotrimoxazole prophylaxis before starting ART(AOR 3.89; 95% CI 2.09-7.25; P < 0.001) and a AZT initial regimen (AOR 2.19; 95% CI 1.36-3.52; P < 0.001) were significantly at risk of persistent anaemia.

Conclusions: More than two thirds of patients had anaemia at baseline. The AZT-containing regimen and absence of cotrimoxazole prophylaxis before starting ART were associated with persistent anaemia 12 months, after initiation of treatment. Considering the large proportion of patients with persistence of anaemia at 12 months, we suggest that it is necessary to conduct a large study to assess anaemia among HIV-infected patients in Goma.

No MeSH data available.


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Study flow of participants in two different HIV treatment centers at Goma, in the Democratic Republic of Congo.
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pone.0140240.g001: Study flow of participants in two different HIV treatment centers at Goma, in the Democratic Republic of Congo.

Mentions: A total of 844 HIV patients were enrolled in the HIV program between January 1, 2004, and December 15, 2012. We excluded those who had not yet been on ART for 12 months (79 patients) and those with missing Hb values at enrolment (88 patients). Overall, the excluded patients were similar to those who were kept in the analysis in terms of age (mean 39.51± 9.79 years) and gender (63.9% female) distributions. Among 445 patients who had anaemia at the beginning, 33% (147/445) had resolution of anaemia (See Fig 1).


Predictors of Persistent Anaemia in the First Year of Antiretroviral Therapy: A Retrospective Cohort Study from Goma, the Democratic Republic of Congo.

Akilimali PZ, Kashala-Abotnes E, Musumari PM, Kayembe PK, Tylleskar T, Mapatano MA - PLoS ONE (2015)

Study flow of participants in two different HIV treatment centers at Goma, in the Democratic Republic of Congo.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608787&req=5

pone.0140240.g001: Study flow of participants in two different HIV treatment centers at Goma, in the Democratic Republic of Congo.
Mentions: A total of 844 HIV patients were enrolled in the HIV program between January 1, 2004, and December 15, 2012. We excluded those who had not yet been on ART for 12 months (79 patients) and those with missing Hb values at enrolment (88 patients). Overall, the excluded patients were similar to those who were kept in the analysis in terms of age (mean 39.51± 9.79 years) and gender (63.9% female) distributions. Among 445 patients who had anaemia at the beginning, 33% (147/445) had resolution of anaemia (See Fig 1).

Bottom Line: Haemoglobin concentrations of all patients on ART regimen were obtained prior to and within one year of ART initiation.Patients who received zidovudine (AZT) gained less than those who did not receive AZT (0.99 g/dl vs 1.33 g/dl; p< 0.001).The AZT-containing regimen and absence of cotrimoxazole prophylaxis before starting ART were associated with persistent anaemia 12 months, after initiation of treatment.

View Article: PubMed Central - PubMed

Affiliation: Kinshasa University School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of Congo.

ABSTRACT

Background: Anaemia is associated with adverse outcomes including early death in the first year of antiretroviral therapy (ART). This study reports on the factors associated with persistent anaemia among HIV-infected patients initiating ART in the Democratic Republic of Congo (DR Congo).

Methods: We conducted a retrospective cohort study and analyzed data from patients receiving HIV care between January 2004 and December 2012 at two major hospitals in Goma, DR Congo. Haemoglobin concentrations of all patients on ART regimen were obtained prior to and within one year of ART initiation. A logistic regression model was used to identify the predictors of persistent anaemia after 12 months of ART.

Results: Of 756 patients, 69% of patients were anaemic (IC95%: 65.7-72.3) at baseline. After 12 months of follow up, there was a 1.2 g/dl average increase of haemoglobin concentration (P < 0.001) with differences depending on the therapeutic regimen. Patients who received zidovudine (AZT) gained less than those who did not receive AZT (0.99 g/dl vs 1.33 g/dl; p< 0.001). Among 445 patient who had anaemia at the beginning, 33% (147/445) had the condition resolved. Among patients with anaemia at ART initiation, those who did not receive cotrimoxazole prophylaxis before starting ART(AOR 3.89; 95% CI 2.09-7.25; P < 0.001) and a AZT initial regimen (AOR 2.19; 95% CI 1.36-3.52; P < 0.001) were significantly at risk of persistent anaemia.

Conclusions: More than two thirds of patients had anaemia at baseline. The AZT-containing regimen and absence of cotrimoxazole prophylaxis before starting ART were associated with persistent anaemia 12 months, after initiation of treatment. Considering the large proportion of patients with persistence of anaemia at 12 months, we suggest that it is necessary to conduct a large study to assess anaemia among HIV-infected patients in Goma.

No MeSH data available.


Related in: MedlinePlus