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Waterborne Risperidone Decreases Stress Response in Zebrafish.

Idalencio R, Kalichak F, Rosa JG, de Oliveira TA, Koakoski G, Gusso D, Abreu MS, Giacomini AC, Barcellos HH, Piato AL, Barcellos LJ - PLoS ONE (2015)

Bottom Line: The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood.This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish.It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish.

View Article: PubMed Central - PubMed

Affiliation: Programa de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brasil; Laboratório de Fisiologia de Peixes, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brasil.

ABSTRACT
The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish. It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish. The data presented here suggest that the presence of this antipsychotic in aquatic environments can alter neuroendocrine and behavior profiles in zebrafish.

No MeSH data available.


Related in: MedlinePlus

Behavioral parameters of zebrafish in the novel tank test followed by an acute stress protocol.Total distance (A), mean speed (B), crossings between compartments (C), absolute turn angle (D), time spent in the bottom (E), and time in the upper (F). The data are expressed as the mean ± standard error of mean of 5–6 fish. * = p<0.05 compared to Risp 0, S- group; # = p<0.05 compared to Rips 0, S+ group. S- and S+ refer to non-stressed and stressed fish, respectively.
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pone.0140800.g002: Behavioral parameters of zebrafish in the novel tank test followed by an acute stress protocol.Total distance (A), mean speed (B), crossings between compartments (C), absolute turn angle (D), time spent in the bottom (E), and time in the upper (F). The data are expressed as the mean ± standard error of mean of 5–6 fish. * = p<0.05 compared to Risp 0, S- group; # = p<0.05 compared to Rips 0, S+ group. S- and S+ refer to non-stressed and stressed fish, respectively.

Mentions: The Fig 2 shows the effects of risperidone (170 μg/L) in the novel tank test. A significant main effect of treatment was observed for time in the bottom and upper, and a significant interaction between treatment and stress was observed for time in the upper. Table 2 summarizes the results yielded by the statistical analysis for each behavioral parameter evaluated. Post hoc analysis revealed that risperidone increased time spent in the upper in stressed fish. Total distance, mean speed, absolute turn angle, and number of crossings did not differ among experimental groups. The behavioral raw data and the complete statistical analysis are presented in supporting information (S3 File and S4 File).


Waterborne Risperidone Decreases Stress Response in Zebrafish.

Idalencio R, Kalichak F, Rosa JG, de Oliveira TA, Koakoski G, Gusso D, Abreu MS, Giacomini AC, Barcellos HH, Piato AL, Barcellos LJ - PLoS ONE (2015)

Behavioral parameters of zebrafish in the novel tank test followed by an acute stress protocol.Total distance (A), mean speed (B), crossings between compartments (C), absolute turn angle (D), time spent in the bottom (E), and time in the upper (F). The data are expressed as the mean ± standard error of mean of 5–6 fish. * = p<0.05 compared to Risp 0, S- group; # = p<0.05 compared to Rips 0, S+ group. S- and S+ refer to non-stressed and stressed fish, respectively.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608780&req=5

pone.0140800.g002: Behavioral parameters of zebrafish in the novel tank test followed by an acute stress protocol.Total distance (A), mean speed (B), crossings between compartments (C), absolute turn angle (D), time spent in the bottom (E), and time in the upper (F). The data are expressed as the mean ± standard error of mean of 5–6 fish. * = p<0.05 compared to Risp 0, S- group; # = p<0.05 compared to Rips 0, S+ group. S- and S+ refer to non-stressed and stressed fish, respectively.
Mentions: The Fig 2 shows the effects of risperidone (170 μg/L) in the novel tank test. A significant main effect of treatment was observed for time in the bottom and upper, and a significant interaction between treatment and stress was observed for time in the upper. Table 2 summarizes the results yielded by the statistical analysis for each behavioral parameter evaluated. Post hoc analysis revealed that risperidone increased time spent in the upper in stressed fish. Total distance, mean speed, absolute turn angle, and number of crossings did not differ among experimental groups. The behavioral raw data and the complete statistical analysis are presented in supporting information (S3 File and S4 File).

Bottom Line: The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood.This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish.It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish.

View Article: PubMed Central - PubMed

Affiliation: Programa de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brasil; Laboratório de Fisiologia de Peixes, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brasil.

ABSTRACT
The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish. It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish. The data presented here suggest that the presence of this antipsychotic in aquatic environments can alter neuroendocrine and behavior profiles in zebrafish.

No MeSH data available.


Related in: MedlinePlus