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Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype.

Meyer B, Nguyen CB, Moen A, Fagermoen E, Sulheim D, Nilsen H, Wyller VB, Gjerstad J - PLoS ONE (2015)

Bottom Line: Earlier studies have shown that genetic variability in the SLC6A4 gene encoding the serotonin transporter (5-HTT) may be important for the re-uptake of serotonin (5-HT) in the central nervous system.All 120 patients were recruited from The Department of Paediatrics at Oslo University Hospital, Norway, a national referral center for young CFS patients (12-18 years).Main outcomes were number of steps per day obtained by an accelerometer and disability scored by the Functional Disability Inventory (FDI).

View Article: PubMed Central - PubMed

Affiliation: Dept. of Paediatrics, Akershus University Hospital, Oslo, Norway.

ABSTRACT
Earlier studies have shown that genetic variability in the SLC6A4 gene encoding the serotonin transporter (5-HTT) may be important for the re-uptake of serotonin (5-HT) in the central nervous system. In the present study we investigated how the 5-HTT genotype i.e. the short (S) versus long (L) 5-HTTLPR allele and the SNP rs25531 A > G affect the physical and psychosocial functioning in patients with chronic fatigue syndrome (CFS). All 120 patients were recruited from The Department of Paediatrics at Oslo University Hospital, Norway, a national referral center for young CFS patients (12-18 years). Main outcomes were number of steps per day obtained by an accelerometer and disability scored by the Functional Disability Inventory (FDI). Patients with the 5-HTT SS or SLG genotype had a significantly lower number of steps per day than patients with the 5-HTT LALG, SLA or LALA genotype. Patients with the 5-HTT SS or SLG genotype also had a significantly higher FDI score than patients with the 5-HTT LALG, SLA or LALA genotype. Thus, CFS patients with the 5-HTT SS or SLG genotype had worse 30 weeks outcome than CFS patients with the 5-HTT LALG, SLA or LALA genotype. The present study suggests that the 5-HTT genotype may be a factor that contributes to maintenance of CFS.

No MeSH data available.


Related in: MedlinePlus

The time course for outcome measures grouped as 5-HTT SS+SLG genotype, and 5-HTT LALG+SLA+LALA genotype following inclusion.A) Number of steps (repeated measure ANOVA, F(1,116) = 7.23, p = 0.008). B) Functional disability inventory, FDI (repeated measure ANOVA, F(1,115) = 7.81; p = 0.006). Data are given as means ± SEM (Fisher’s LSD post hoc test using Bonferroni correction *p<0.05; **p<0.01.)
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pone.0140883.g003: The time course for outcome measures grouped as 5-HTT SS+SLG genotype, and 5-HTT LALG+SLA+LALA genotype following inclusion.A) Number of steps (repeated measure ANOVA, F(1,116) = 7.23, p = 0.008). B) Functional disability inventory, FDI (repeated measure ANOVA, F(1,115) = 7.81; p = 0.006). Data are given as means ± SEM (Fisher’s LSD post hoc test using Bonferroni correction *p<0.05; **p<0.01.)

Mentions: At inclusion, 8 weeks and 30 weeks, a clear difference between the 5-HTT SS or SLG genotype versus the 5-HTT LALG, SLA or LALA genotype was observed (Fig 3A and 3B). Patients with the SS or SLG genotype had a significantly lower number of steps per day and also a significantly higher FDI score than patients with the LALG, SLA or LALA genotype when gender was taken into account as a covariate (repeated measures ANOVA, between-subjects effect, steps per day F(1,116) = 7.23, p = 0.008; FDI score F(1,115) = 7.81; p = 0.006).


Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype.

Meyer B, Nguyen CB, Moen A, Fagermoen E, Sulheim D, Nilsen H, Wyller VB, Gjerstad J - PLoS ONE (2015)

The time course for outcome measures grouped as 5-HTT SS+SLG genotype, and 5-HTT LALG+SLA+LALA genotype following inclusion.A) Number of steps (repeated measure ANOVA, F(1,116) = 7.23, p = 0.008). B) Functional disability inventory, FDI (repeated measure ANOVA, F(1,115) = 7.81; p = 0.006). Data are given as means ± SEM (Fisher’s LSD post hoc test using Bonferroni correction *p<0.05; **p<0.01.)
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608737&req=5

pone.0140883.g003: The time course for outcome measures grouped as 5-HTT SS+SLG genotype, and 5-HTT LALG+SLA+LALA genotype following inclusion.A) Number of steps (repeated measure ANOVA, F(1,116) = 7.23, p = 0.008). B) Functional disability inventory, FDI (repeated measure ANOVA, F(1,115) = 7.81; p = 0.006). Data are given as means ± SEM (Fisher’s LSD post hoc test using Bonferroni correction *p<0.05; **p<0.01.)
Mentions: At inclusion, 8 weeks and 30 weeks, a clear difference between the 5-HTT SS or SLG genotype versus the 5-HTT LALG, SLA or LALA genotype was observed (Fig 3A and 3B). Patients with the SS or SLG genotype had a significantly lower number of steps per day and also a significantly higher FDI score than patients with the LALG, SLA or LALA genotype when gender was taken into account as a covariate (repeated measures ANOVA, between-subjects effect, steps per day F(1,116) = 7.23, p = 0.008; FDI score F(1,115) = 7.81; p = 0.006).

Bottom Line: Earlier studies have shown that genetic variability in the SLC6A4 gene encoding the serotonin transporter (5-HTT) may be important for the re-uptake of serotonin (5-HT) in the central nervous system.All 120 patients were recruited from The Department of Paediatrics at Oslo University Hospital, Norway, a national referral center for young CFS patients (12-18 years).Main outcomes were number of steps per day obtained by an accelerometer and disability scored by the Functional Disability Inventory (FDI).

View Article: PubMed Central - PubMed

Affiliation: Dept. of Paediatrics, Akershus University Hospital, Oslo, Norway.

ABSTRACT
Earlier studies have shown that genetic variability in the SLC6A4 gene encoding the serotonin transporter (5-HTT) may be important for the re-uptake of serotonin (5-HT) in the central nervous system. In the present study we investigated how the 5-HTT genotype i.e. the short (S) versus long (L) 5-HTTLPR allele and the SNP rs25531 A > G affect the physical and psychosocial functioning in patients with chronic fatigue syndrome (CFS). All 120 patients were recruited from The Department of Paediatrics at Oslo University Hospital, Norway, a national referral center for young CFS patients (12-18 years). Main outcomes were number of steps per day obtained by an accelerometer and disability scored by the Functional Disability Inventory (FDI). Patients with the 5-HTT SS or SLG genotype had a significantly lower number of steps per day than patients with the 5-HTT LALG, SLA or LALA genotype. Patients with the 5-HTT SS or SLG genotype also had a significantly higher FDI score than patients with the 5-HTT LALG, SLA or LALA genotype. Thus, CFS patients with the 5-HTT SS or SLG genotype had worse 30 weeks outcome than CFS patients with the 5-HTT LALG, SLA or LALA genotype. The present study suggests that the 5-HTT genotype may be a factor that contributes to maintenance of CFS.

No MeSH data available.


Related in: MedlinePlus