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Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype.

Meyer B, Nguyen CB, Moen A, Fagermoen E, Sulheim D, Nilsen H, Wyller VB, Gjerstad J - PLoS ONE (2015)

Bottom Line: Earlier studies have shown that genetic variability in the SLC6A4 gene encoding the serotonin transporter (5-HTT) may be important for the re-uptake of serotonin (5-HT) in the central nervous system.All 120 patients were recruited from The Department of Paediatrics at Oslo University Hospital, Norway, a national referral center for young CFS patients (12-18 years).Main outcomes were number of steps per day obtained by an accelerometer and disability scored by the Functional Disability Inventory (FDI).

View Article: PubMed Central - PubMed

Affiliation: Dept. of Paediatrics, Akershus University Hospital, Oslo, Norway.

ABSTRACT
Earlier studies have shown that genetic variability in the SLC6A4 gene encoding the serotonin transporter (5-HTT) may be important for the re-uptake of serotonin (5-HT) in the central nervous system. In the present study we investigated how the 5-HTT genotype i.e. the short (S) versus long (L) 5-HTTLPR allele and the SNP rs25531 A > G affect the physical and psychosocial functioning in patients with chronic fatigue syndrome (CFS). All 120 patients were recruited from The Department of Paediatrics at Oslo University Hospital, Norway, a national referral center for young CFS patients (12-18 years). Main outcomes were number of steps per day obtained by an accelerometer and disability scored by the Functional Disability Inventory (FDI). Patients with the 5-HTT SS or SLG genotype had a significantly lower number of steps per day than patients with the 5-HTT LALG, SLA or LALA genotype. Patients with the 5-HTT SS or SLG genotype also had a significantly higher FDI score than patients with the 5-HTT LALG, SLA or LALA genotype. Thus, CFS patients with the 5-HTT SS or SLG genotype had worse 30 weeks outcome than CFS patients with the 5-HTT LALG, SLA or LALA genotype. The present study suggests that the 5-HTT genotype may be a factor that contributes to maintenance of CFS.

No MeSH data available.


Related in: MedlinePlus

Daily activity and disability scores in 5-HTT genotype stratified data; SS, SLG, LALG, SLA and LALA.A and B) Mean number of steps per day and Functional Disability Inventory (FDI) score in the patients at the time of inclusion. C and D) Mean number of steps per day and Functional Disability Inventory (FDI) score in the reference group i.e. healthy control subjects. Data are given as means ± SEM (Student’s t-test, SS+SLG versus LALG+SLA+LALA *p<0.05).
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pone.0140883.g002: Daily activity and disability scores in 5-HTT genotype stratified data; SS, SLG, LALG, SLA and LALA.A and B) Mean number of steps per day and Functional Disability Inventory (FDI) score in the patients at the time of inclusion. C and D) Mean number of steps per day and Functional Disability Inventory (FDI) score in the reference group i.e. healthy control subjects. Data are given as means ± SEM (Student’s t-test, SS+SLG versus LALG+SLA+LALA *p<0.05).

Mentions: At inclusion the 31 patients with the SS or SLG genotype had a lower number of steps per day and a higher FDI score than the 89 patients with the LALG, SLA or LALA genotype (Fig 2A and 2B). No genotype effects were observed in the healthy controls (Fig 2C and 2D). Moreover, the frequency of the SS or SLG genotype was not significantly higher in the patients than in the healthy controls; p = 0.55 (Table 1).


Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype.

Meyer B, Nguyen CB, Moen A, Fagermoen E, Sulheim D, Nilsen H, Wyller VB, Gjerstad J - PLoS ONE (2015)

Daily activity and disability scores in 5-HTT genotype stratified data; SS, SLG, LALG, SLA and LALA.A and B) Mean number of steps per day and Functional Disability Inventory (FDI) score in the patients at the time of inclusion. C and D) Mean number of steps per day and Functional Disability Inventory (FDI) score in the reference group i.e. healthy control subjects. Data are given as means ± SEM (Student’s t-test, SS+SLG versus LALG+SLA+LALA *p<0.05).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608737&req=5

pone.0140883.g002: Daily activity and disability scores in 5-HTT genotype stratified data; SS, SLG, LALG, SLA and LALA.A and B) Mean number of steps per day and Functional Disability Inventory (FDI) score in the patients at the time of inclusion. C and D) Mean number of steps per day and Functional Disability Inventory (FDI) score in the reference group i.e. healthy control subjects. Data are given as means ± SEM (Student’s t-test, SS+SLG versus LALG+SLA+LALA *p<0.05).
Mentions: At inclusion the 31 patients with the SS or SLG genotype had a lower number of steps per day and a higher FDI score than the 89 patients with the LALG, SLA or LALA genotype (Fig 2A and 2B). No genotype effects were observed in the healthy controls (Fig 2C and 2D). Moreover, the frequency of the SS or SLG genotype was not significantly higher in the patients than in the healthy controls; p = 0.55 (Table 1).

Bottom Line: Earlier studies have shown that genetic variability in the SLC6A4 gene encoding the serotonin transporter (5-HTT) may be important for the re-uptake of serotonin (5-HT) in the central nervous system.All 120 patients were recruited from The Department of Paediatrics at Oslo University Hospital, Norway, a national referral center for young CFS patients (12-18 years).Main outcomes were number of steps per day obtained by an accelerometer and disability scored by the Functional Disability Inventory (FDI).

View Article: PubMed Central - PubMed

Affiliation: Dept. of Paediatrics, Akershus University Hospital, Oslo, Norway.

ABSTRACT
Earlier studies have shown that genetic variability in the SLC6A4 gene encoding the serotonin transporter (5-HTT) may be important for the re-uptake of serotonin (5-HT) in the central nervous system. In the present study we investigated how the 5-HTT genotype i.e. the short (S) versus long (L) 5-HTTLPR allele and the SNP rs25531 A > G affect the physical and psychosocial functioning in patients with chronic fatigue syndrome (CFS). All 120 patients were recruited from The Department of Paediatrics at Oslo University Hospital, Norway, a national referral center for young CFS patients (12-18 years). Main outcomes were number of steps per day obtained by an accelerometer and disability scored by the Functional Disability Inventory (FDI). Patients with the 5-HTT SS or SLG genotype had a significantly lower number of steps per day than patients with the 5-HTT LALG, SLA or LALA genotype. Patients with the 5-HTT SS or SLG genotype also had a significantly higher FDI score than patients with the 5-HTT LALG, SLA or LALA genotype. Thus, CFS patients with the 5-HTT SS or SLG genotype had worse 30 weeks outcome than CFS patients with the 5-HTT LALG, SLA or LALA genotype. The present study suggests that the 5-HTT genotype may be a factor that contributes to maintenance of CFS.

No MeSH data available.


Related in: MedlinePlus