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Curcumin Mimics the Neurocognitive and Anti-Inflammatory Effects of Caloric Restriction in a Mouse Model of Midlife Obesity.

Sarker MR, Franks S, Sumien N, Thangthaeng N, Filipetto F, Forster M - PLoS ONE (2015)

Bottom Line: Dietary curcumin was studied for its potential to decrease adiposity and reverse obesity- associated cognitive impairment in a mouse model of midlife sedentary obesity.Blood markers of inflammation, interleukin 6 (IL-6) and C-reactive protein (CRP), as well as an indicator of redox stress (GSH: GSSG ratio), were determined at different time points during the treatments, and visceral and subcutaneous adipose tissue were measured upon completion of the experiment.The results suggest that, independent of their effects on adiposity; dietary curcumin and caloric restriction have positive effects on frontal cortical functions that could be linked to anti-inflammatory or antioxidant actions.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer's Disease Research (IAADR), University of North Texas Health Science Center, Fort Worth, Texas, United States of America.

ABSTRACT
Dietary curcumin was studied for its potential to decrease adiposity and reverse obesity- associated cognitive impairment in a mouse model of midlife sedentary obesity. We hypothesized that curcumin intake, by decreasing adiposity, would improve cognitive function in a manner comparable to caloric restriction (CR), a weight loss regimen. 15-month-old male C57BL/6 mice were assigned in groups to receive the following dietary regimens for 12 weeks: (i) a base diet (Ain93M) fed ad libitum (AL), (ii) the base diet restricted to 70% of ad libitum (CR) or (iii) the base diet containing curcumin fed AL (1000 mg/kg diet, CURAL). Blood markers of inflammation, interleukin 6 (IL-6) and C-reactive protein (CRP), as well as an indicator of redox stress (GSH: GSSG ratio), were determined at different time points during the treatments, and visceral and subcutaneous adipose tissue were measured upon completion of the experiment. After 8 weeks of dietary treatment, the mice were tested for spatial cognition (Morris water maze) and cognitive flexibility (discriminated active avoidance). The CR group showed significant weight loss and reduced adiposity, whereas CURAL mice had stable weight throughout the experiment, consumed more food than the AL group, with no reduction of adiposity. However, both CR and CURAL groups took fewer trials than AL to reach criterion during the reversal sessions of the active avoidance task, suggesting an improvement in cognitive flexibility. The AL mice had higher levels of CRP compared to CURAL and CR, and GSH as well as the GSH: GSSG ratio were increased during curcumin intake, suggesting a reducing shift in the redox state. The results suggest that, independent of their effects on adiposity; dietary curcumin and caloric restriction have positive effects on frontal cortical functions that could be linked to anti-inflammatory or antioxidant actions.

No MeSH data available.


Related in: MedlinePlus

Water maze performance.The effect of dietary treatment on the efficiency to locate a hidden platform (path length) as a function of training sessions. All data represent means ± SE, n = 18–19.
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pone.0140431.g006: Water maze performance.The effect of dietary treatment on the efficiency to locate a hidden platform (path length) as a function of training sessions. All data represent means ± SE, n = 18–19.

Mentions: The distance to reach the hidden platform (path length) was determined during sessions 1–9 to assess the efficiency with which the mice located the platform regardless of their swimming speed. Over sessions 1–4, all groups showed improvement in their efficiency to reach the platform (Fig 6), and there was no apparent difference among the treatment groups in the spatial learning index (S2 Table) or during probe trials conducted after sessions 2 and 4 (data not shown). Performance during the second week remained relatively stable for the treatment groups. Data analysis failed to indicate a significant effect of diet or interaction of diet with test phase or session (all P>0.62). Probe trial data calculated from percent time spent in the 40-cm annulus around the target site (not shown) confirmed that mice in the different treatment groups had acquired a spatial bias for the platform location that was maintained through session 9. However, analysis of the probe data failed to indicate a significant main effect or interaction involving diet (all P>0.15).


Curcumin Mimics the Neurocognitive and Anti-Inflammatory Effects of Caloric Restriction in a Mouse Model of Midlife Obesity.

Sarker MR, Franks S, Sumien N, Thangthaeng N, Filipetto F, Forster M - PLoS ONE (2015)

Water maze performance.The effect of dietary treatment on the efficiency to locate a hidden platform (path length) as a function of training sessions. All data represent means ± SE, n = 18–19.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608712&req=5

pone.0140431.g006: Water maze performance.The effect of dietary treatment on the efficiency to locate a hidden platform (path length) as a function of training sessions. All data represent means ± SE, n = 18–19.
Mentions: The distance to reach the hidden platform (path length) was determined during sessions 1–9 to assess the efficiency with which the mice located the platform regardless of their swimming speed. Over sessions 1–4, all groups showed improvement in their efficiency to reach the platform (Fig 6), and there was no apparent difference among the treatment groups in the spatial learning index (S2 Table) or during probe trials conducted after sessions 2 and 4 (data not shown). Performance during the second week remained relatively stable for the treatment groups. Data analysis failed to indicate a significant effect of diet or interaction of diet with test phase or session (all P>0.62). Probe trial data calculated from percent time spent in the 40-cm annulus around the target site (not shown) confirmed that mice in the different treatment groups had acquired a spatial bias for the platform location that was maintained through session 9. However, analysis of the probe data failed to indicate a significant main effect or interaction involving diet (all P>0.15).

Bottom Line: Dietary curcumin was studied for its potential to decrease adiposity and reverse obesity- associated cognitive impairment in a mouse model of midlife sedentary obesity.Blood markers of inflammation, interleukin 6 (IL-6) and C-reactive protein (CRP), as well as an indicator of redox stress (GSH: GSSG ratio), were determined at different time points during the treatments, and visceral and subcutaneous adipose tissue were measured upon completion of the experiment.The results suggest that, independent of their effects on adiposity; dietary curcumin and caloric restriction have positive effects on frontal cortical functions that could be linked to anti-inflammatory or antioxidant actions.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer's Disease Research (IAADR), University of North Texas Health Science Center, Fort Worth, Texas, United States of America.

ABSTRACT
Dietary curcumin was studied for its potential to decrease adiposity and reverse obesity- associated cognitive impairment in a mouse model of midlife sedentary obesity. We hypothesized that curcumin intake, by decreasing adiposity, would improve cognitive function in a manner comparable to caloric restriction (CR), a weight loss regimen. 15-month-old male C57BL/6 mice were assigned in groups to receive the following dietary regimens for 12 weeks: (i) a base diet (Ain93M) fed ad libitum (AL), (ii) the base diet restricted to 70% of ad libitum (CR) or (iii) the base diet containing curcumin fed AL (1000 mg/kg diet, CURAL). Blood markers of inflammation, interleukin 6 (IL-6) and C-reactive protein (CRP), as well as an indicator of redox stress (GSH: GSSG ratio), were determined at different time points during the treatments, and visceral and subcutaneous adipose tissue were measured upon completion of the experiment. After 8 weeks of dietary treatment, the mice were tested for spatial cognition (Morris water maze) and cognitive flexibility (discriminated active avoidance). The CR group showed significant weight loss and reduced adiposity, whereas CURAL mice had stable weight throughout the experiment, consumed more food than the AL group, with no reduction of adiposity. However, both CR and CURAL groups took fewer trials than AL to reach criterion during the reversal sessions of the active avoidance task, suggesting an improvement in cognitive flexibility. The AL mice had higher levels of CRP compared to CURAL and CR, and GSH as well as the GSH: GSSG ratio were increased during curcumin intake, suggesting a reducing shift in the redox state. The results suggest that, independent of their effects on adiposity; dietary curcumin and caloric restriction have positive effects on frontal cortical functions that could be linked to anti-inflammatory or antioxidant actions.

No MeSH data available.


Related in: MedlinePlus