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Statin Use Is Associated with Reduced Mortality in Patients with Interstitial Lung Disease.

Vedel-Krogh S, Nielsen SF, Nordestgaard BG - PLoS ONE (2015)

Bottom Line: Corresponding values in patients with idiopathic lung fibrosis were 3.4 versus 2.4 years.Results were robust in all sensitivity analyses.Among patients with interstitial lung disease statin use was associated with reduced all-cause mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Biochemistry, Herlev and Gentofte Hospitals, Copenhagen University Hospital, Herlev, Denmark.

ABSTRACT

Introduction: We hypothesized that statin use begun before the diagnosis of interstitial lung disease is associated with reduced mortality.

Methods: We studied all patients diagnosed with interstitial lung disease in the entire Danish population from 1995 through 2009, comparing statin use versus no statin use in a nested 1:2 matched study.

Results: The cumulative survival as a function of follow-up time from the date of diagnosis of interstitial lung disease (n = 1,786 + 3,572) and idiopathic lung fibrosis (n = 261 + 522) was higher for statin users versus never users (log-rank: P = 7 · 10(-9) and P = 0.05). The median survival time in patients with interstitial lung disease was 3.3 years in statin users and 2.1 years in never users. Corresponding values in patients with idiopathic lung fibrosis were 3.4 versus 2.4 years. After multivariable adjustment, the hazard ratio for all-cause mortality for statin users versus never users was 0.73 (95% confidence interval, 0.68 to 0.79) in patients with interstitial lung disease and 0.76 (0.62 to 0.93) in patients with idiopathic lung fibrosis. Results were robust in all sensitivity analyses.

Conclusion: Among patients with interstitial lung disease statin use was associated with reduced all-cause mortality.

No MeSH data available.


Related in: MedlinePlus

Risk of all-cause mortality in statin users versus never users stratified for covariates.Hazard ratios are shown after multivariable adjustments. Year of diagnosis was divided into two periods, 1995–2003 and 2004–2009, as a consensus on classification of idiopathic lung fibrosis was published in 2002 [19].
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pone.0140571.g005: Risk of all-cause mortality in statin users versus never users stratified for covariates.Hazard ratios are shown after multivariable adjustments. Year of diagnosis was divided into two periods, 1995–2003 and 2004–2009, as a consensus on classification of idiopathic lung fibrosis was published in 2002 [19].

Mentions: In analyses stratified for characteristics which could be associated with statin use, interstitial lung disease diagnosis, and/or risk of all-cause mortality, that is, for sex, chronic obstructive pulmonary disease before interstitial lung disease, cardiovascular disease before interstitial lung disease, diabetes mellitus before interstitial lung disease, residential city size, education, year of diagnosis and age at diagnosis, all-cause mortality was reduced in statin users versus never users in all strata (Fig 5).


Statin Use Is Associated with Reduced Mortality in Patients with Interstitial Lung Disease.

Vedel-Krogh S, Nielsen SF, Nordestgaard BG - PLoS ONE (2015)

Risk of all-cause mortality in statin users versus never users stratified for covariates.Hazard ratios are shown after multivariable adjustments. Year of diagnosis was divided into two periods, 1995–2003 and 2004–2009, as a consensus on classification of idiopathic lung fibrosis was published in 2002 [19].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608706&req=5

pone.0140571.g005: Risk of all-cause mortality in statin users versus never users stratified for covariates.Hazard ratios are shown after multivariable adjustments. Year of diagnosis was divided into two periods, 1995–2003 and 2004–2009, as a consensus on classification of idiopathic lung fibrosis was published in 2002 [19].
Mentions: In analyses stratified for characteristics which could be associated with statin use, interstitial lung disease diagnosis, and/or risk of all-cause mortality, that is, for sex, chronic obstructive pulmonary disease before interstitial lung disease, cardiovascular disease before interstitial lung disease, diabetes mellitus before interstitial lung disease, residential city size, education, year of diagnosis and age at diagnosis, all-cause mortality was reduced in statin users versus never users in all strata (Fig 5).

Bottom Line: Corresponding values in patients with idiopathic lung fibrosis were 3.4 versus 2.4 years.Results were robust in all sensitivity analyses.Among patients with interstitial lung disease statin use was associated with reduced all-cause mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Biochemistry, Herlev and Gentofte Hospitals, Copenhagen University Hospital, Herlev, Denmark.

ABSTRACT

Introduction: We hypothesized that statin use begun before the diagnosis of interstitial lung disease is associated with reduced mortality.

Methods: We studied all patients diagnosed with interstitial lung disease in the entire Danish population from 1995 through 2009, comparing statin use versus no statin use in a nested 1:2 matched study.

Results: The cumulative survival as a function of follow-up time from the date of diagnosis of interstitial lung disease (n = 1,786 + 3,572) and idiopathic lung fibrosis (n = 261 + 522) was higher for statin users versus never users (log-rank: P = 7 · 10(-9) and P = 0.05). The median survival time in patients with interstitial lung disease was 3.3 years in statin users and 2.1 years in never users. Corresponding values in patients with idiopathic lung fibrosis were 3.4 versus 2.4 years. After multivariable adjustment, the hazard ratio for all-cause mortality for statin users versus never users was 0.73 (95% confidence interval, 0.68 to 0.79) in patients with interstitial lung disease and 0.76 (0.62 to 0.93) in patients with idiopathic lung fibrosis. Results were robust in all sensitivity analyses.

Conclusion: Among patients with interstitial lung disease statin use was associated with reduced all-cause mortality.

No MeSH data available.


Related in: MedlinePlus