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Health-Related Quality of Life in Relation to Obesity Grade, Type 2 Diabetes, Metabolic Syndrome and Inflammation.

Slagter SN, van Vliet-Ostaptchouk JV, van Beek AP, Keers JC, Lutgers HL, van der Klauw MM, Wolffenbuttel BH - PLoS ONE (2015)

Bottom Line: The aim of this study is to assess the effect of obesity-related conditions on HR-QoL.Obese women with increased inflammation levels were more likely to have poor scores on all domains except role limitations due to emotional problems and mental health.The mental well-being is less often impaired.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

ABSTRACT

Background: Health-related quality of life (HR-QoL) may be compromised in obese individuals, depending on the presence of other complications. The aim of this study is to assess the effect of obesity-related conditions on HR-QoL. These conditions are i) grade of obesity with and without type 2 diabetes (T2D), ii) metabolic syndrome (MetS), and iii) level of inflammation.

Methods: From the Dutch LifeLines Cohort Study we included 13,686 obese individuals, aged 18-80 years. HR-QoL was measured with the RAND 36-Item Health Survey which encompasses eight health domains. We calculated the percentage of obese individuals with poor HR-QoL, i.e. those scoring below the domain and sex specific cut-off value derived from the normal weight population. Logistic regression analysis was used to calculate the probability of having poor domain scores according to the conditions under study.

Results: Higher grades of obesity and the additional presence of T2D were associated with lower HR-QoL, particularly in the domains physical functioning (men: odds ratios (ORs) 1.48-11.34, P<0.005, and women: ORs 1.66-5.05, P<0.001) and general health (men: ORs 1.44-3.07, P<0.005, and women: ORs 1.36-3.73, P<0.001). A higher percentage of obese individuals with MetS had a poor HR-QoL than those without MetS. Furthermore, we observed a linear trend between inflammation and the percentage of obese individuals with poor scores on the HR-QoL domains. Individuals with MetS were more likely to have poor scores in the domains general health, vitality, social functioning and role limitations due to emotional problems. Obese women with increased inflammation levels were more likely to have poor scores on all domains except role limitations due to emotional problems and mental health.

Conclusions: The impact of obesity on an individual's quality of life is enhanced by grade of obesity, T2D, MetS and inflammation and are mainly related to reduced physical health. The mental well-being is less often impaired.

No MeSH data available.


Related in: MedlinePlus

Percentages of obese individuals with a poor HR-QoL domain score, according to level of hs-CRP.(A) Men. (B) Women. hs-CRP = high sensitivity C-reactive protein. The corresponding cut-off value derived from the scores in the normal weight population for the individual domains (25th percentile men, 25th percentile women): PF = physical functioning (95.0, 90.0); RP = role limitations due to physical health problems (100.0, 100.0); BP = bodily pain (79.6, 67.4); GH = general health (65.0, 65.0); VT = vitality (60.0, 55.0); SF = social functioning (87.5, 75.0); RE = role limitations due to emotional problems (100.0, 100.0); MH = mental health (76.0, 72.0). Mantel-Haenszel tests was used to check for a linear trend in proportions across groups of hs-CRP level within the obese population. * indicates a linear trend for individuals with obesity and higher levels of hs-CRP at P <0.005; aP <0.001; and bP <0.002.
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pone.0140599.g003: Percentages of obese individuals with a poor HR-QoL domain score, according to level of hs-CRP.(A) Men. (B) Women. hs-CRP = high sensitivity C-reactive protein. The corresponding cut-off value derived from the scores in the normal weight population for the individual domains (25th percentile men, 25th percentile women): PF = physical functioning (95.0, 90.0); RP = role limitations due to physical health problems (100.0, 100.0); BP = bodily pain (79.6, 67.4); GH = general health (65.0, 65.0); VT = vitality (60.0, 55.0); SF = social functioning (87.5, 75.0); RE = role limitations due to emotional problems (100.0, 100.0); MH = mental health (76.0, 72.0). Mantel-Haenszel tests was used to check for a linear trend in proportions across groups of hs-CRP level within the obese population. * indicates a linear trend for individuals with obesity and higher levels of hs-CRP at P <0.005; aP <0.001; and bP <0.002.

Mentions: Fig 1, Fig 2 and Fig 3 represent the sex-specific percentages of obese individuals with a poor score on the HR-QoL domains. With a higher grade of obesity and/or who had T2D, higher percentages of individuals had a poor HR-QoL, especially in the domains physical functioning (PF) and general health (GH) (Fig 1). Compared to those with grade 1 obesity and no T2D, 45.0% more men and 39.0% more women with grade 3 obesity and T2D had a poor score on physical functioning. For general health these differences were 29.1% and 34.9%, respectively. For all domains, the percentage of men and women with obesity and a poor score was higher in those with MetS (Fig 2). Again, poor scores on HR-QoL was most often reported in the domains physical functioning and general health. Individuals with higher levels of inflammation scored worse on HR-QoL (Fig 3). This trend was most prominent in the group with hs-CRP >3 mg/L, and in the domains mainly related to physical health and the domain vitality (VT). The percentage of individuals who had a poor score on the domain bodily pain varied between 32.2–41.9% in men and 18.5–27.8% in women (Fig 3).


Health-Related Quality of Life in Relation to Obesity Grade, Type 2 Diabetes, Metabolic Syndrome and Inflammation.

Slagter SN, van Vliet-Ostaptchouk JV, van Beek AP, Keers JC, Lutgers HL, van der Klauw MM, Wolffenbuttel BH - PLoS ONE (2015)

Percentages of obese individuals with a poor HR-QoL domain score, according to level of hs-CRP.(A) Men. (B) Women. hs-CRP = high sensitivity C-reactive protein. The corresponding cut-off value derived from the scores in the normal weight population for the individual domains (25th percentile men, 25th percentile women): PF = physical functioning (95.0, 90.0); RP = role limitations due to physical health problems (100.0, 100.0); BP = bodily pain (79.6, 67.4); GH = general health (65.0, 65.0); VT = vitality (60.0, 55.0); SF = social functioning (87.5, 75.0); RE = role limitations due to emotional problems (100.0, 100.0); MH = mental health (76.0, 72.0). Mantel-Haenszel tests was used to check for a linear trend in proportions across groups of hs-CRP level within the obese population. * indicates a linear trend for individuals with obesity and higher levels of hs-CRP at P <0.005; aP <0.001; and bP <0.002.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4608696&req=5

pone.0140599.g003: Percentages of obese individuals with a poor HR-QoL domain score, according to level of hs-CRP.(A) Men. (B) Women. hs-CRP = high sensitivity C-reactive protein. The corresponding cut-off value derived from the scores in the normal weight population for the individual domains (25th percentile men, 25th percentile women): PF = physical functioning (95.0, 90.0); RP = role limitations due to physical health problems (100.0, 100.0); BP = bodily pain (79.6, 67.4); GH = general health (65.0, 65.0); VT = vitality (60.0, 55.0); SF = social functioning (87.5, 75.0); RE = role limitations due to emotional problems (100.0, 100.0); MH = mental health (76.0, 72.0). Mantel-Haenszel tests was used to check for a linear trend in proportions across groups of hs-CRP level within the obese population. * indicates a linear trend for individuals with obesity and higher levels of hs-CRP at P <0.005; aP <0.001; and bP <0.002.
Mentions: Fig 1, Fig 2 and Fig 3 represent the sex-specific percentages of obese individuals with a poor score on the HR-QoL domains. With a higher grade of obesity and/or who had T2D, higher percentages of individuals had a poor HR-QoL, especially in the domains physical functioning (PF) and general health (GH) (Fig 1). Compared to those with grade 1 obesity and no T2D, 45.0% more men and 39.0% more women with grade 3 obesity and T2D had a poor score on physical functioning. For general health these differences were 29.1% and 34.9%, respectively. For all domains, the percentage of men and women with obesity and a poor score was higher in those with MetS (Fig 2). Again, poor scores on HR-QoL was most often reported in the domains physical functioning and general health. Individuals with higher levels of inflammation scored worse on HR-QoL (Fig 3). This trend was most prominent in the group with hs-CRP >3 mg/L, and in the domains mainly related to physical health and the domain vitality (VT). The percentage of individuals who had a poor score on the domain bodily pain varied between 32.2–41.9% in men and 18.5–27.8% in women (Fig 3).

Bottom Line: The aim of this study is to assess the effect of obesity-related conditions on HR-QoL.Obese women with increased inflammation levels were more likely to have poor scores on all domains except role limitations due to emotional problems and mental health.The mental well-being is less often impaired.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

ABSTRACT

Background: Health-related quality of life (HR-QoL) may be compromised in obese individuals, depending on the presence of other complications. The aim of this study is to assess the effect of obesity-related conditions on HR-QoL. These conditions are i) grade of obesity with and without type 2 diabetes (T2D), ii) metabolic syndrome (MetS), and iii) level of inflammation.

Methods: From the Dutch LifeLines Cohort Study we included 13,686 obese individuals, aged 18-80 years. HR-QoL was measured with the RAND 36-Item Health Survey which encompasses eight health domains. We calculated the percentage of obese individuals with poor HR-QoL, i.e. those scoring below the domain and sex specific cut-off value derived from the normal weight population. Logistic regression analysis was used to calculate the probability of having poor domain scores according to the conditions under study.

Results: Higher grades of obesity and the additional presence of T2D were associated with lower HR-QoL, particularly in the domains physical functioning (men: odds ratios (ORs) 1.48-11.34, P<0.005, and women: ORs 1.66-5.05, P<0.001) and general health (men: ORs 1.44-3.07, P<0.005, and women: ORs 1.36-3.73, P<0.001). A higher percentage of obese individuals with MetS had a poor HR-QoL than those without MetS. Furthermore, we observed a linear trend between inflammation and the percentage of obese individuals with poor scores on the HR-QoL domains. Individuals with MetS were more likely to have poor scores in the domains general health, vitality, social functioning and role limitations due to emotional problems. Obese women with increased inflammation levels were more likely to have poor scores on all domains except role limitations due to emotional problems and mental health.

Conclusions: The impact of obesity on an individual's quality of life is enhanced by grade of obesity, T2D, MetS and inflammation and are mainly related to reduced physical health. The mental well-being is less often impaired.

No MeSH data available.


Related in: MedlinePlus