Limits...
Benefits of Regular Exercise on Inflammatory and Cardiovascular Risk Markers in Normal Weight, Overweight and Obese Adults.

Gondim OS, de Camargo VT, Gutierrez FA, Martins PF, Passos ME, Momesso CM, Santos VC, Gorjão R, Pithon-Curi TC, Cury-Boaventura MF - PLoS ONE (2015)

Bottom Line: There is a complicated relationship between adipokines and low-grade inflammation in obesity and cardiovascular disease (CVD).Physical activity practices have beneficial health effects on obesity and related disorders such as hypertension and dyslipidemia.Leptin, IL-6 levels and systolic blood pressure were significantly elevated in OBG before the training.

View Article: PubMed Central - PubMed

Affiliation: Institute of Physical Activity and Sports Sciences, Post-Graduate Program in Human Movement Science, Cruzeiro do Sul University, São Paulo, SP, Brazil.

ABSTRACT
Obesity is a worldwide epidemic that increases the risk of several well-known co-morbidities. There is a complicated relationship between adipokines and low-grade inflammation in obesity and cardiovascular disease (CVD). Physical activity practices have beneficial health effects on obesity and related disorders such as hypertension and dyslipidemia. We investigated the effects of 6 and 12 months of moderate physical training on the levels of adipokines and CVD markers in normal weight, overweight and obese volunteers. The 143 participants were followed up at baseline and after six and twelfth months of moderate regular exercise, 2 times a week, for 12 months. The volunteers were distributed into 3 groups: Normal Weight Group (NWG,), Overweight Group (OVG) and Obese Group (OBG). We evaluated blood pressure, resting heart rate, anthropometric parameters, body composition, fitness capacity (VO2max and isometric back strength), cardiovascular markers (CRP, total cholesterol, LDL-c, HDL-c, homocysteine) and adipokine levels (leptin, adiponectin, resistin, IL-6 and TNF-alpha). There were no significant changes in anthropometric parameters and body composition in any of the groups following 6 and 12 months of exercise training. Leptin, IL-6 levels and systolic blood pressure were significantly elevated in OBG before the training. Regular exercise decreased HDL-c, leptin, adiponectin and resistin levels and diastolic blood pressure in OVG. In OBG, exercise diminished HDL-c, homocysteine, leptin, resistin, IL-6, adiponectin. Moderate exercise had no effect on the body composition; however, exercise did promote beneficial effects on the low-grade inflammatory state and CVD clinical markers in overweight and obese individuals.

No MeSH data available.


Related in: MedlinePlus

Effect of exercise on adipokines in normal weight (NWG), overweight (OVG) and obese (OBG) groups.Plasma and serum was separated immediately after blood collection before (T0), after 6 months (T6) and 12 months (T12) of the exercise training program. The plasma or serum concentrations of leptin, adiponectin, IL-6 and resistin were determined using an Enzyme-linked immunosorbent assay (ELISA) method. The values presented are the mean ± standard error of mean. a comparison to normal weight group; b comparison to overweight group; c comparison to before program training (T0); d comparison to after 6 months of program training.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4608693&req=5

pone.0140596.g002: Effect of exercise on adipokines in normal weight (NWG), overweight (OVG) and obese (OBG) groups.Plasma and serum was separated immediately after blood collection before (T0), after 6 months (T6) and 12 months (T12) of the exercise training program. The plasma or serum concentrations of leptin, adiponectin, IL-6 and resistin were determined using an Enzyme-linked immunosorbent assay (ELISA) method. The values presented are the mean ± standard error of mean. a comparison to normal weight group; b comparison to overweight group; c comparison to before program training (T0); d comparison to after 6 months of program training.

Mentions: Leptin and IL-6 levels were significantly elevated in OBG before the training (Fig 2). The chronic exercise had no effect on adipokine levels in NWG; however, training decreased leptin and adiponectin levels (by approximately 34% and 15%, respectively) after 12 months and resistin by 15% after 6 and 12 months in OVG. In OBG, the exercise diminished the leptin and resistin concentration by 12–18% after 6 months, IL-6 after 6 and 12 months (by 41–53%) and adiponectin by 18% after 12 months (Fig 2).


Benefits of Regular Exercise on Inflammatory and Cardiovascular Risk Markers in Normal Weight, Overweight and Obese Adults.

Gondim OS, de Camargo VT, Gutierrez FA, Martins PF, Passos ME, Momesso CM, Santos VC, Gorjão R, Pithon-Curi TC, Cury-Boaventura MF - PLoS ONE (2015)

Effect of exercise on adipokines in normal weight (NWG), overweight (OVG) and obese (OBG) groups.Plasma and serum was separated immediately after blood collection before (T0), after 6 months (T6) and 12 months (T12) of the exercise training program. The plasma or serum concentrations of leptin, adiponectin, IL-6 and resistin were determined using an Enzyme-linked immunosorbent assay (ELISA) method. The values presented are the mean ± standard error of mean. a comparison to normal weight group; b comparison to overweight group; c comparison to before program training (T0); d comparison to after 6 months of program training.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608693&req=5

pone.0140596.g002: Effect of exercise on adipokines in normal weight (NWG), overweight (OVG) and obese (OBG) groups.Plasma and serum was separated immediately after blood collection before (T0), after 6 months (T6) and 12 months (T12) of the exercise training program. The plasma or serum concentrations of leptin, adiponectin, IL-6 and resistin were determined using an Enzyme-linked immunosorbent assay (ELISA) method. The values presented are the mean ± standard error of mean. a comparison to normal weight group; b comparison to overweight group; c comparison to before program training (T0); d comparison to after 6 months of program training.
Mentions: Leptin and IL-6 levels were significantly elevated in OBG before the training (Fig 2). The chronic exercise had no effect on adipokine levels in NWG; however, training decreased leptin and adiponectin levels (by approximately 34% and 15%, respectively) after 12 months and resistin by 15% after 6 and 12 months in OVG. In OBG, the exercise diminished the leptin and resistin concentration by 12–18% after 6 months, IL-6 after 6 and 12 months (by 41–53%) and adiponectin by 18% after 12 months (Fig 2).

Bottom Line: There is a complicated relationship between adipokines and low-grade inflammation in obesity and cardiovascular disease (CVD).Physical activity practices have beneficial health effects on obesity and related disorders such as hypertension and dyslipidemia.Leptin, IL-6 levels and systolic blood pressure were significantly elevated in OBG before the training.

View Article: PubMed Central - PubMed

Affiliation: Institute of Physical Activity and Sports Sciences, Post-Graduate Program in Human Movement Science, Cruzeiro do Sul University, São Paulo, SP, Brazil.

ABSTRACT
Obesity is a worldwide epidemic that increases the risk of several well-known co-morbidities. There is a complicated relationship between adipokines and low-grade inflammation in obesity and cardiovascular disease (CVD). Physical activity practices have beneficial health effects on obesity and related disorders such as hypertension and dyslipidemia. We investigated the effects of 6 and 12 months of moderate physical training on the levels of adipokines and CVD markers in normal weight, overweight and obese volunteers. The 143 participants were followed up at baseline and after six and twelfth months of moderate regular exercise, 2 times a week, for 12 months. The volunteers were distributed into 3 groups: Normal Weight Group (NWG,), Overweight Group (OVG) and Obese Group (OBG). We evaluated blood pressure, resting heart rate, anthropometric parameters, body composition, fitness capacity (VO2max and isometric back strength), cardiovascular markers (CRP, total cholesterol, LDL-c, HDL-c, homocysteine) and adipokine levels (leptin, adiponectin, resistin, IL-6 and TNF-alpha). There were no significant changes in anthropometric parameters and body composition in any of the groups following 6 and 12 months of exercise training. Leptin, IL-6 levels and systolic blood pressure were significantly elevated in OBG before the training. Regular exercise decreased HDL-c, leptin, adiponectin and resistin levels and diastolic blood pressure in OVG. In OBG, exercise diminished HDL-c, homocysteine, leptin, resistin, IL-6, adiponectin. Moderate exercise had no effect on the body composition; however, exercise did promote beneficial effects on the low-grade inflammatory state and CVD clinical markers in overweight and obese individuals.

No MeSH data available.


Related in: MedlinePlus