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Ozurdex for the Treatment of a Patient with Birdshot Chorioretinopathy.

Moisseiev E, Moshiri A - Case Rep Ophthalmol (2015)

Bottom Line: We report a 57-year-old patient with birdshot chorioretinopathy (BCR) who was treated with bilateral Ozurdex injections.A concise review of the literature on the use of intravitreal steroids for this disease is provided.This case serves to report the clinical usefulness of Ozurdex in treating posterior vitritis associated with BCR even in the absence of macular edema.

View Article: PubMed Central - PubMed

Affiliation: UC Davis Eye Center, University of California Davis, Sacramento, Calif., USA.

ABSTRACT
We report a 57-year-old patient with birdshot chorioretinopathy (BCR) who was treated with bilateral Ozurdex injections. The patient's vitritis resolved, and visual acuity improved following this treatment. This is only the second case report focused on the treatment of BCR with Ozurdex and the first to report its use for treating vitritis. A concise review of the literature on the use of intravitreal steroids for this disease is provided. This case serves to report the clinical usefulness of Ozurdex in treating posterior vitritis associated with BCR even in the absence of macular edema.

No MeSH data available.


Related in: MedlinePlus

Ocular findings at presentation. Images of the right eye are shown. The findings were symmetric bilaterally. a Fundus photo notable for disc hyperemia and fine hypopigmented lesions in the posterior pole. The image is blurred by the vitritis. b Fluorescein angiography demonstrating hypofluorescent dots in the posterior pole. c Indocyanine green angiography demonstrating multiple hypofluorescent dots in the posterior pole. d Optical coherence tomography demonstrating normal foveal contour and outer retinal architecture, and no fluid. e Multifocal electroretinogram showing moderately reduced cone-mediated function of the posterior pole.
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Figure 1: Ocular findings at presentation. Images of the right eye are shown. The findings were symmetric bilaterally. a Fundus photo notable for disc hyperemia and fine hypopigmented lesions in the posterior pole. The image is blurred by the vitritis. b Fluorescein angiography demonstrating hypofluorescent dots in the posterior pole. c Indocyanine green angiography demonstrating multiple hypofluorescent dots in the posterior pole. d Optical coherence tomography demonstrating normal foveal contour and outer retinal architecture, and no fluid. e Multifocal electroretinogram showing moderately reduced cone-mediated function of the posterior pole.

Mentions: On examination, visual acuity was 20/30 in both eyes. Pupils were normal with no relative afferent pupillary defect, and intraocular pressures were normal. Anterior segments were normal, with very mild nuclear sclerotic cataracts OU. Dilated fundus examination revealed +2 vitreous cells and vitreal haze in both eyes, as well as optic disc hyperemia and numerous subtle round hypopigmented spots at the level of the choroid in the posterior poles (fig. 1a). Multiple hypofluorescent spots around the optic discs and along the arcades were demonstrated by fluorescein angiography (fig. 1b) and were even more pronounced by indocyanine green angiography (fig. 1c). Optical coherence tomography demonstrated a normal foveal contour with intact outer retinal architecture with no macular edema (fig. 1d). Multifocal electroretinography revealed moderately reduced cone-mediated function of the posterior poles (fig. 1e). Additional workup included normal complete blood count and chemistry tests, negative antinuclear antibody test, normal c- and p-ANCA levels, negative VDRL, normal angiotensin converting enzyme levels, nonreactive tuberculin skin test and a normal chest CT. HLA-A29 was positive.


Ozurdex for the Treatment of a Patient with Birdshot Chorioretinopathy.

Moisseiev E, Moshiri A - Case Rep Ophthalmol (2015)

Ocular findings at presentation. Images of the right eye are shown. The findings were symmetric bilaterally. a Fundus photo notable for disc hyperemia and fine hypopigmented lesions in the posterior pole. The image is blurred by the vitritis. b Fluorescein angiography demonstrating hypofluorescent dots in the posterior pole. c Indocyanine green angiography demonstrating multiple hypofluorescent dots in the posterior pole. d Optical coherence tomography demonstrating normal foveal contour and outer retinal architecture, and no fluid. e Multifocal electroretinogram showing moderately reduced cone-mediated function of the posterior pole.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608635&req=5

Figure 1: Ocular findings at presentation. Images of the right eye are shown. The findings were symmetric bilaterally. a Fundus photo notable for disc hyperemia and fine hypopigmented lesions in the posterior pole. The image is blurred by the vitritis. b Fluorescein angiography demonstrating hypofluorescent dots in the posterior pole. c Indocyanine green angiography demonstrating multiple hypofluorescent dots in the posterior pole. d Optical coherence tomography demonstrating normal foveal contour and outer retinal architecture, and no fluid. e Multifocal electroretinogram showing moderately reduced cone-mediated function of the posterior pole.
Mentions: On examination, visual acuity was 20/30 in both eyes. Pupils were normal with no relative afferent pupillary defect, and intraocular pressures were normal. Anterior segments were normal, with very mild nuclear sclerotic cataracts OU. Dilated fundus examination revealed +2 vitreous cells and vitreal haze in both eyes, as well as optic disc hyperemia and numerous subtle round hypopigmented spots at the level of the choroid in the posterior poles (fig. 1a). Multiple hypofluorescent spots around the optic discs and along the arcades were demonstrated by fluorescein angiography (fig. 1b) and were even more pronounced by indocyanine green angiography (fig. 1c). Optical coherence tomography demonstrated a normal foveal contour with intact outer retinal architecture with no macular edema (fig. 1d). Multifocal electroretinography revealed moderately reduced cone-mediated function of the posterior poles (fig. 1e). Additional workup included normal complete blood count and chemistry tests, negative antinuclear antibody test, normal c- and p-ANCA levels, negative VDRL, normal angiotensin converting enzyme levels, nonreactive tuberculin skin test and a normal chest CT. HLA-A29 was positive.

Bottom Line: We report a 57-year-old patient with birdshot chorioretinopathy (BCR) who was treated with bilateral Ozurdex injections.A concise review of the literature on the use of intravitreal steroids for this disease is provided.This case serves to report the clinical usefulness of Ozurdex in treating posterior vitritis associated with BCR even in the absence of macular edema.

View Article: PubMed Central - PubMed

Affiliation: UC Davis Eye Center, University of California Davis, Sacramento, Calif., USA.

ABSTRACT
We report a 57-year-old patient with birdshot chorioretinopathy (BCR) who was treated with bilateral Ozurdex injections. The patient's vitritis resolved, and visual acuity improved following this treatment. This is only the second case report focused on the treatment of BCR with Ozurdex and the first to report its use for treating vitritis. A concise review of the literature on the use of intravitreal steroids for this disease is provided. This case serves to report the clinical usefulness of Ozurdex in treating posterior vitritis associated with BCR even in the absence of macular edema.

No MeSH data available.


Related in: MedlinePlus